{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:48:58Z","timestamp":1790840938457,"version":"4.1.0"},"reference-count":57,"publisher":"European Respiratory Society (ERS)","issue":"1","funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,10,23]]},"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Acute exacerbations and worsening of idiopathic pulmonary fibrosis (IPF) have been associated with exposure to ozone (O\n                    <jats:sub>3<\/jats:sub>\n                    ), nitrogen dioxide (NO\n                    <jats:sub>2<\/jats:sub>\n                    ) and particulate matter, but chronic exposure to air pollution might also affect the incidence of IPF. We investigated the association between chronic exposure to NO\n                    <jats:sub>2<\/jats:sub>\n                    , O\n                    <jats:sub>3<\/jats:sub>\n                    and particulate matter with an aerodynamic diameter &lt;10\u2005\u03bcm (PM\n                    <jats:sub>10<\/jats:sub>\n                    ) and IPF incidence in Northern Italy between 2005 and 2010.\n                  <\/jats:p>\n                  <jats:p>\n                    Daily predictions of PM\n                    <jats:sub>10<\/jats:sub>\n                    concentrations were obtained from spatiotemporal models, and NO\n                    <jats:sub>2<\/jats:sub>\n                    and O\n                    <jats:sub>3<\/jats:sub>\n                    hourly concentrations from fixed monitoring stations. We identified areas with homogenous exposure to each pollutant. We built negative binomial models to assess the association between area-specific IPF incidence rate, estimated through administrative databases, and average overall and seasonal PM\n                    <jats:sub>10<\/jats:sub>\n                    , NO\n                    <jats:sub>2<\/jats:sub>\n                    , and 8-hour maximum O\n                    <jats:sub>3<\/jats:sub>\n                    concentrations.\n                  <\/jats:p>\n                  <jats:p>\n                    Using unadjusted models, an increment of 10\u2005\u00b5g\u00b7m\n                    <jats:sup>\u22123<\/jats:sup>\n                    in NO\n                    <jats:sub>2<\/jats:sub>\n                    concentration was associated with an increase between 7.93% (95% CI 0.36\u201316.08%) and 8.41% (95% CI \u22120.23\u201317.80%) in IPF incidence rate, depending on the season. After adjustment for potential confounders, estimated effects were similar in magnitude, but with larger confidence intervals.\n                  <\/jats:p>\n                  <jats:p>Although confirmatory studies are needed, our results trace a potential association between exposure to traffic pollution and the development of IPF.<\/jats:p>","DOI":"10.1183\/13993003.00397-2017","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T20:10:16Z","timestamp":1516911016000},"page":"1700397","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":137,"title":["The association between air pollution and the incidence of idiopathic pulmonary fibrosis in Northern Italy"],"prefix":"10.1183","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-3740","authenticated-orcid":false,"given":"Sara","family":"Conti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Harari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Caminati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Zanobetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel\u00a0D.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro A.","family":"Bertazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Cesana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Madotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"2024101909231312000_51.1.1700397.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.03.012"},{"key":"2024101909231312000_51.1.1700397.2","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00003214"},{"key":"2024101909231312000_51.1.1700397.3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/resp.12576","article-title":"Smoking-related idiopathic interstitial pneumonia: a review","volume":"21","author":"Margaritopoulos","year":"2016","journal-title":"Respirology"},{"key":"2024101909231312000_51.1.1700397.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"2024101909231312000_51.1.1700397.5","doi-asserted-by":"publisher","DOI":"10.1179\/oeh.2008.14.2.117"},{"key":"2024101909231312000_51.1.1700397.6","first-page":"193","article-title":"Asbestosis and environmental causes of usual interstitial pneumonia","volume":"21","author":"Gulati","year":"2015","journal-title":"Curr Opin Pulm Med"},{"key":"2024101909231312000_51.1.1700397.7","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.4.307"},{"key":"2024101909231312000_51.1.1700397.8","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00000713"},{"key":"2024101909231312000_51.1.1700397.9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1101277"},{"key":"2024101909231312000_51.1.1700397.10","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1055\/s-2006-957329","article-title":"Host-environment interactions in pulmonary fibrosis","volume":"27","author":"Garantziotis","year":"2006","journal-title":"Semin Respir Crit Care Med"},{"key":"2024101909231312000_51.1.1700397.11","doi-asserted-by":"publisher","DOI":"10.2217\/epi.12.10"},{"key":"2024101909231312000_51.1.1700397.12","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12016-013-8398-3","article-title":"Epigenetics in immune-mediated pulmonary diseases","volume":"45","author":"Liu","year":"2013","journal-title":"Clin Rev Allergy Immunol"},{"key":"2024101909231312000_51.1.1700397.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00122213"},{"key":"2024101909231312000_51.1.1700397.14","doi-asserted-by":"crossref","unstructured":"Ses\u00e9 L , Nunes H , Cottin V , et\u00a0al. 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