{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:17:11Z","timestamp":1791476231040,"version":"4.3.4"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"6","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publications.ersnet.org\/user-licence"}],"funder":[{"name":"IdEx InFibrex Universit\u00e9 Paris Cit\u00e9","award":["ANR 18 IDEX 0001"],"award-info":[{"award-number":["ANR 18 IDEX 0001"]}]},{"DOI":"10.13039\/100001009","name":"Bristol Myers Squibb Foundation","doi-asserted-by":"publisher","award":["IM101-647"],"award-info":[{"award-number":["IM101-647"]}],"id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL168126"],"award-info":[{"award-number":["R01HL168126"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031376","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Rhumatologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2025,8,16]]},"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Shorter leukocyte telomere length (LTL) has been reported in patients with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) and linked to increased disease severity and mortality in idiopathic pulmonary fibrosis, which shares similarities with RA-ILD. We aimed to evaluate the impact of short LTL on baseline respiratory disease severity, disease progression and survival in patients with RA-ILD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients diagnosed with RA-ILD following multidisciplinary assessment were enrolled in a prospective French observational study. LTL was measured at enrolment using qPCR. Short LTL was defined as age-adjusted LTL &lt;10th percentile. Lung disease progression was defined as death, lung transplantation or functional respiratory decline (absolute decrease in forced vital capacity (FVC) \u22655% predicted or diffusing capacity of the lung for carbon monoxide (\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>LCO<\/jats:sub>\n                      ) \u226510% predicted).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 101 patients with RA-ILD, 46% were male, mean\u00b1\n                      <jats:sc>sd<\/jats:sc>\n                      age at enrolment was 66\u00b110\u2005years and 43 (43%) had short LTL. Patients with short LTL had lower FVC % predicted (82%\n                      <jats:italic>versus<\/jats:italic>\n                      93%) and\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>LCO<\/jats:sub>\n                      % predicted (49%\n                      <jats:italic>versus<\/jats:italic>\n                      63%) at enrolment, and greater 12-month decline in FVC % predicted and\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>LCO<\/jats:sub>\n                      % predicted in mixed effects models (\u22127.7% (95% CI \u221211.6\u2013\u2009\u22123.8%); p&lt;0.001 and \u22124.5 (95% CI \u22127.2\u2013\u2009\u22121.8%); p=0.001, respectively), although transplant-free survival was similar over a median (interquartile range) follow-up of 3.6 (1.8\u20137.0)\u2005years. Lung disease progression was observed within 12\u2005months of enrolment in 33 (33%) patients, more frequently in patients with short LTL (47%\n                      <jats:italic>versus<\/jats:italic>\n                      22%; univariate p=0.011) and lower FVC at enrolment. Multivariate logistic regression identified lower FVC and short LTL as predictors of 12-month progression (OR 0.97 (95% CI 0.94\u20131.00); p=0.031 and OR 2.80 (95% CI 0.99\u20138.29); p=0.056, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Short LTL is associated with baseline severity and 12-month progression in RA-ILD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.00587-2025","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T15:18:14Z","timestamp":1758208694000},"page":"2500587","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Short telomere length is associated with accelerated lung disease progression in rheumatoid arthritis-associated interstitial lung 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