{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:24:19Z","timestamp":1787163859154,"version":"build-2736575974"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"name":"The David Hide Asthma and Allergy Research Trust"},{"DOI":"10.13039\/501100000362","name":"Asthma UK","doi-asserted-by":"publisher","award":["364"],"award-info":[{"award-number":["364"]}],"id":[{"id":"10.13039\/501100000362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL082925"],"award-info":[{"award-number":["R01 HL082925"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2019,11,22]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>We investigated associations of asthma and smoking with lung function and airway reversibility from childhood to early adulthood.<\/jats:p>\n                  <jats:p>The population-based Isle of Wight Birth Cohort (n=1456) was assessed at birth, and at 1, 2, 4, 10, 18 and 26\u2005years. Asthma was defined as physician diagnosis plus current wheeze and\/or treatment. Spirometry was conducted at 10 (n=981), 18 (n=839) and 26\u2005years (n=547). Individuals were subdivided into nonsmokers without asthma, nonsmokers with asthma, smokers without asthma and smokers with asthma, based on asthma and smoking status at 26 years. Their lung function trajectories from 10 to 26\u2005years were examined using longitudinal models.<\/jats:p>\n                  <jats:p>\n                    Nonsmokers with asthma had smaller forced expiratory volume in 1\u2005s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ), FEF\n                    <jats:sub>25\u201375%<\/jats:sub>\n                    (forced expiratory flow at 25\u201375% of forced vital capacity (FVC)) and FEV\n                    <jats:sub>1<\/jats:sub>\n                    \/FVC ratio compared to nonsmokers without asthma at age 10 and 18\u2005years, with differences reduced after bronchodilator (pre-bronchodilator FEV\n                    <jats:sub>1<\/jats:sub>\n                    at 26\u2005years 3.75\u2005L\n                    <jats:italic>versus<\/jats:italic>\n                    4.02\u2005L, p&lt;0.001; post-bronchodilator 4.02\u2005L\n                    <jats:italic>versus<\/jats:italic>\n                    4.16\u2005L, p=0.08). This lung function deficit did not worsen after 18\u2005years. Smokers without asthma had smaller FEF\n                    <jats:sub>25\u201375%<\/jats:sub>\n                    and FEV\n                    <jats:sub>1<\/jats:sub>\n                    \/FVC ratio (but not FEV\n                    <jats:sub>1<\/jats:sub>\n                    ) at 26\u2005years compared to nonsmokers without asthma, with the deficit appearing after 18\u2005years and persisting despite bronchodilator response (for FEV\n                    <jats:sub>1<\/jats:sub>\n                    \/FVC ratio at 26\u2005years 0.80\n                    <jats:italic>versus<\/jats:italic>\n                    0.81, p=0.002; post-bronchodilator 0.83\n                    <jats:italic>versus<\/jats:italic>\n                    0.85, p=0.005). Smokers with asthma had worse lung function compared to other groups.\n                  <\/jats:p>\n                  <jats:p>Lung function deficits associated with asthma and smoking occur early in life. They are not fully responsive to bronchodilators, indicating a risk for long-term lung health, which highlights the need to institute preventive measures in adolescence and early adult life before irreversible damage occurs.<\/jats:p>","DOI":"10.1183\/13993003.00477-2019","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T15:05:23Z","timestamp":1576163123000},"page":"1900477","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Association of asthma and smoking with lung function impairment in adolescence and early adulthood: the Isle of Wight Birth Cohort Study"],"prefix":"10.1183","volume":"55","author":[{"given":"S. Hasan","family":"Arshad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hodgekiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-0464","authenticated-orcid":false,"given":"John W.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Kurukulaaratchy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Karmaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"2024102101180474000_55.3.1900477.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0047OC"},{"key":"2024102101180474000_55.3.1900477.2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.127.6.725"},{"key":"2024102101180474000_55.3.1900477.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022363"},{"key":"2024102101180474000_55.3.1900477.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00021707"},{"key":"2024102101180474000_55.3.1900477.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411532"},{"key":"2024102101180474000_55.3.1900477.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6077.1645"},{"key":"2024102101180474000_55.3.1900477.7","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9981-5"},{"key":"2024102101180474000_55.3.1900477.8","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203538"},{"key":"2024102101180474000_55.3.1900477.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513737"},{"key":"2024102101180474000_55.3.1900477.10","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/ije\/dyy023","article-title":"Cohort 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