{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:21:27Z","timestamp":1793262087951,"version":"4.5.0"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"name":"Department of Internal Medicine and Department of Clinical Biochemistry at Herlev and Gentofte Hospital"},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008366","name":"Danmarks Lungeforening","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,6,4]]},"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>We investigated whether the combination of increased exhaled nitric oxide fraction (<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>) level and blood eosinophil count had an additive value in chronic airway disease in the general population.<\/jats:p><jats:p>We included 4677 individuals aged 20\u2013100\u2005years from the Copenhagen General Population Study. Based on pre- and post-bronchodilator spirometry, self-reported asthma and smoking history, participants were subdivided into healthy never-smokers (n=1649), healthy ever-smokers (n=1581), asthma (n=449), chronic obstructive pulmonary disease (COPD) (n=404), asthma\u2013COPD overlap (ACO) (n=138) and nonspecific airflow limitation (n=456).<\/jats:p><jats:p>Compared to individuals with<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>&lt;25\u2005ppb and blood eosinophils &lt;0.3\u00d710<jats:sup>9<\/jats:sup>\u2005cells\u00b7L<jats:sup>\u22121<\/jats:sup>, age- and sex-adjusted odds ratios (95% CI) for wheezing were 1.54 (1.29\u20131.84) for individuals with<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>\u226525\u2005ppb or blood eosinophils \u22650.3\u00d710<jats:sup>9<\/jats:sup>\u2005cells\u00b7L<jats:sup>\u22121<\/jats:sup>and 2.14 (1.47\u20133.10) for individuals with<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>\u226525\u2005ppb and blood eosinophils \u22650.3\u00d710<jats:sup>9<\/jats:sup>\u2005cells\u00b7L<jats:sup>\u22121<\/jats:sup>. Corresponding odds ratios were 1.13 (0.91\u20131.41) and 1.83 (1.20\u20132.79) for sputum production, 1.54 (1.22\u20131.94) and 3.26 (2.16\u20134.94) for asthma, 1.03 (0.80\u20131.32) and 0.67 (0.36\u20131.27) for COPD and 1.32 (0.88\u20131.96) and 2.14 (1.05\u20134.36) for ACO. Among individuals reporting respiratory symptoms, predicting the type of chronic airway disease did not differ between the two biomarkers and did not improve by combining them.<\/jats:p><jats:p>Combination of<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>and blood eosinophils may have an additive value in characterising chronic airway disease in the general population but still needs to be investigated further with regard to clinical application.<\/jats:p>","DOI":"10.1183\/13993003.00616-2018","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T11:56:01Z","timestamp":1528977361000},"page":"1800616","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Combined value of exhaled nitric oxide and blood eosinophils in chronic airway disease: the Copenhagen General Population Study"],"prefix":"10.1183","volume":"52","author":[{"given":"Yunus","family":"\u00c7olak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaib","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f8rge G.","family":"Nordestgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob\u00a0L.","family":"Marott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,6,14]]},"reference":[{"key":"2024102100312600000_52.2.1800616.1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315609251"},{"key":"2024102100312600000_52.2.1800616.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30879-6"},{"key":"2024102100312600000_52.2.1800616.3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/cea.12881","article-title":"The current and future role of biomarkers in type 2 cytokine-mediated asthma management","volume":"47","author":"Pavord","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"2024102100312600000_52.2.1800616.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106469"},{"key":"2024102100312600000_52.2.1800616.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.007"},{"key":"2024102100312600000_52.2.1800616.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304048"},{"key":"2024102100312600000_52.2.1800616.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808991"},{"key":"2024102100312600000_52.2.1800616.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403290"},{"key":"2024102100312600000_52.2.1800616.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60988-X"},{"key":"2024102100312600000_52.2.1800616.10","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jaci.2016.01.044","article-title":"Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity","volume":"138","author":"Malinovschi","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2024102100312600000_52.2.1800616.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.045"},{"key":"2024102100312600000_52.2.1800616.12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201509-1869OC"},{"key":"2024102100312600000_52.2.1800616.13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S2213-2600(17)30119-4","article-title":"Prognosis of asymptomatic and symptomatic, undiagnosed COPD in the general population in Denmark: a prospective cohort study","volume":"5","author":"\u00c7olak","year":"2017","journal-title":"Lancet Respir Med"},{"key":"2024102100312600000_52.2.1800616.14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"2024102100312600000_52.2.1800616.15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"2024102100312600000_52.2.1800616.16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S2213-2600(15)00367-7","article-title":"Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study","volume":"3","author":"Price","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2024102100312600000_52.2.1800616.17","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S2213-2600(16)00098-9","article-title":"Long-term prognosis of asthma, chronic obstructive pulmonary disease, and asthma-chronic obstructive pulmonary disease overlap in the Copenhagen City Heart study: a prospective population-based analysis","volume":"4","author":"Lange","year":"2016","journal-title":"Lancet Respir Med"},{"key":"2024102100312600000_52.2.1800616.18","unstructured":"Global Initiative for Asthma (GINA), Global Initiative for Chronic Obstructive Lung Disease (GOLD). 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