{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:44:38Z","timestamp":1787161478214,"version":"build-2736575974"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 HL143034"],"award-info":[{"award-number":["K01 HL143034"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 HL135818"],"award-info":[{"award-number":["R35 HL135818"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA167552"],"award-info":[{"award-number":["U01 CA167552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA176726"],"award-info":[{"award-number":["U01 CA176726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA186107"],"award-info":[{"award-number":["UM1 CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2021,6,10]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reduced physical activity and increased sedentary behaviour may independently contribute to the development of obstructive sleep apnoea (OSA) through increased adiposity, inflammation, insulin resistance and body fluid retention. However, epidemiological evidence remains sparse and is primarily limited to cross-sectional studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively followed 50\u200a332 women from the Nurses\u2019 Health Study (2002\u20132012), 68\u200a265 women from the Nurses\u2019 Health Study II (1995\u20132013) and 19\u200a320 men from the Health Professionals Follow-up Study (1996\u20132012). Recreational physical activity (quantified by metabolic equivalent of task (MET)-h per week) and sitting time spent watching TV and at work\/away from home were assessed by questionnaires every 2\u20134\u2005years. Physician-diagnosed OSA was identified by validated self-report. Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals for OSA incidence associated with physical activity and sedentary behaviour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During 2\u200a004\u200a663 person-years of follow-up, we documented 8733 incident OSA cases. After adjusting for potential confounders, the pooled HR for OSA comparing participants with \u226536.0\n                      <jats:italic>versus<\/jats:italic>\n                      &lt;6.0\u2005MET-h per week of physical activity was 0.46 (95% CI 0.43\u20130.50; p\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001). Compared with participants spending &lt;4.0\u2005h per week sitting watching TV, the multivariable-adjusted HR was 1.78 (95% CI 1.60\u20131.98) for participants spending \u226528.0\u2005h per week (p\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001). The comparable HR was 1.49 (95% CI 1.38\u20131.62) for sitting hours at work\/away from home (p\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001). With additional adjustment for several metabolic factors, including body mass index and waist circumference, the associations with physical activity and sitting hours at work\/away from home were attenuated but remained significant (p\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001), whereas the association with sitting hours watching TV was no longer statistically significant (p\n                      <jats:sub>trend<\/jats:sub>\n                      =0.18).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher levels of physical activity and fewer sedentary hours were associated with lower OSA incidence. The potential mediating role of metabolic factors in the association between sedentary behaviour and OSA incidence may depend on the type of sedentary behaviour. Our results suggest that promoting an active lifestyle may reduce OSA incidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.00606-2021","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T20:25:36Z","timestamp":1626899136000},"page":"2100606","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Physical activity, sedentary behaviour and incidence of obstructive sleep apnoea in three prospective US cohorts"],"prefix":"10.1183","volume":"59","author":[{"given":"Yue","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir 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