{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:38:17Z","timestamp":1785289097467,"version":"3.55.0"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"5","funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["LIFECYCLE project, grant agreement no 733206; 2016"],"award-info":[{"award-number":["LIFECYCLE project, grant agreement no 733206; 2016"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERA HDHL","award":["ALPHABET project no 696295; 2017"],"award-info":[{"award-number":["ALPHABET project no 696295; 2017"]}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["VIDI"],"award-info":[{"award-number":["VIDI"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["no 529051014; 2017"],"award-info":[{"award-number":["no 529051014; 2017"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,9,29]]},"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Pre-eclampsia is associated with an increased risk of bronchopulmonary dysplasia, wheezing and asthma in later childhood. Currently, there are no studies available investigating maternal blood pressure measurements during multiple time-points in pregnancy and respiratory outcome measures in the child.<\/jats:p><jats:p>We examined the associations of maternal blood pressure and hypertensive disorders with the risk of lower lung function, wheezing and asthma in children aged 10\u2005years. This study among 4894 children was embedded in a population-based prospective cohort study. We used multivariate analyses, taking lifestyle and socioeconomic factors into account.<\/jats:p><jats:p>We observed consistent associations per 5\u2005mmHg higher maternal blood pressure in early pregnancy with a lower forced expiratory volume in 1\u2005s\/forced vital capacity ratio (z-score \u22120.03 (95% CI \u22120.05\u2013\u200a\u22120.01)) and per 5\u2005mmHg higher blood pressure in late pregnancy with a higher risk for current wheezing and current asthma (OR 1.07 (95% CI 1.02\u20131.12) and 1.06 (95% CI 1.00\u20131.11), respectively). We found no associations of maternal hypertensive disorders during pregnancy with child lung function, current wheezing or current asthma.<\/jats:p><jats:p>Our results suggest that higher blood pressure in pregnant women is associated with lower lung function and increased risks of current wheezing and current asthma in children. The associations may be trimester specific.<\/jats:p>","DOI":"10.1183\/13993003.00378-2018","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T11:45:45Z","timestamp":1539258345000},"page":"1800378","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Maternal blood pressure and hypertensive disorders during pregnancy and childhood respiratory morbidity: the Generation R Study"],"prefix":"10.1183","volume":"52","author":[{"given":"Freke A.","family":"Wilmink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman T.","family":"den Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin 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