{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:43:30Z","timestamp":1791387810572,"version":"4.3.3"},"reference-count":44,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,5,4]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>This study aimed to investigate associations between obstructive sleep apnoea (OSA) and cortical thickness in older adults with subjective and objective cognitive difficulties, who are considered \u201cat-risk\u201d for dementia.<\/jats:p>\n                  <jats:p>83 middle-aged to older adults (51\u201388\u2005years) underwent neuropsychological testing, polysomnography assessment of OSA and a structural magnetic resonance imaging brain scan. A principal components analysis was performed on OSA measures. Cortical thickness and subcortical volumes were compared to extracted components of \u201coxygen desaturation\u201d and \u201csleep disturbance\u201d.<\/jats:p>\n                  <jats:p>Oxygen desaturation was significantly related to reduced cortical thickness in the bilateral temporal lobes (left: r=\u22120.44, p&lt;0.001; right: r=\u22120.39, p=0.003). Conversely, sleep disturbance was associated with increased thickness in the right postcentral gyrus (r=0.48, p&lt;0.001), pericalcarine (r=0.50, p=0.005) and pars opercularis (r=0.46, p=0.009) and increased volume of the hippocampus and amygdala. Decreased thickness in the bilateral temporal regions was associated with reduced verbal encoding (r=0.28, p=0.010).<\/jats:p>\n                  <jats:p>Given the clinical significance of this sample in terms of dementia prevention, these changes in grey matter reveal how OSA might contribute to neurodegenerative processes in older adults.<\/jats:p>","DOI":"10.1183\/13993003.00740-2018","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T19:49:48Z","timestamp":1530733788000},"page":"1800740","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":86,"title":["Structural brain correlates of obstructive sleep apnoea in older adults at risk for dementia"],"prefix":"10.1183","volume":"52","author":[{"given":"Nathan E.","family":"Cross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Memarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantel L.","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Paquola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"LaMonica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D'Rozario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon\u00a0J.G.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian B.","family":"Hickie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald R.","family":"Grunstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon\u00a0L.","family":"Naismith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"2024101909502939000_52.1.1800740.1","doi-asserted-by":"crossref","first-page":"e78655","DOI":"10.1371\/journal.pone.0078655","article-title":"Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"},{"key":"2024101909502939000_52.1.1800740.2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001566"},{"key":"2024101909502939000_52.1.1800740.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70136-X"},{"key":"2024101909502939000_52.1.1800740.4","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.26.1.43.23929"},{"key":"2024101909502939000_52.1.1800740.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241224"},{"key":"2024101909502939000_52.1.1800740.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5982"},{"key":"2024101909502939000_52.1.1800740.7","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3233\/JAD-161287","article-title":"Is sleep disruption a risk factor for Alzheimer's disease?","volume":"58","author":"Macedo","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"2024101909502939000_52.1.1800740.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201005-0693OC"},{"key":"2024101909502939000_52.1.1800740.9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200201-050OC"},{"key":"2024101909502939000_52.1.1800740.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2008.00705.x"},{"key":"2024101909502939000_52.1.1800740.11","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00159-X"},{"key":"2024101909502939000_52.1.1800740.12","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20650"},{"key":"2024101909502939000_52.1.1800740.13","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1164\/rccm.201606-1271OC","article-title":"Gray matter hypertrophy and thickening with obstructive sleep apnea in middle-aged and older adults","volume":"195","author":"Baril","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101909502939000_52.1.1800740.14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"2024101909502939000_52.1.1800740.15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2012.02.010","article-title":"Voxelwise meta-analysis of gray matter anomalies in Alzheimer's disease and mild cognitive impairment using anatomic likelihood estimation","volume":"316","author":"Yang","year":"2012","journal-title":"J Neurol Sci"},{"key":"2024101909502939000_52.1.1800740.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-011-0333-x"},{"key":"2024101909502939000_52.1.1800740.17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1017\/S1041610216002349","article-title":"Hippocampal and entorhinal structures in subjective memory impairment: a combined MRI volumetric and DTI study","volume":"29","author":"Ryu","year":"2017","journal-title":"Int Psychogeriatr"},{"key":"2024101909502939000_52.1.1800740.18","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.078683"},{"key":"2024101909502939000_52.1.1800740.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.005"},{"key":"2024101909502939000_52.1.1800740.20","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"2024101909502939000_52.1.1800740.21","unstructured":"First MB , Williams JBW , Spitzer RL , et\u00a0al. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Clinical Trials Version (SCID-CT). New\u00a0York, Biometrics Research, New\u00a0York State Psychiatric Institute, 2007."},{"key":"2024101909502939000_52.1.1800740.22","doi-asserted-by":"publisher","DOI":"10.1300\/J018v05n01_09"},{"key":"2024101909502939000_52.1.1800740.23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11065-017-9344-6","article-title":"Is obstructive sleep apnoea related to neuropsychological function in healthy older adults? A systematic review and meta-analysis","volume":"27","author":"Cross","year":"2017","journal-title":"Neuropsychol Rev"},{"key":"2024101909502939000_52.1.1800740.24","unstructured":"Lezak M . Neuropsychological Assessment. New\u00a0York, Oxford University Press, 1982."},{"key":"2024101909502939000_52.1.1800740.25","unstructured":"Senior G. Analysing RAVLT Learning and Serial Position Curves using Mahalanobis Distance. Toowoomba, QLD, Australia, University of Southern Queensland, 1999."},{"key":"2024101909502939000_52.1.1800740.26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"2024101909502939000_52.1.1800740.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"2024101909502939000_52.1.1800740.28","unstructured":"Iber C , Ancoli-Israel S , Chesson AJ , et\u00a0al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Westchester, IL, American Academy of Sleep Medicine, 2007."},{"key":"2024101909502939000_52.1.1800740.29","first-page":"161","article-title":"Is apnea-hypopnea index a proper measure for obstructive sleep apnea severity?","volume":"27","author":"Asghari","year":"2013","journal-title":"Med J Islam Repub Iran"},{"key":"2024101909502939000_52.1.1800740.30","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00004-8"},{"key":"2024101909502939000_52.1.1800740.31","doi-asserted-by":"crossref","first-page":"899","DOI":"10.5665\/sleep.5650","article-title":"Association of anterior cingulate glutathione with sleep apnea in older adults at-risk for dementia","volume":"39","author":"Duffy","year":"2016","journal-title":"Sleep"},{"key":"2024101909502939000_52.1.1800740.32","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.57"},{"key":"2024101909502939000_52.1.1800740.33","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S2213-2600(15)00090-9","article-title":"Sleep apnoea and the brain: a complex relationship","volume":"3","author":"Rosenzweig","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2024101909502939000_52.1.1800740.34","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3233\/JAD-161047","article-title":"Amyloid burden in obstructive sleep apnea","volume":"59","author":"Yun","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"2024101909502939000_52.1.1800740.35","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1164\/rccm.201704-0704OC","article-title":"Obstructive sleep apnea severity affects amyloid burden in cognitively normal elderly. A longitudinal study","volume":"197","author":"Sharma","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101909502939000_52.1.1800740.36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12967-016-0887-8","article-title":"Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment","volume":"14","author":"Lin","year":"2016","journal-title":"J Transl Med"},{"key":"2024101909502939000_52.1.1800740.37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083173"},{"key":"2024101909502939000_52.1.1800740.38","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3324"},{"key":"2024101909502939000_52.1.1800740.39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuron.2017.11.020","article-title":"Old brains come uncoupled in sleep: slow wave-spindle synchrony, brain atrophy, and forgetting","volume":"97","author":"Helfrich","year":"2018","journal-title":"Neuron"},{"key":"2024101909502939000_52.1.1800740.40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neubiorev.2017.12.004","article-title":"Obstructive sleep apnoea and Alzheimer's disease: in search of shared pathomechanisms","volume":"86","author":"Polsek","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"2024101909502939000_52.1.1800740.41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1115"},{"key":"2024101909502939000_52.1.1800740.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.05.002"},{"key":"2024101909502939000_52.1.1800740.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.10.019"},{"key":"2024101909502939000_52.1.1800740.44","doi-asserted-by":"publisher","DOI":"10.1177\/1533317515592331"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00740-2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:58:39Z","timestamp":1740362319000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00740-2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,7,4]]},"published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1183\/13993003.00740-2018"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00740-2018","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}