{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:00:00Z","timestamp":1767772800655,"version":"3.37.3"},"reference-count":32,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,5,17]]},"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Changes in airway calibre have the potential to modify exhaled nitric oxide fraction (<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>) values and could hamper how<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>captures changes in asthma control. Here, our objective was to assess whether forced expiratory volume in 1\u2005s (FEV<jats:sub>1<\/jats:sub>) variations alter the ability of<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>to reflect asthma control.<\/jats:p><jats:p><jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>, asthma control (Asthma Control Questionnaire (ACQ)) and FEV<jats:sub>1<\/jats:sub>were measured at least two times in 527 patients during 1819 pairs of visits. Determinants of<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>\u2013ACQ discordance probability were evaluated through a logistic regression analysis. The effectiveness of<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>at capturing either asthma control worsening or improvement between two visits was then assessed by undertaking a stratified receiver operating characteristic curves analysis.<\/jats:p><jats:p>When FEV<jats:sub>1<\/jats:sub>and<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>change in the same direction, the odds of<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>\u2013ACQ being discordant are multiplied by 3 (p&lt;0.001). The area under the curve values were 0.765 (95% CI 0.713\u20130.805) (improvement; p&lt;0.001) and 0.769 (95% 0.706\u20130.810) (worsening; p&lt;0.001) or 0.590 (95% 0.531\u20130.653) (improvement; p=0.001) and 0.498 (95% 0.416\u20130.567) (worsening; p=0.482) when FEV<jats:sub>1<\/jats:sub>and<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>changed in the opposite or same direction, respectively.<\/jats:p><jats:p>The manner in which<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>and FEV<jats:sub>1<\/jats:sub>vary concomitantly when asthma control changes determines the ability of<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>to capture this change: parallel or opposite changes in FEV<jats:sub>1<\/jats:sub>and<jats:italic>F<\/jats:italic><jats:sub>ENO<\/jats:sub>either decrease or increase this ability to capture asthma control changes.<\/jats:p>","DOI":"10.1183\/13993003.00392-2017","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T09:32:55Z","timestamp":1505727175000},"page":"1700392","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Airway calibre variation is a major determinant of exhaled nitric oxide's ability to capture asthma control"],"prefix":"10.1183","volume":"50","author":[{"given":"Alain","family":"Michils","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaryllis","family":"Haccuria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Michiels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Van Muylem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"2024101904195766000_50.2.1700392.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02314.x"},{"key":"2024101904195766000_50.2.1700392.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"2024101904195766000_50.2.1700392.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"2024101904195766000_50.2.1700392.4","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2017. http:\/\/ginasthma.org\/2017-gina-report-global-strategy-for-asthma-management-and-prevention Date last accessed: February 28, 2017."},{"key":"2024101904195766000_50.2.1700392.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00285302"},{"key":"2024101904195766000_50.2.1700392.6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9809100"},{"key":"2024101904195766000_50.2.1700392.7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.2.9912091"},{"key":"2024101904195766000_50.2.1700392.8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00020407"},{"key":"2024101904195766000_50.2.1700392.9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/ajrccm.158.1.9703005","article-title":"Exhaled nitric oxide (NO) is reduced shortly after bronchoconstriction to direct and indirect stimuli in asthma","volume":"158","author":"de Gouw","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101904195766000_50.2.1700392.10","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.01506.x"},{"key":"2024101904195766000_50.2.1700392.11","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.9.771"},{"key":"2024101904195766000_50.2.1700392.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1070"},{"key":"2024101904195766000_50.2.1700392.13","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01019.2007"},{"key":"2024101904195766000_50.2.1700392.14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fphys.2016.00255","article-title":"Modeling of the nitric oxide transport in the human lungs","volume":"7","author":"Karamaoun","year":"2016","journal-title":"Front Physiol"},{"key":"2024101904195766000_50.2.1700392.15","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91614.2008"},{"key":"2024101904195766000_50.2.1700392.16","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jaci.2015.09.054","article-title":"Different patterns of exhaled nitric oxide response to","volume":"137","author":"Michils","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2024101904195766000_50.2.1700392.17","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7543345"},{"key":"2024101904195766000_50.2.1700392.18","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"2024101904195766000_50.2.1700392.19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00154008"},{"key":"2024101904195766000_50.2.1700392.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.10.008"},{"key":"2024101904195766000_50.2.1700392.21","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d29.x"},{"key":"2024101904195766000_50.2.1700392.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.08.012"},{"key":"2024101904195766000_50.2.1700392.23","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"2024101904195766000_50.2.1700392.24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-060ST"},{"key":"2024101904195766000_50.2.1700392.25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2500\/aap.2008.29.3098","article-title":"Exhaled nitric oxide levels during treatment in patients hospitalized with asthma","volume":"29","author":"Baptist","year":"2008","journal-title":"Allergy Asthma Proc"},{"key":"2024101904195766000_50.2.1700392.26","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2500\/aap.2012.33.3613","article-title":"Emergency department treatment of adults with acute asthma exacerbations: effect on exhaled nitric oxide levels","volume":"33","author":"Silverberg","year":"2012","journal-title":"Allergy Asthma Proc"},{"key":"2024101904195766000_50.2.1700392.27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1081-1206(10)60140-8","article-title":"Time-dependent effects of inhaled corticosteroids on lung function, bronchial hyperresponsiveness, and airway inflammation in asthma","volume":"103","author":"Mehta","year":"2009","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2024101904195766000_50.2.1700392.28","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1427OC"},{"key":"2024101904195766000_50.2.1700392.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61448-8"},{"key":"2024101904195766000_50.2.1700392.30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043596"},{"key":"2024101904195766000_50.2.1700392.31","first-page":"CD011440","article-title":"Exhaled nitric oxide levels to guide treatment for adults with asthma","volume":"9","author":"Petsky","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2024101904195766000_50.2.1700392.32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03226.x"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00392-2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:43:18Z","timestamp":1740379398000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00392-2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,8,17]]},"published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1183\/13993003.00392-2017"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00392-2017","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"type":"print","value":"0903-1936"},{"type":"electronic","value":"1399-3003"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}