{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:24:49Z","timestamp":1787934289794,"version":"build-2784847793"},"reference-count":32,"publisher":"European Respiratory Society (ERS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publications.ersnet.org\/user-licence"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2025,5,6]]},"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1183\/13993003.00778-2025","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T08:20:20Z","timestamp":1749111620000},"page":"2500778","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Theratyping in cystic fibrosis: filling the knowledge gaps"],"prefix":"10.1183","volume":"65","author":[{"given":"Iwona","family":"Pranke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5537-9482","authenticated-orcid":false,"given":"Isabelle","family":"Sermet-Gaudelus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"2025060501201281000_65.6.2500778.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"2025060501201281000_65.6.2500778.2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/17476348.2024.2357210","article-title":"Unmet challenges in cystic fibrosis treatment with modulators","volume":"18","author":"Corrao","year":"2024","journal-title":"Expert Rev Respir Med"},{"key":"2025060501201281000_65.6.2500778.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.05.004"},{"key":"2025060501201281000_65.6.2500778.4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jcf.2019.06.010","article-title":"Theranostics by testing CFTR modulators in patient-derived materials: the current status and a proposal for subjects with rare CFTR mutations","volume":"18","author":"Amaral","year":"2019","journal-title":"J Cyst Fibros"},{"key":"2025060501201281000_65.6.2500778.5","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/jpm12081321","article-title":"Advances in preclinical in vitro models for the translation of precision medicine for cystic fibrosis","volume":"12","author":"Silva","year":"2022","journal-title":"J Pers Med"},{"key":"2025060501201281000_65.6.2500778.6","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.3390\/ijms22094448","article-title":"Nasal epithelial cell-based models for individualized study in cystic fibrosis","volume":"22","author":"Keegan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025060501201281000_65.6.2500778.7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1164\/rccm.201808-1436LE","article-title":"Might brushed nasal cells be a surrogate for CFTR modulator clinical response?","volume":"199","author":"Pranke","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2025060501201281000_65.6.2500778.8","doi-asserted-by":"crossref","first-page":"101419","DOI":"10.1016\/j.xpro.2022.101419","article-title":"Isolation, cultivation, and application of primary respiratory epithelial cells obtained by nasal brushing, polyp samples, or lung explants","volume":"3","author":"Golec","year":"2022","journal-title":"STAR Protoc"},{"key":"2025060501201281000_65.6.2500778.9","first-page":"e63409","article-title":"Primary human nasal epithelial cells: biobanking in the context of precision medicine","volume":"182","author":"Kelly","year":"2022","journal-title":"J Vis Exp"},{"key":"2025060501201281000_65.6.2500778.10","unstructured":"European Cystic Fibrosis Society Clinical Trials Network. Standard Operating Procedure 4.1\/001\/V2: Isolation, Cultivation, and Application of Primary Respiratory Epithelial Cells Obtained by Nasal Brushing. Karup, ECFS Clinical Trials Network, 2024. Available on request from ecfs-ctn@uzleuven.be"},{"key":"2025060501201281000_65.6.2500778.11","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0325OC"},{"key":"2025060501201281000_65.6.2500778.12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00384.2011"},{"key":"2025060501201281000_65.6.2500778.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07504-1"},{"key":"2025060501201281000_65.6.2500778.14","doi-asserted-by":"crossref","first-page":"e99385","DOI":"10.1172\/jci.insight.99385","article-title":"Brushed nasal epithelial cells are a surrogate for bronchial epithelial CFTR studies","volume":"3","author":"Brewington","year":"2018","journal-title":"JCI Insight"},{"key":"2025060501201281000_65.6.2500778.15","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fped.2020.00536","article-title":"Functional profiling of CFTR-directed therapeutics using pediatric patient-derived nasal epithelial cell models","volume":"8","author":"Park","year":"2020","journal-title":"Front Pediatr"},{"key":"2025060501201281000_65.6.2500778.16","doi-asserted-by":"crossref","first-page":"151231","DOI":"10.1016\/j.ejcb.2022.151231","article-title":"Cell function and identity revealed by comparative scRNA-seq analysis in human nasal, bronchial and epididymis epithelia","volume":"101","author":"Paranjapye","year":"2022","journal-title":"Eur J Cell Biol"},{"key":"2025060501201281000_65.6.2500778.17","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02457-2017"},{"key":"2025060501201281000_65.6.2500778.18","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1513\/AnnalsATS.202001-082RL","article-title":"Correlation between ivacaftor-induced CFTR activation in airway epithelial cells and improved lung function: a proof-of-concept study","volume":"17","author":"Debley","year":"2020","journal-title":"Ann Am Thorac Soc"},{"key":"2025060501201281000_65.6.2500778.19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ppul.23659","article-title":"In vivo and in vitro ivacaftor response in cystic fibrosis patients with residual CFTR function: N-of-1 studies","volume":"52","author":"McGarry","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"2025060501201281000_65.6.2500778.20","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00110-2023"},{"key":"2025060501201281000_65.6.2500778.21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512365"},{"key":"2025060501201281000_65.6.2500778.22","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01855-2024"},{"key":"2025060501201281000_65.6.2500778.23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202110-2249OC"},{"key":"2025060501201281000_65.6.2500778.24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/humu.23389","article-title":"Cis variants identified in F508del complex alleles modulate CFTR channel rescue by small molecules","volume":"39","author":"Baatallah","year":"2018","journal-title":"Hum Mutat"},{"key":"2025060501201281000_65.6.2500778.25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/ph17030367","article-title":"Unity is strength: the mutual alliance between CFTR and SLC26A6 as therapeutic opportunity in cystic fibrosis","volume":"17","author":"Pariano","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"2025060501201281000_65.6.2500778.26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00828"},{"key":"2025060501201281000_65.6.2500778.27","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00746-2023"},{"key":"2025060501201281000_65.6.2500778.28","doi-asserted-by":"crossref","first-page":"e14007","DOI":"10.1111\/petr.14007","article-title":"To treat or not to treat: CFTR modulators after lung transplantation","volume":"25","author":"Hayes","year":"2021","journal-title":"Pediatr Transplant"},{"key":"2025060501201281000_65.6.2500778.29","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.bbadis.2019.01.029","article-title":"Extent of rescue of F508del-CFTR function by VX-809 and VX-770 in human nasal epithelial cells correlates with SNP rs7512462 in SLC26A9 gene in F508del\/F508del cystic fibrosis patients","volume":"1865","author":"Kmit","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2025060501201281000_65.6.2500778.30","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3849"},{"key":"2025060501201281000_65.6.2500778.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2024.02.006"},{"key":"2025060501201281000_65.6.2500778.32","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00448-2020"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00778-2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T08:20:25Z","timestamp":1749111625000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00778-2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,5]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1183\/13993003.00778-2025"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00778-2025","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}