{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:26:15Z","timestamp":1790439975701,"version":"4.1.0"},"reference-count":19,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2020,5,8]]},"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The duration of viral shedding is central to the guidance of decisions about isolation precautions and antiviral treatment. However, studies regarding the risk factors associated with prolonged shedding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the impact of lopinavir\/ritonavir (LPV\/r) treatment on viral shedding remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from all SARS-CoV-2 infected patients who were admitted to isolation wards and had reverse transcription PCR conversion at the No. 3 People's Hospital of Hubei province, China, between 31 January and 9 March 2020. We compared clinical characteristics and SARS-CoV-2 RNA shedding between patients initiated with LPV\/r treatment and those without. Logistic regression analysis was employed to evaluate the risk factors associated with prolonged viral shedding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 120 patients, the median age was 52\u2005years, 54 (45%) were male and 78 (65%) received LPV\/r treatment. The median duration of SARS-CoV-2 RNA detection from symptom onset was 23\u2005days (interquartile range 18\u201332\u2005days). Older age (OR 1.03, 95% CI 1.00\u20131.05; p=0.03) and the lack of LPV\/r treatment (OR 2.42, 95% CI 1.10\u20135.36; p=0.029) were independent risk factors for prolonged SARS-CoV-2 RNA shedding. Patients who initiated LPV\/r treatment within 10\u2005days from symptom onset, but not initiated from day 11 onwards, had significantly shorter viral shedding duration compared with those without LPV\/r treatment (median 19\u2005days\n                      <jats:italic>versus<\/jats:italic>\n                      28.5\u2005days; log-rank p&lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Older age and the lack of LPV\/r treatment were independently associated with prolonged SARS-CoV-2 RNA shedding in patients with coronavirus disease 2019 (COVID-19). Earlier administration of LPV\/r treatment could shorten viral shedding duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.00799-2020","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T16:37:04Z","timestamp":1589906224000},"page":"2000799","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":117,"title":["Factors associated with prolonged viral shedding and impact of lopinavir\/ritonavir treatment in hospitalised non-critically ill patients with SARS-CoV-2 infection"],"prefix":"10.1183","volume":"56","author":[{"given":"Dan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-nan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-tang","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-hua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"2024102101415435000_56.1.2000799.1","unstructured":"World Health Organization. Coronavirus Disease 2019 (COVID-19): Situation Report \u2013 94 . www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200423-sitrep-94-covid-19.pdf Date last updated: 23 April 2020."},{"key":"2024102101415435000_56.1.2000799.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"2024102101415435000_56.1.2000799.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"2024102101415435000_56.1.2000799.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"2024102101415435000_56.1.2000799.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"2024102101415435000_56.1.2000799.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4372"},{"key":"2024102101415435000_56.1.2000799.7","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00398-2020"},{"key":"2024102101415435000_56.1.2000799.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"2024102101415435000_56.1.2000799.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001282"},{"key":"2024102101415435000_56.1.2000799.10","unstructured":"National Health Commission of the People's Republic of China. Chinese management guideline for COVID-19 (version 6.0). www.nhc.gov.cn\/yzygj\/s7653p\/202002\/8334a8326dd94d329df351d7da8aefc2\/files\/b218cfeb1bc54639af227f922bf6b817.pdf Date last updated: 19 February 2020."},{"key":"2024102101415435000_56.1.2000799.11","doi-asserted-by":"publisher","DOI":"10.3201\/eid2602.190697"},{"key":"2024102101415435000_56.1.2000799.12","doi-asserted-by":"crossref","unstructured":"Wu C , Chen X , Cai Y , et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020; in press [ https:\/\/doi.org\/10.1001\/jamainternmed.2020.0994 ].","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"2024102101415435000_56.1.2000799.13","doi-asserted-by":"publisher","DOI":"10.1086\/432007"},{"key":"2024102101415435000_56.1.2000799.14","doi-asserted-by":"publisher","DOI":"10.1086\/503843"},{"key":"2024102101415435000_56.1.2000799.15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41467-019-13940-6","article-title":"Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV","volume":"11","author":"Sheahan","year":"2020","journal-title":"Nat Comm"},{"key":"2024102101415435000_56.1.2000799.16","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.2003.012658"},{"key":"2024102101415435000_56.1.2000799.17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03011-14"},{"key":"2024102101415435000_56.1.2000799.18","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv392"},{"key":"2024102101415435000_56.1.2000799.19","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy115"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00799-2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T02:33:55Z","timestamp":1740364435000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00799-2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,7,16]]},"published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1183\/13993003.00799-2020"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00799-2020","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.22.20040832","asserted-by":"object"}]},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]}}}