{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:43:11Z","timestamp":1791582191191,"version":"4.3.4"},"reference-count":46,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publications.ersnet.org\/user-licence"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["Project Grant"],"award-info":[{"award-number":["Project Grant"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Tier 2 Canada Research Chair"],"award-info":[{"award-number":["Tier 2 Canada Research Chair"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2025,10,15]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Existing computed tomography (CT) vascular pruning measures rely on volumes, such as the proportion of blood volume in vessels with cross-sectional area (CSA) \u22645\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      or CSA \u226410\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      \/total blood vessel volume (BV5\/TBV or BV10\/TBV, respectively), but may underestimate vascular pruning due to blood redistribution to larger vessels in individuals with milder COPD. We aim to develop a novel CT vessel measure, the total vessel count (TVC), quantify small and combined small\/intermediate vessel count percentages, and compare these measures with BV5\/TBV and BV10\/TBV in terms of associations with lung function and its decline. As a secondary aim, associations with exercise capacity and COPD symptoms will be investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CanCOLD (Canadian Cohort Obstructive Lung Disease) participants underwent CT imaging. BV5\/TBV and BV10\/TBV were generated using vessel segmentation. TVC and small (CSA \u22645\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      , VC\n                      <jats:sub>\u22645<\/jats:sub>\n                      \/TVC) and combined small\/intermediate (CSA \u226410\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      , VC\n                      <jats:sub>\u226410<\/jats:sub>\n                      \/TVC) vessel count percentages were calculated. Fully adjusted regression models assessed associations with forced expiratory volume in 1\u2005s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ), FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide (\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>LCO<\/jats:sub>\n                      ), accelerated FEV\n                      <jats:sub>1<\/jats:sub>\n                      decline over 3\u2005years, peak oxygen uptake (\n                      <jats:italic>V\u0307<\/jats:italic>\n                      <jats:sub>\n                        O\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      <jats:sub>peak<\/jats:sub>\n                      ), 6-min walk distance (6MWD) and Medical Research Council (MRC) dyspnoea scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      1254 CanCOLD participants were investigated. TVC, VC\n                      <jats:sub>\u22645<\/jats:sub>\n                      \/TVC and VC\n                      <jats:sub>\u226410<\/jats:sub>\n                      \/TVC were associated with FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC (p&lt;0.05),\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>LCO<\/jats:sub>\n                      (p&lt;0.05) and FEV\n                      <jats:sub>1<\/jats:sub>\n                      decline (p&lt;0.05); VC\n                      <jats:sub>\u226410<\/jats:sub>\n                      \/TVC was associated with\n                      <jats:italic>V\u0307<\/jats:italic>\n                      <jats:sub>\n                        O\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      <jats:sub>peak<\/jats:sub>\n                      (p&lt;0.05), and both VC\n                      <jats:sub>\u22645<\/jats:sub>\n                      \/TVC and VC\n                      <jats:sub>\u226410<\/jats:sub>\n                      \/TVC were associated with MRC (p&lt;0.05). BV5\/TBV and BV10\/TBV were only associated with 6MWD (p&lt;0.05) and MRC (p&lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pulmonary vessel count percent, a measure of vasculature narrowing\/loss, is associated with lung function and its decline, reduced exercise capacity, and increased symptoms in COPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.00560-2025","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T05:23:43Z","timestamp":1765171423000},"page":"2500560","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Computed tomography total vessel count and vessel count percentages: associations with exercise capacity, symptoms and rapid FEV\n                    <sub>1<\/sub>\n                    decline in COPD"],"prefix":"10.1183","volume":"67","author":[{"given":"Gaurav Veer","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Asghar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie \u00c9.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-4821","authenticated-orcid":false,"given":"Daniel","family":"Genkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-038X","authenticated-orcid":false,"given":"Jean","family":"Bourbeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan C.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Stickland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-784X","authenticated-orcid":false,"given":"Miranda","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"2026030509350790000_67.3.2500560.1","doi-asserted-by":"crossref","first-page":"649512","DOI":"10.3389\/fcvm.2021.649512","article-title":"Chronic obstructive pulmonary disease and the cardiovascular system: vascular repair and regeneration as a therapeutic target","volume":"8","author":"Karnati","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2026030509350790000_67.3.2500560.2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2214\/ajr.100.2.374","article-title":"Vascular changes in pulmonary emphysema","volume":"100","author":"Jacobson","year":"1967","journal-title":"Am J Roentgenol"},{"key":"2026030509350790000_67.3.2500560.3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/resp.12772","article-title":"Pulmonary vasculature in COPD: the silent component","volume":"21","author":"Blanco","year":"2016","journal-title":"Respirology"},{"key":"2026030509350790000_67.3.2500560.4","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007913"},{"key":"2026030509350790000_67.3.2500560.5","first-page":"128","article-title":"Advances in chronic obstructive pulmonary disease imaging","volume":"6","author":"Dolliver","year":"2020","journal-title":"Barc Respir Netw Rev"},{"key":"2026030509350790000_67.3.2500560.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2009.07.022"},{"key":"2026030509350790000_67.3.2500560.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201301-0162OC"},{"key":"2026030509350790000_67.3.2500560.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200908-1189OC"},{"key":"2026030509350790000_67.3.2500560.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.01.084"},{"key":"2026030509350790000_67.3.2500560.10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1164\/rccm.201712-2426OC","article-title":"Pruning of the pulmonary vasculature in asthma. 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