{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:37:35Z","timestamp":1792787855164,"version":"4.5.0"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"name":"Netherlands Lung Foundation","award":["3.2.06.031"],"award-info":[{"award-number":["3.2.06.031"]}]},{"name":"Netherlands Lung Foundation","award":["3.2.07.012"],"award-info":[{"award-number":["3.2.07.012"]}]},{"name":"Netherlands Lung Foundation","award":["3.2.10.069"],"award-info":[{"award-number":["3.2.10.069"]}]},{"name":"Netherlands Lung Foundation","award":["5.2.13.064JO"],"award-info":[{"award-number":["5.2.13.064JO"]}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["CRT 114696"],"award-info":[{"award-number":["CRT 114696"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["90713477"],"award-info":[{"award-number":["90713477"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2019,5,10]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>\n                    Neutrophilic inflammation in asthma is associated with interleukin (IL)-17A, corticosteroid-insensitivity and bronchodilator-induced forced expiratory volume in 1\u2005s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ) reversibility. IL-17A synergises with tumour necrosis factor (TNF)-\u03b1 in the production of the neutrophil chemokine CXCL-8 by primary bronchial epithelial cells (PBECs).\n                  <\/jats:p>\n                  <jats:p>We hypothesised that local neutrophilic inflammation in asthma correlates with IL-17A and TNF-\u03b1-induced CXCL-8 production by PBECs from asthma patients.<\/jats:p>\n                  <jats:p>\n                    PBECs from most asthma patients displayed an exaggerated CXCL-8 production in response to TNF-\u03b1 and IL-17A, but not to TNF-\u03b1 alone, and which was also insensitive to corticosteroids. This hyperresponsiveness of PBECs strongly correlated with CXCL-8 levels and neutrophil numbers in bronchoalveolar lavage from the corresponding patients, but not with that of eosinophils. In addition, this hyperresponsiveness also correlated with bronchodilator-induced FEV\n                    <jats:sub>1<\/jats:sub>\n                    % reversibility. At the molecular level, epithelial hyperresponsiveness was associated with failure of the translational repressor T-cell internal antigen-1 related protein (TiAR) to translocate to the cytoplasm to halt CXCL-8 production, as confirmed by TiAR knockdown. This is in line with the finding that hyperresponsive PBECs also produced enhanced levels of other inflammatory mediators.\n                  <\/jats:p>\n                  <jats:p>\n                    Hyperresponsive PBECs in asthma patients may underlie neutrophilic and corticosteroid-insensitive inflammation and a reduced FEV\n                    <jats:sub>1<\/jats:sub>\n                    , irrespective of eosinophilic inflammation. Normalising cytoplasmic translocation of TiAR is a potential therapeutic target in neutrophilic, corticosteroid-insensitive asthma.\n                  <\/jats:p>","DOI":"10.1183\/13993003.00547-2019","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:25:22Z","timestamp":1558398322000},"page":"1900547","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Neutrophilic inflammation in asthma and defective epithelial translational control"],"prefix":"10.1183","volume":"54","author":[{"given":"Abilash","family":"Ravi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saheli","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemiek","family":"Dijkhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter I.","family":"Bonta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Sterk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Lutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"2024102100590282000_54.2.1900547.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1754OC"},{"key":"2024102100590282000_54.2.1900547.2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2678"},{"key":"2024102100590282000_54.2.1900547.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403290"},{"key":"2024102100590282000_54.2.1900547.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403291"},{"key":"2024102100590282000_54.2.1900547.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1414OC"},{"key":"2024102100590282000_54.2.1900547.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707413104"},{"key":"2024102100590282000_54.2.1900547.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.012"},{"key":"2024102100590282000_54.2.1900547.8","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2684"},{"key":"2024102100590282000_54.2.1900547.9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.4089"},{"key":"2024102100590282000_54.2.1900547.10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101376"},{"key":"2024102100590282000_54.2.1900547.11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.intimp.2013.10.004","article-title":"Th17 response to Dermatophagoides pteronyssinus is related to late-phase airway and systemic inflammation in allergic asthma","volume":"17","author":"Bajoriuniene","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"2024102100590282000_54.2.1900547.12","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1926"},{"key":"2024102100590282000_54.2.1900547.13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2318OC"},{"key":"2024102100590282000_54.2.1900547.14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1047"},{"key":"2024102100590282000_54.2.1900547.15","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2737"},{"key":"2024102100590282000_54.2.1900547.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00017911"},{"key":"2024102100590282000_54.2.1900547.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.06.023"},{"key":"2024102100590282000_54.2.1900547.18","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0022OC"},{"key":"2024102100590282000_54.2.1900547.19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.4135"},{"key":"2024102100590282000_54.2.1900547.20","doi-asserted-by":"crossref","first-page":"e1003747","DOI":"10.1371\/journal.pgen.1003747","article-title":"IL-17 attenuates degradation of ARE-mRNAs by changing the cooperation between AU-binding proteins and microRNA16","volume":"9","author":"Chowdhury","year":"2013","journal-title":"PLoS Genet"},{"key":"2024102100590282000_54.2.1900547.21","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819584f9"},{"key":"2024102100590282000_54.2.1900547.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.019"},{"key":"2024102100590282000_54.2.1900547.23","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.153643"},{"key":"2024102100590282000_54.2.1900547.24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0896OC"},{"key":"2024102100590282000_54.2.1900547.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.011"},{"key":"2024102100590282000_54.2.1900547.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.038"},{"key":"2024102100590282000_54.2.1900547.27","unstructured":"\u00d6stling J , van Geest M , Schofield JPR , et\u00a0al. 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