{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:30:23Z","timestamp":1790641823658,"version":"4.1.0"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"3","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K25 HL130637"],"award-info":[{"award-number":["K25 HL130637"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL092870"],"award-info":[{"award-number":["P01 HL092870"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL114501"],"award-info":[{"award-number":["P01 HL114501"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL132825"],"award-info":[{"award-number":["P01 HL132825"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL0866601"],"award-info":[{"award-number":["R01 HL0866601"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL089856"],"award-info":[{"award-number":["R01 HL089856"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL097163"],"award-info":[{"award-number":["R01 HL097163"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL111024"],"award-info":[{"award-number":["R01 HL111024"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL113264"],"award-info":[{"award-number":["R01 HL113264"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL116473"],"award-info":[{"award-number":["R01 HL116473"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL118455"],"award-info":[{"award-number":["R01 HL118455"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL122464"],"award-info":[{"award-number":["R01 HL122464"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL123546"],"award-info":[{"award-number":["R01 HL123546"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL129920"],"award-info":[{"award-number":["R01 HL129920"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL130275"],"award-info":[{"award-number":["R01 HL130275"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL130974"],"award-info":[{"award-number":["R01 HL130974"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R25 ES025476"],"award-info":[{"award-number":["R25 ES025476"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R33 HL120770"],"award-info":[{"award-number":["R33 HL120770"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R33 HL120794"],"award-info":[{"award-number":["R33 HL120794"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL007633"],"award-info":[{"award-number":["T32 HL007633"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01 AI095219"],"award-info":[{"award-number":["U01 AI095219"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UH2 HL123442"],"award-info":[{"award-number":["UH2 HL123442"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Icelandic Research Fund and Landspitali Scientific Fund","award":["A-2015-030"],"award-info":[{"award-number":["A-2015-030"]}]},{"name":"Icelandic Research Fund and Landspitali Scientific Fund","award":["A-2016-023"],"award-info":[{"award-number":["A-2016-023"]}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K23 CA157631"],"award-info":[{"award-number":["K23 CA157631"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIA","award":["27120120022C"],"award-info":[{"award-number":["27120120022C"]}]},{"name":"NIA","award":["HHSN27120120022C"],"award-info":[{"award-number":["HHSN27120120022C"]}]},{"name":"NIA","award":["N01-AG-1-2100"],"award-info":[{"award-number":["N01-AG-1-2100"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,5,31]]},"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>The<jats:italic>MUC5B<\/jats:italic>promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We evaluated the associations between the<jats:italic>MUC5B<\/jats:italic>genotype and ILA in cohorts with extensive imaging characterisation.<\/jats:p><jats:p>We performed ILA phenotyping and<jats:italic>MUC5B<\/jats:italic>promoter genotyping in 5308 and 9292 participants from the AGES-Reykjavik and COPDGene cohorts, respectively.<\/jats:p><jats:p>We found that ILA was present in 7% of participants from the AGES-Reykjavik, 8% of non-Hispanic white participants from COPDGene and 7% of African-American participants from COPDGene. Although the<jats:italic>MUC5B<\/jats:italic>genotype was strongly associated (after correction for multiple testing) with ILA (OR 2.1, 95% CI 1.8\u20132.4, p=1\u00d710<jats:sup>\u221226<\/jats:sup>), there was evidence of significant heterogeneity between cohorts (I<jats:sup>2<\/jats:sup>=81%). When narrowed to specific radiologic subtypes, (<jats:italic>e.g.<\/jats:italic>subpleural ILA), the<jats:italic>MUC5B<\/jats:italic>genotype remained strongly associated (OR 2.6, 95% CI 2.2\u20133.1, p=1\u00d710<jats:sup>\u221230<\/jats:sup>) with minimal heterogeneity (I<jats:sup>2<\/jats:sup>=0%). Although there was no evidence that the<jats:italic>MUC5B<\/jats:italic>genotype influenced survival, there was evidence that<jats:italic>MUC5B<\/jats:italic>genotype improved risk prediction for possible usual interstitial pneumonia (UIP) or a UIP pattern in non-Hispanic white populations.<\/jats:p><jats:p>The<jats:italic>MUC5B<\/jats:italic>promoter polymorphism is strongly associated with ILA and specific radiologic subtypes of ILA, with varying degrees of heterogeneity in the underlying populations.<\/jats:p>","DOI":"10.1183\/13993003.00537-2017","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:10:59Z","timestamp":1505175059000},"page":"1700537","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":76,"title":["The<i>MUC5B<\/i>promoter polymorphism is associated with specific interstitial lung abnormality subtypes"],"prefix":"10.1183","volume":"50","author":[{"given":"Rachel K.","family":"Putman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gudmundsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurdur","family":"Sigurdsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edas F.","family":"Gudmundsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudny","family":"Eir\u00edksdott\u00edr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-5433","authenticated-orcid":false,"given":"Thor","family":"Aspelund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"San Jos\u00e9 Est\u00e9par","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitake","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yanagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souheil","family":"El-Chemaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Raby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan O.","family":"Rosas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Washko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin K.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Hatabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Hunninghake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"2024101904233711000_50.3.1700537.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007285"},{"key":"2024101904233711000_50.3.1700537.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1216076"},{"key":"2024101904233711000_50.3.1700537.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1966OC"},{"key":"2024101904233711000_50.3.1700537.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.05.014"},{"key":"2024101904233711000_50.3.1700537.5","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1164\/rccm.201512-2523OC","article-title":"Development and progression of interstitial lung abnormalities in the Framingham Heart Study","volume":"194","author":"Araki","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101904233711000_50.3.1700537.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201109-1618OC"},{"key":"2024101904233711000_50.3.1700537.7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0518"},{"key":"2024101904233711000_50.3.1700537.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013660"},{"key":"2024101904233711000_50.3.1700537.9","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk115"},{"key":"2024101904233711000_50.3.1700537.10","doi-asserted-by":"publisher","DOI":"10.3109\/15412550903499522"},{"key":"2024101904233711000_50.3.1700537.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2009.07.016"},{"key":"2024101904233711000_50.3.1700537.12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"2024101904233711000_50.3.1700537.13","first-page":"690","article-title":"Lung extraction, lobe segmentation and hierarchical region assessment for quantitative analysis on high resolution computed tomography images","volume":"12","author":"Ross","year":"2009","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"2024101904233711000_50.3.1700537.14","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"2024101904233711000_50.3.1700537.15","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70045-6"},{"key":"2024101904233711000_50.3.1700537.16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2219PP"},{"key":"2024101904233711000_50.3.1700537.17","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2609"},{"key":"2024101904233711000_50.3.1700537.18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201109-1618OC"},{"key":"2024101904233711000_50.3.1700537.19","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00129-2016"},{"key":"2024101904233711000_50.3.1700537.20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1164\/rccm.201509-1753OC","article-title":"Galectin-3 is associated with restrictive lung disease and interstitial lung abnormalities","volume":"194","author":"Ho","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101904233711000_50.3.1700537.21","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201509-1872LE"},{"key":"2024101904233711000_50.3.1700537.22","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201406-1162OC"},{"key":"2024101904233711000_50.3.1700537.23","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202943"},{"key":"2024101904233711000_50.3.1700537.24","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.chest.2015.11.009","article-title":"CT imaging phenotypes of pulmonary fibrosis in the MUC5B promoter site polymorphism","volume":"149","author":"Chung","year":"2016","journal-title":"Chest"},{"key":"2024101904233711000_50.3.1700537.25","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.8.494"},{"key":"2024101904233711000_50.3.1700537.26","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.20.2507"},{"key":"2024101904233711000_50.3.1700537.27","unstructured":"Online Mendelian Inheritance in Man. Mucin 5 sB, tracheobronchial: MUC5B. OMIM no. 600770. http:\/\/useastensemblorg\/Homo_sapiens\/Variation\/Population?db=core;r=11:1219491-1220491;v=rs35705950;vdb=variation;vf=10314659 Date last accessed: April 30, 2017. Date last updated: February 4, 2014."},{"key":"2024101904233711000_50.3.1700537.28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907727"},{"key":"2024101904233711000_50.3.1700537.29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706728"},{"key":"2024101904233711000_50.3.1700537.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028931"},{"key":"2024101904233711000_50.3.1700537.31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5827"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00537-2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:43:46Z","timestamp":1740379426000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00537-2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9,11]]},"published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1183\/13993003.00537-2017"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00537-2017","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}