{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:59:03Z","timestamp":1767855543413,"version":"3.49.0"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"4","funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["AB is an NIHR Senior Investigator"],"award-info":[{"award-number":["AB is an NIHR Senior Investigator"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["CDF-2014-07 019"],"award-info":[{"award-number":["CDF-2014-07 019"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000362","name":"Asthma UK","doi-asserted-by":"publisher","award":["AUK-IG-2014-287"],"award-info":[{"award-number":["AUK-IG-2014-287"]}],"id":[{"id":"10.13039\/501100000362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,5,24]]},"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Lung function testing in pre-school children in the clinical setting is challenging. Most cannot perform spirometry and many infant lung function tests require sedation. Lung clearance index (LCI) derived from the multiple-breath washout (MBW) test has been shown to be sensitive to early disease changes but may be time consuming and so a shortened test (LCI<jats:sub>0.5<\/jats:sub>) may be more feasible in young children. We sought to establish feasibility of MBW in unsedated pre-school children in a clinic setting and hypothesised use of LCI<jats:sub>0.5<\/jats:sub>would increase success rates.<\/jats:p><jats:p>116 pre-school children (28 healthy controls and 88 with respiratory disease), median age 4.0\u2005years (range 2\u20136\u2005years), underwent MBW tests unsedated in a clinic setting, using sulfur hexafluoride as a tracer gas and an adapted photoacoustic gas analyser.<\/jats:p><jats:p>81 (70%) out of 116 children completed LCI and 72% completed LCI<jats:sub>0.5<\/jats:sub>measurement. Test success increased significantly in patients over 3\u2005years (0% at &lt;2.5\u2005years, 33% at 2.5\u20133\u2005years and 70% at &gt;3\u2005years, p&lt;0.0001). LCI was elevated in those with respiratory disease compared with healthy controls.<\/jats:p><jats:p>MBW is feasible in a clinic setting in unsedated pre-schoolers, particularly in those &gt;3\u2005years old, and LCI is raised in those with respiratory disease. Use of LCI<jats:sub>0.5<\/jats:sub>did not increase success rate in pre-schoolers.<\/jats:p>","DOI":"10.1183\/13993003.00374-2016","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T02:48:47Z","timestamp":1467946127000},"page":"1074-1080","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Feasibility of lung clearance index in a clinical setting in pre-school children"],"prefix":"10.1183","volume":"48","author":[{"given":"Barrett","family":"Downing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Irving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Bingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Bush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sejal","family":"Saglani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"2024102100070127000_48.4.1074.1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202345"},{"key":"2024102100070127000_48.4.1074.2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23303"},{"key":"2024102100070127000_48.4.1074.3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00791-2015"},{"key":"2024102100070127000_48.4.1074.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.01.025"},{"key":"2024102100070127000_48.4.1074.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069712"},{"key":"2024102100070127000_48.4.1074.6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00164910"},{"key":"2024102100070127000_48.4.1074.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-895OC"},{"key":"2024102100070127000_48.4.1074.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.06.010"},{"key":"2024102100070127000_48.4.1074.9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.077784"},{"key":"2024102100070127000_48.4.1074.10","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.022590"},{"key":"2024102100070127000_48.4.1074.11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200911-1646OC"},{"key":"2024102100070127000_48.4.1074.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00076012"},{"key":"2024102100070127000_48.4.1074.13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.096958"},{"key":"2024102100070127000_48.4.1074.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70344-0"},{"key":"2024102100070127000_48.4.1074.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.005"},{"key":"2024102100070127000_48.4.1074.16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.071134"},{"key":"2024102100070127000_48.4.1074.17","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.082628"},{"key":"2024102100070127000_48.4.1074.18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201304-0800OC"},{"key":"2024102100070127000_48.4.1074.19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098487"},{"key":"2024102100070127000_48.4.1074.20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002108"},{"key":"2024102100070127000_48.4.1074.21","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00042-2015"},{"key":"2024102100070127000_48.4.1074.22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00005512"},{"key":"2024102100070127000_48.4.1074.23","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21093"},{"key":"2024102100070127000_48.4.1074.24","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.125831"},{"key":"2024102100070127000_48.4.1074.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2005.09.009"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00374-2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:35:23Z","timestamp":1740378923000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00374-2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,9,30]]},"published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1183\/13993003.00374-2016"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00374-2016","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]}}}