{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:51:44Z","timestamp":1787064704082,"version":"build-2736575974"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"3","funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["Grant NCKUH 10508003"],"award-info":[{"award-number":["Grant NCKUH 10508003"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,1,31]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    Chronic obstructive pulmonary disease (COPD) is commonly staged according to the percentage of predicted forced expiratory volume in 1\u2005s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    % pred), but other methods have been proposed. In this study we compared the performance of seven staging methods in predicting outcomes.\n                  <\/jats:p>\n                  <jats:p>\n                    We retrospectively studied 296 COPD outpatients. For each patient the disease severity was staged by separately applying the following methods: the criteria proposed by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), quartiles of FEV\n                    <jats:sub>1<\/jats:sub>\n                    % pred and z-score of FEV\n                    <jats:sub>1<\/jats:sub>\n                    , quartiles and specified cut-off points of the ratio of FEV\n                    <jats:sub>1<\/jats:sub>\n                    over height squared ((FEV\n                    <jats:sub>1<\/jats:sub>\n                    \u00b7Ht\n                    <jats:sup>\u22122<\/jats:sup>\n                    )\n                    <jats:sub>A<\/jats:sub>\n                    and (FEV\n                    <jats:sub>1<\/jats:sub>\n                    \u00b7Ht\n                    <jats:sup>\u22122<\/jats:sup>\n                    )\n                    <jats:sub>B<\/jats:sub>\n                    , respectively), and quartiles of the ratio of FEV\n                    <jats:sub>1<\/jats:sub>\n                    over height cubed (FEV\n                    <jats:sub>1<\/jats:sub>\n                    \u00b7Ht\n                    <jats:sup>\u22123<\/jats:sup>\n                    ) and of FEV\n                    <jats:sub>1<\/jats:sub>\n                    quotient (FEV\n                    <jats:sub>1<\/jats:sub>\n                    Q). We evaluated the performance of these methods in predicting the risks of severe acute exacerbation and all-cause mortality.\n                  <\/jats:p>\n                  <jats:p>\n                    Overall, staging based on the reference-independent FEV\n                    <jats:sub>1<\/jats:sub>\n                    Q performed best in predicting the risks of severe acute exacerbation (including frequent exacerbation) and mortality, followed by (FEV\n                    <jats:sub>1<\/jats:sub>\n                    \u00b7Ht\n                    <jats:sup>\u22122<\/jats:sup>\n                    )\n                    <jats:sub>B<\/jats:sub>\n                    . The performance of staging methods could also be influenced by the choice of cut-off values. Future work using large and ethnically diverse populations to refine and validate the cut-off values would enhance the prediction of outcomes.\n                  <\/jats:p>","DOI":"10.1183\/13993003.00577-2017","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T11:08:32Z","timestamp":1518433712000},"page":"1700577","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Comparison of different staging methods for COPD in predicting outcomes"],"prefix":"10.1183","volume":"51","author":[{"given":"Tang-Hsiu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzuen-Ren","family":"Hsiue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hsiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ming","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Lan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung-Zuei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"2024102100210865000_51.3.1700577.1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management and Prevention of COPD 2017. Available from: http:\/\/goldcopd.org\/"},{"key":"2024102100210865000_51.3.1700577.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00135110"},{"key":"2024102100210865000_51.3.1700577.3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"2024102100210865000_51.3.1700577.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03596.x"},{"key":"2024102100210865000_51.3.1700577.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00128711"},{"key":"2024102100210865000_51.3.1700577.6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00086313"},{"key":"2024102100210865000_51.3.1700577.7","first-page":"657","article-title":"A new staging strategy for chronic obstructive pulmonary disease","volume":"2","author":"Miller","year":"2007","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102100210865000_51.3.1700577.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.09.016"},{"key":"2024102100210865000_51.3.1700577.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00025809"},{"key":"2024102100210865000_51.3.1700577.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00008812"},{"key":"2024102100210865000_51.3.1700577.11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12877-015-0013-4","article-title":"Short-term prognostic value of forced expiratory volume in 1 second divided by height cubed in a prospective cohort of people 80 years and older","volume":"15","author":"Turkeshi","year":"2015","journal-title":"BMC Geriatrics"},{"key":"2024102100210865000_51.3.1700577.12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jamda.2016.08.012","article-title":"Predictive value of different expressions of forced expiratory volume in 1 second (FEV1) for adverse outcomes in a cohort of adults aged 80 and older","volume":"18","author":"Hegend\u00f6rfer","year":"2017","journal-title":"J Am Med Dir Assoc"},{"key":"2024102100210865000_51.3.1700577.13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/15412555.2012.654529","article-title":"Using post-bronchodilator FEV1 is better than pre-bronchodilator FEV1 in evaluation of COPD severity","volume":"9","author":"Chen","year":"2012","journal-title":"COPD"},{"key":"2024102100210865000_51.3.1700577.14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00164608"},{"key":"2024102100210865000_51.3.1700577.15","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1714"},{"key":"2024102100210865000_51.3.1700577.16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1677"},{"key":"2024102100210865000_51.3.1700577.17","unstructured":"Blonshine S , Mottram CD , Wanger J . Pulmonary Function Laboratory Management and Procedure Manual. 2nd Edn. New\u00a0York, American Thoracic Society, 2005."},{"key":"2024102100210865000_51.3.1700577.18","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.2.100"},{"key":"2024102100210865000_51.3.1700577.19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6.3810"},{"key":"2024102100210865000_51.3.1700577.20","first-page":"241","article-title":"Risk factors of hospitalization and readmission of patients with COPD exacerbation \u2013 systematic review","volume":"2","author":"Bahadori","year":"2007","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102100210865000_51.3.1700577.21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909883"},{"key":"2024102100210865000_51.3.1700577.22","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S49609"},{"key":"2024102100210865000_51.3.1700577.23","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006171"},{"key":"2024102100210865000_51.3.1700577.24","first-page":"2439","article-title":"Predicting frequent COPD exacerbations using primary care data","volume":"10","author":"Kerkhof","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102100210865000_51.3.1700577.25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5588\/ijtld.15.0441","article-title":"Risk factors for exacerbation in chronic obstructive pulmonary disease: a prospective study","volume":"20","author":"Montserrat-Capdevila","year":"2016","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102100210865000_51.3.1700577.26","first-page":"21","article-title":"Exacerbations of COPD","volume":"11","author":"Pavord","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102100210865000_51.3.1700577.27","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/resp.12780","article-title":"Acute exacerbation of COPD","volume":"21","author":"Ko","year":"2016","journal-title":"Respirology"},{"key":"2024102100210865000_51.3.1700577.28","first-page":"895","article-title":"Predictors of mortality in chronic obstructive pulmonary disease: a 15-year follow-up study","volume":"119","author":"Traver","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"2024102100210865000_51.3.1700577.29","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1986.133.1.14"},{"key":"2024102100210865000_51.3.1700577.30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021322"},{"key":"2024102100210865000_51.3.1700577.31","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-98"},{"key":"2024102100210865000_51.3.1700577.32","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00024804"},{"key":"2024102100210865000_51.3.1700577.33","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1677OC"},{"key":"2024102100210865000_51.3.1700577.34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1383OC"},{"key":"2024102100210865000_51.3.1700577.35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1440-1843.2010.01844.x","article-title":"Respiratory health issues in the Asia\u2013Pacific region: an overview","volume":"16","author":"Jamrozik","year":"2011","journal-title":"Respirology"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00577-2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:50:26Z","timestamp":1740361826000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00577-2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,15]]},"published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1183\/13993003.00577-2017"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00577-2017","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]}}}