{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:37:45Z","timestamp":1789519065126,"version":"build-2803163510"},"reference-count":20,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL08039"],"award-info":[{"award-number":["R01 HL08039"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL129795"],"award-info":[{"award-number":["R01 HL129795"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2023,5,8]]},"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1183\/13993003.00619-2023","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T08:25:15Z","timestamp":1685003115000},"page":"2300619","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Towards a better mucolytic"],"prefix":"10.1183","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-1847","authenticated-orcid":false,"given":"Burton F.","family":"Dickey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-7314","authenticated-orcid":false,"given":"Christopher M.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"2024102012271383000_61.5.2300619.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910061"},{"key":"2024102012271383000_61.5.2300619.2","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1152\/physrev.00004.2021","article-title":"Physiology and pathophysiology of human airway mucus","volume":"102","author":"Hill","year":"2022","journal-title":"Physiol Rev"},{"key":"2024102012271383000_61.5.2300619.3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1164\/rccm.201808-1444ED","article-title":"Dawn of a new era in the diagnosis and treatment of airway mucus dysfunction","volume":"199","author":"Kim","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102012271383000_61.5.2300619.4","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201806-368AW"},{"key":"2024102012271383000_61.5.2300619.5","doi-asserted-by":"crossref","first-page":"102248","DOI":"10.1016\/j.coph.2022.102248","article-title":"Mucus-targeting therapies of defective mucus clearance for cystic fibrosis: a short review","volume":"65","author":"Figueira","year":"2022","journal-title":"Curr Opin Pharmacol"},{"key":"2024102012271383000_61.5.2300619.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1813799"},{"key":"2024102012271383000_61.5.2300619.7","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1164\/rccm.202207-1306ED","article-title":"Airway mucus dysfunction in COVID-19","volume":"206","author":"Dickey","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102012271383000_61.5.2300619.8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010525"},{"key":"2024102012271383000_61.5.2300619.9","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/s41586-022-04543-1","article-title":"Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides","volume":"603","author":"Lai","year":"2022","journal-title":"Nature"},{"key":"2024102012271383000_61.5.2300619.10","doi-asserted-by":"crossref","first-page":"eabm9718","DOI":"10.1126\/sciadv.abm9718","article-title":"Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis","volume":"8","author":"Kato","year":"2022","journal-title":"Sci Adv"},{"key":"2024102012271383000_61.5.2300619.11","doi-asserted-by":"crossref","first-page":"749077","DOI":"10.3389\/fphys.2021.749077","article-title":"Airway epithelial innate immunity","volume":"12","author":"Johnston","year":"2021","journal-title":"Front Physiol"},{"key":"2024102012271383000_61.5.2300619.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.07.027"},{"key":"2024102012271383000_61.5.2300619.13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1164\/rccm.201802-0245OC","article-title":"An improved inhaled mucolytic to treat airway muco-obstructive diseases","volume":"199","author":"Ehre","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102012271383000_61.5.2300619.14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.2.9611001"},{"key":"2024102012271383000_61.5.2300619.15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41467-020-20499-0","article-title":"Disulfide disruption reverses mucus dysfunction in allergic airway disease","volume":"12","author":"Morgan","year":"2021","journal-title":"Nat Commun"},{"key":"2024102012271383000_61.5.2300619.16","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02022-2022"},{"key":"2024102012271383000_61.5.2300619.17","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1016\/S1569-1993(22)01094-3","article-title":"Why are mucins so gigantic, and is it rational to sever them to aid mucus clearance?","volume":"21","author":"Livraghi-Butrico","year":"2022","journal-title":"J Cystic Fibrosis"},{"key":"2024102012271383000_61.5.2300619.18","doi-asserted-by":"crossref","first-page":"L910","DOI":"10.1152\/ajplung.00274.2018","article-title":"Buffer drains and mucus is transported upward in a tilted mucus clearance assay","volume":"315","author":"Carpenter","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2024102012271383000_61.5.2300619.19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7281"},{"key":"2024102012271383000_61.5.2300619.20","doi-asserted-by":"publisher","DOI":"10.1038\/nature12807"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00619-2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:14:00Z","timestamp":1740381240000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00619-2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,25]]},"published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1183\/13993003.00619-2023"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00619-2023","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}