{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:06:59Z","timestamp":1773796019203,"version":"3.50.1"},"reference-count":21,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN26820118C"],"award-info":[{"award-number":["HHSN26820118C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24 HL111316"],"award-info":[{"award-number":["K24 HL111316"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL00749-21"],"award-info":[{"award-number":["T32 HL00749-21"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,5,10]]},"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>High-resolution computed tomography (HRCT) may be useful for diagnosing hypersensitivity pneumonitis. Here, we develop and validate a radiological diagnosis model and model-based points score.<\/jats:p><jats:p>Patients with interstitial lung disease seen at the University of Michigan Health System (derivation cohort) or enrolling in the Lung Tissue Research Consortium (validation cohort) were included. A thin-section, inspiratory HRCT scan was required. Thoracic radiologists documented radiological features.<\/jats:p><jats:p>The derivation cohort comprised 356 subjects (33.9% hypersensitivity pneumonitis) and the validation cohort comprised 424 subjects (15.5% hypersensitivity pneumonitis). An age-, sex- and smoking status-adjusted logistic regression model identified extent of mosaic attenuation or air trapping greater than that of reticulation (\u201cMA-AT&gt;Reticulation\u201d; OR 6.20, 95% CI 3.53\u201310.90; p&lt;0.0001) and diffuse axial disease distribution (OR 2.33, 95% CI 1.31\u20134.16; p=0.004) as hypersensitivity pneumonitis predictors (area under the receiver operating characteristic curve 0.814). A model-based score &gt;2 (1 point for axial distribution, 2 points for \u201cMA-AT&gt;Reticulation\u201d) has specificity 90% and positive predictive value (PPV) 74% in the derivation cohort and specificity 96% and PPV 44% in the validation cohort. Similar model performance is seen with population restriction to those reporting no exposure (score &gt;2: specificity 91%).<\/jats:p><jats:p>When radiological mosaic attenuation or air trapping are more extensive than reticulation and disease has diffuse axial distribution, hypersensitivity pneumonitis specificity is high and false diagnosis risk low (&lt;10%), but PPV is diminished in a low-prevalence setting.<\/jats:p>","DOI":"10.1183\/13993003.00443-2018","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T04:25:11Z","timestamp":1529987111000},"page":"1800443","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":64,"title":["Development and validation of a radiological diagnosis model for hypersensitivity pneumonitis"],"prefix":"10.1183","volume":"52","author":[{"given":"Margaret 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