{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:30:43Z","timestamp":1789749043831,"version":"4.0.1"},"reference-count":229,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,1,23]]},"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Connective tissue diseases encompass a wide range of heterogeneous disorders characterised by immune-mediated chronic inflammation often leading to tissue damage, collagen deposition and possible loss of function of the target organ. Lung involvement is a common complication of connective tissue diseases. Depending on the underlying disease, various thoracic compartments can be involved but interstitial lung disease is a major contributor to morbidity and mortality. Interstitial lung disease, pulmonary hypertension or both are found most commonly in systemic sclerosis. In the elderly, the prevalence of connective tissue diseases continues to rise due to both longer life expectancy and more effective and better-tolerated treatments. In the geriatric population, connective tissue diseases are almost invariably accompanied by age-related comorbidities, and disease- and treatment-related complications, which contribute to the significant morbidity and mortality associated with these conditions, and complicate treatment decision-making. Connective tissue diseases in the elderly represent a growing concern for healthcare providers and an increasing burden of global health resources worldwide. A better understanding of the mechanisms involved in the regulation of the immune functions in the elderly and evidence-based guidelines specifically designed for this patient population are instrumental to improving the management of connective tissue diseases in elderly patients.<\/jats:p>","DOI":"10.1183\/13993003.00829-2015","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:39:03Z","timestamp":1456439943000},"page":"1535-1558","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":73,"title":["Connective tissue diseases, multimorbidity and the ageing lung"],"prefix":"10.1183","volume":"47","author":[{"given":"Paolo","family":"Spagnolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Cordier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"2024102023545989000_47.5.1535.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.149"},{"key":"2024102023545989000_47.5.1535.2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2669"},{"key":"2024102023545989000_47.5.1535.3","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(70)90054-8"},{"key":"2024102023545989000_47.5.1535.4","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.212"},{"key":"2024102023545989000_47.5.1535.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-012-1115-4"},{"key":"2024102023545989000_47.5.1535.6","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X104641"},{"key":"2024102023545989000_47.5.1535.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61079-4"},{"key":"2024102023545989000_47.5.1535.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.82"},{"key":"2024102023545989000_47.5.1535.9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204627"},{"key":"2024102023545989000_47.5.1535.10","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.92"},{"key":"2024102023545989000_47.5.1535.11","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000110"},{"key":"2024102023545989000_47.5.1535.12","unstructured":"Mayes MD , Reveille JD . Epidemiology, demographics and genetics. In : Clements PJ , Furst DE , eds. Systemic Sclerosis. 2nd Edn. Philadelphia, Lippincott, 2004; pp. 1\u201315."},{"key":"2024102023545989000_47.5.1535.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.04.031"},{"key":"2024102023545989000_47.5.1535.14","doi-asserted-by":"publisher","DOI":"10.1002\/art.24525"},{"key":"2024102023545989000_47.5.1535.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400309"},{"key":"2024102023545989000_47.5.1535.16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-74-5-714"},{"key":"2024102023545989000_47.5.1535.17","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400421"},{"key":"2024102023545989000_47.5.1535.18","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100956"},{"key":"2024102023545989000_47.5.1535.19","doi-asserted-by":"publisher","DOI":"10.1002\/art.11073"},{"key":"2024102023545989000_47.5.1535.20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq321"},{"key":"2024102023545989000_47.5.1535.21","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0177-y"},{"key":"2024102023545989000_47.5.1535.22","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.12.1275"},{"key":"2024102023545989000_47.5.1535.23","first-page":"247","article-title":"The epidemiology of Sj\u00f6gren's syndrome","volume":"6","author":"Patel","year":"2014","journal-title":"Clin Epidemiol"},{"key":"2024102023545989000_47.5.1535.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.05.008"},{"key":"2024102023545989000_47.5.1535.25","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678847353"},{"key":"2024102023545989000_47.5.1535.26","doi-asserted-by":"publisher","DOI":"10.1002\/art.20093"},{"key":"2024102023545989000_47.5.1535.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.05.001"},{"key":"2024102023545989000_47.5.1535.28","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"2024102023545989000_47.5.1535.29","unstructured":"Gladman D , Urowitz M . Clinical features of systemic lupus erythematosus. In : Hochberg M , Silman A , Smolen J , et al. eds. Practical Rheumatology. Philadelphia, Mosby, 2004; pp. 417\u2013437."},{"key":"2024102023545989000_47.5.1535.30","doi-asserted-by":"publisher","DOI":"10.2165\/11598550-000000000-00000"},{"key":"2024102023545989000_47.5.1535.31","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000147737.57861.7c"},{"key":"2024102023545989000_47.5.1535.32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"2024102023545989000_47.5.1535.33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"2024102023545989000_47.5.1535.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14368-1"},{"key":"2024102023545989000_47.5.1535.35","doi-asserted-by":"crossref","unstructured":"Olson AL , Brown KK . Connective tissue disease-associated lung disorders. In: du Bois RM , Richeldi L , eds. Interstitial Lung Diseases (ERS Monograph). Sheffield, European Respiratory Society, 2009; pp. 225\u2013250.","DOI":"10.1183\/1025448x.00046012"},{"key":"2024102023545989000_47.5.1535.36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094128"},{"key":"2024102023545989000_47.5.1535.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2003.12.002"},{"key":"2024102023545989000_47.5.1535.38","first-page":"241","article-title":"Features of polymyositis and dermatomyositis in the elderly: a case-control study","volume":"18","author":"Pautas","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"2024102023545989000_47.5.1535.39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaut.2014.01.008","article-title":"The diagnosis and classification of mixed connective tissue disease","volume":"48-49","author":"Tani","year":"2014","journal-title":"J Autoimmun"},{"key":"2024102023545989000_47.5.1535.40","first-page":"265","article-title":"Antibodies against distinct nuclear matrix proteins are characteristic for mixed connective tissue disease","volume":"54","author":"Habets","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"2024102023545989000_47.5.1535.41","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143792"},{"key":"2024102023545989000_47.5.1535.42","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522060-00001"},{"key":"2024102023545989000_47.5.1535.43","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70036-3"},{"key":"2024102023545989000_47.5.1535.44","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780351211"},{"key":"2024102023545989000_47.5.1535.45","first-page":"1214","article-title":"Late onset peripheral spondylarthropathy","volume":"16","author":"Dubost","year":"1989","journal-title":"J Rheumatol"},{"key":"2024102023545989000_47.5.1535.46","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.3.176"},{"key":"2024102023545989000_47.5.1535.47","first-page":"899","article-title":"Late onset seronegative spondylarthropathy","volume":"22","author":"Olivieri","year":"1995","journal-title":"J Rheumatol"},{"key":"2024102023545989000_47.5.1535.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.03.004"},{"key":"2024102023545989000_47.5.1535.49","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300125"},{"key":"2024102023545989000_47.5.1535.50","first-page":"313","article-title":"Five-year follow-up of 665 Hungarian patients with undifferentiated connective tissue disease (UCTD","volume":"21","author":"Bodolay","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"2024102023545989000_47.5.1535.51","first-page":"2345","article-title":"Undifferentiated connective tissue disease: analysis of 83 patients with a minimum follow-up of 5\u2005years","volume":"29","author":"Mosca","year":"2002","journal-title":"J Rheumatol"},{"key":"2024102023545989000_47.5.1535.52","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1175-2"},{"key":"2024102023545989000_47.5.1535.53","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2662"},{"key":"2024102023545989000_47.5.1535.54","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00174910"},{"key":"2024102023545989000_47.5.1535.55","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0194"},{"key":"2024102023545989000_47.5.1535.56","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00150-2015"},{"key":"2024102023545989000_47.5.1535.57","doi-asserted-by":"publisher","DOI":"10.1002\/art.10561"},{"key":"2024102023545989000_47.5.1535.58","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000153572.22346.E9"},{"key":"2024102023545989000_47.5.1535.59","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg184"},{"key":"2024102023545989000_47.5.1535.60","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00023-5"},{"key":"2024102023545989000_47.5.1535.61","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0059-3"},{"key":"2024102023545989000_47.5.1535.62","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200008)43:8<1831::AID-ANR19>3.0.CO;2-6"},{"key":"2024102023545989000_47.5.1535.63","first-page":"231","article-title":"Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis","volume":"32","author":"Raza","year":"2005","journal-title":"J Rheumatol"},{"key":"2024102023545989000_47.5.1535.64","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2042ST"},{"key":"2024102023545989000_47.5.1535.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2014.12.003"},{"key":"2024102023545989000_47.5.1535.66","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.59"},{"key":"2024102023545989000_47.5.1535.67","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20922"},{"key":"2024102023545989000_47.5.1535.68","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"2024102023545989000_47.5.1535.69","first-page":"S53","article-title":"Six-minute walk distance as a marker for disability and complaints in patients with systemic sclerosis","volume":"29","author":"Deuschle","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"2024102023545989000_47.5.1535.70","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21583"},{"key":"2024102023545989000_47.5.1535.71","first-page":"81","article-title":"Relationship between cutaneous and pulmonary involvement in systemic sclerosis","volume":"24","author":"Morelli","year":"1997","journal-title":"J Rheumatol"},{"key":"2024102023545989000_47.5.1535.72","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.1.2928513"},{"key":"2024102023545989000_47.5.1535.73","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130187"},{"key":"2024102023545989000_47.5.1535.74","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092309"},{"key":"2024102023545989000_47.5.1535.75","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991525"},{"key":"2024102023545989000_47.5.1535.76","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991524"},{"key":"2024102023545989000_47.5.1535.77","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200806-953OC"},{"key":"2024102023545989000_47.5.1535.78","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"2024102023545989000_47.5.1535.79","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"2024102023545989000_47.5.1535.80","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1356547"},{"key":"2024102023545989000_47.5.1535.81","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh067"},{"key":"2024102023545989000_47.5.1535.82","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203301"},{"key":"2024102023545989000_47.5.1535.83","doi-asserted-by":"publisher","DOI":"10.1002\/art.10775"},{"key":"2024102023545989000_47.5.1535.84","doi-asserted-by":"publisher","DOI":"10.1002\/art.21433"},{"key":"2024102023545989000_47.5.1535.85","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi891"},{"key":"2024102023545989000_47.5.1535.86","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0622OC"},{"key":"2024102023545989000_47.5.1535.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2012.09.002"},{"key":"2024102023545989000_47.5.1535.88","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-007-0004-1"},{"key":"2024102023545989000_47.5.1535.89","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70047-5"},{"key":"2024102023545989000_47.5.1535.90","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.2019"},{"key":"2024102023545989000_47.5.1535.91","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985609"},{"key":"2024102023545989000_47.5.1535.92","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00021005"},{"key":"2024102023545989000_47.5.1535.93","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2306"},{"key":"2024102023545989000_47.5.1535.94","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00038709"},{"key":"2024102023545989000_47.5.1535.95","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2111053"},{"key":"2024102023545989000_47.5.1535.96","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0538"},{"key":"2024102023545989000_47.5.1535.97","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.8.622"},{"key":"2024102023545989000_47.5.1535.98","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2321030174"},{"key":"2024102023545989000_47.5.1535.99","doi-asserted-by":"publisher","DOI":"10.1002\/art.30077"},{"key":"2024102023545989000_47.5.1535.100","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200203000-00004"},{"key":"2024102023545989000_47.5.1535.101","doi-asserted-by":"publisher","DOI":"10.1002\/art.22532"},{"key":"2024102023545989000_47.5.1535.102","first-page":"2230","article-title":"Pulmonary arterial hypertension and severe pulmonary fibrosis in systemic sclerosis patients with a nucleolar antibody","volume":"34","author":"Steen","year":"2007","journal-title":"J Rheumatol"},{"key":"2024102023545989000_47.5.1535.103","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310207"},{"key":"2024102023545989000_47.5.1535.104","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106012"},{"key":"2024102023545989000_47.5.1535.105","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2444"},{"key":"2024102023545989000_47.5.1535.106","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101365"},{"key":"2024102023545989000_47.5.1535.107","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2322031223"},{"key":"2024102023545989000_47.5.1535.108","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2626"},{"key":"2024102023545989000_47.5.1535.109","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1088"},{"key":"2024102023545989000_47.5.1535.110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"2024102023545989000_47.5.1535.111","doi-asserted-by":"crossref","unstructured":"Crestani B , Debray M-P , Danel C , et al. Interstitial lung disease in connective tissue diseases other than systemic sclerosis. In : Cottin B , Cordier J-F , Richeldi L , eds. Orphan lung diseases. London, Springer, 2015; pp. 391\u2013418.","DOI":"10.1007\/978-1-4471-2401-6_26"},{"key":"2024102023545989000_47.5.1535.112","first-page":"349","article-title":"A longitudinal study of lung impairment in patients with primary Sjogren's syndrome","volume":"15","author":"Mialon","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"2024102023545989000_47.5.1535.113","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318181e6af"},{"key":"2024102023545989000_47.5.1535.114","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.5.1489"},{"key":"2024102023545989000_47.5.1535.115","doi-asserted-by":"publisher","DOI":"10.1007\/s13665-012-0028-7"},{"key":"2024102023545989000_47.5.1535.116","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1371537"},{"key":"2024102023545989000_47.5.1535.117","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200009000-00007"},{"key":"2024102023545989000_47.5.1535.118","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780321007"},{"key":"2024102023545989000_47.5.1535.119","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70105-2"},{"key":"2024102023545989000_47.5.1535.120","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu170oa"},{"key":"2024102023545989000_47.5.1535.121","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199705000-00005"},{"key":"2024102023545989000_47.5.1535.122","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0079"},{"key":"2024102023545989000_47.5.1535.123","doi-asserted-by":"publisher","DOI":"10.1007\/s002960050074"},{"key":"2024102023545989000_47.5.1535.124","doi-asserted-by":"publisher","DOI":"10.1002\/art.30541"},{"key":"2024102023545989000_47.5.1535.125","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"2024102023545989000_47.5.1535.126","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.05.001"},{"key":"2024102023545989000_47.5.1535.127","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985666"},{"key":"2024102023545989000_47.5.1535.128","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.50012"},{"key":"2024102023545989000_47.5.1535.129","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(96)80026-6"},{"key":"2024102023545989000_47.5.1535.130","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090652"},{"key":"2024102023545989000_47.5.1535.131","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.4.1096"},{"key":"2024102023545989000_47.5.1535.132","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2012.01.004"},{"key":"2024102023545989000_47.5.1535.133","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198403000-00003"},{"key":"2024102023545989000_47.5.1535.134","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70113-1"},{"key":"2024102023545989000_47.5.1535.135","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.05.004"},{"key":"2024102023545989000_47.5.1535.136","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201253"},{"key":"2024102023545989000_47.5.1535.137","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.05.002"},{"key":"2024102023545989000_47.5.1535.138","first-page":"641","article-title":"Pleuropulmonary manifestations of ankylosing spondylitis","volume":"52","author":"Rosenow","year":"1977","journal-title":"Mayo Clin Proc"},{"key":"2024102023545989000_47.5.1535.139","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000239551.47702.f4"},{"key":"2024102023545989000_47.5.1535.140","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.2.183"},{"key":"2024102023545989000_47.5.1535.141","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.18.6622"},{"key":"2024102023545989000_47.5.1535.142","doi-asserted-by":"publisher","DOI":"10.1126\/science.7544491"},{"key":"2024102023545989000_47.5.1535.143","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90170-9"},{"key":"2024102023545989000_47.5.1535.144","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00229714"},{"key":"2024102023545989000_47.5.1535.145","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66370"},{"key":"2024102023545989000_47.5.1535.146","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.04.004"},{"key":"2024102023545989000_47.5.1535.147","doi-asserted-by":"publisher","DOI":"10.1002\/art.23287"},{"key":"2024102023545989000_47.5.1535.148","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.059188"},{"key":"2024102023545989000_47.5.1535.149","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00583.x"},{"key":"2024102023545989000_47.5.1535.150","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206084"},{"key":"2024102023545989000_47.5.1535.151","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00087005"},{"key":"2024102023545989000_47.5.1535.152","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66630-5"},{"key":"2024102023545989000_47.5.1535.153","doi-asserted-by":"publisher","DOI":"10.1159\/000089870"},{"key":"2024102023545989000_47.5.1535.154","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066157"},{"key":"2024102023545989000_47.5.1535.155","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804280105"},{"key":"2024102023545989000_47.5.1535.156","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1104OC"},{"key":"2024102023545989000_47.5.1535.157","doi-asserted-by":"publisher","DOI":"10.1002\/art.21575"},{"key":"2024102023545989000_47.5.1535.158","doi-asserted-by":"publisher","DOI":"10.1002\/art.11223"},{"key":"2024102023545989000_47.5.1535.159","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00027913"},{"key":"2024102023545989000_47.5.1535.160","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0444"},{"key":"2024102023545989000_47.5.1535.161","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092309"},{"key":"2024102023545989000_47.5.1535.162","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.039438"},{"key":"2024102023545989000_47.5.1535.163","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046052"},{"key":"2024102023545989000_47.5.1535.164","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200603-054MS"},{"key":"2024102023545989000_47.5.1535.165","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.035"},{"key":"2024102023545989000_47.5.1535.166","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.031"},{"key":"2024102023545989000_47.5.1535.167","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2037OC"},{"key":"2024102023545989000_47.5.1535.168","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001352"},{"key":"2024102023545989000_47.5.1535.169","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055120"},{"key":"2024102023545989000_47.5.1535.170","doi-asserted-by":"publisher","DOI":"10.1002\/art.22204"},{"key":"2024102023545989000_47.5.1535.171","doi-asserted-by":"publisher","DOI":"10.1002\/art.10524"},{"key":"2024102023545989000_47.5.1535.172","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.19.2275"},{"key":"2024102023545989000_47.5.1535.173","doi-asserted-by":"publisher","DOI":"10.1002\/art.21978"},{"key":"2024102023545989000_47.5.1535.174","doi-asserted-by":"publisher","DOI":"10.1002\/art.10529"},{"key":"2024102023545989000_47.5.1535.175","doi-asserted-by":"publisher","DOI":"10.1002\/art.21568"},{"key":"2024102023545989000_47.5.1535.176","doi-asserted-by":"publisher","DOI":"10.1002\/art.22504"},{"key":"2024102023545989000_47.5.1535.177","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.048967"},{"key":"2024102023545989000_47.5.1535.178","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.033"},{"key":"2024102023545989000_47.5.1535.179","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213917"},{"key":"2024102023545989000_47.5.1535.180","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340504"},{"key":"2024102023545989000_47.5.1535.181","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7326\/0003-4819-132-6-200003210-00002","article-title":"Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial","volume":"132","author":"Badesch","year":"2000","journal-title":"Ann Intern Med"},{"key":"2024102023545989000_47.5.1535.182","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.2.420"},{"key":"2024102023545989000_47.5.1535.183","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(15)61538-8"},{"key":"2024102023545989000_47.5.1535.184","first-page":"2417","article-title":"Sildenafil for pulmonary arterial hypertension associated with connective tissue disease","volume":"34","author":"Badesch","year":"2007","journal-title":"J Rheumatol"},{"key":"2024102023545989000_47.5.1535.185","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.839274"},{"key":"2024102023545989000_47.5.1535.186","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/annrheumdis-2015-eular.4461","article-title":"Efficacy and safety of riociguat in patients with pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD): results from Patent-1 and Patent-2","volume":"74","author":"Denton","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"2024102023545989000_47.5.1535.187","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1331PP"},{"key":"2024102023545989000_47.5.1535.188","doi-asserted-by":"publisher","DOI":"10.1002\/art.24267"},{"key":"2024102023545989000_47.5.1535.189","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100632"},{"key":"2024102023545989000_47.5.1535.190","doi-asserted-by":"publisher","DOI":"10.1002\/art.23811"},{"key":"2024102023545989000_47.5.1535.191","doi-asserted-by":"publisher","DOI":"10.1002\/art.20878"},{"key":"2024102023545989000_47.5.1535.192","doi-asserted-by":"crossref","first-page":"809514","DOI":"10.1155\/2015\/809514","article-title":"Increased incidence of atrial fibrillation in patients with rheumatoid arthritis","volume":"2015","author":"Bacani","year":"2015","journal-title":"Biomed Res Int"},{"key":"2024102023545989000_47.5.1535.193","doi-asserted-by":"publisher","DOI":"10.1002\/art.20855"},{"key":"2024102023545989000_47.5.1535.194","doi-asserted-by":"publisher","DOI":"10.1186\/ar2404"},{"key":"2024102023545989000_47.5.1535.195","doi-asserted-by":"publisher","DOI":"10.1002\/art.23913"},{"key":"2024102023545989000_47.5.1535.196","doi-asserted-by":"publisher","DOI":"10.1002\/art.22600"},{"key":"2024102023545989000_47.5.1535.197","doi-asserted-by":"publisher","DOI":"10.1002\/art.22117"},{"key":"2024102023545989000_47.5.1535.198","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jbmr.5650100212","article-title":"Rheumatoid arthritis and bone mineral density in elderly women. The Study of Osteoporotic Fractures Research Group","volume":"10","author":"Lane","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2024102023545989000_47.5.1535.199","doi-asserted-by":"publisher","DOI":"10.1002\/art.30277"},{"key":"2024102023545989000_47.5.1535.200","first-page":"47","article-title":"The costs of rheumatoid arthritis: absolute, incremental, and marginal estimates","volume":"44","author":"Yelin","year":"1996","journal-title":"J Rheumatol Suppl"},{"key":"2024102023545989000_47.5.1535.201","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X104641"},{"key":"2024102023545989000_47.5.1535.202","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X280617"},{"key":"2024102023545989000_47.5.1535.203","doi-asserted-by":"publisher","DOI":"10.1002\/art.37969"},{"key":"2024102023545989000_47.5.1535.204","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2010.02281.x"},{"key":"2024102023545989000_47.5.1535.205","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090942"},{"key":"2024102023545989000_47.5.1535.206","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203305"},{"key":"2024102023545989000_47.5.1535.207","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(94)90055-8"},{"key":"2024102023545989000_47.5.1535.208","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000209423.39033.94"},{"key":"2024102023545989000_47.5.1535.209","first-page":"S66","article-title":"Mortality in Sj\u00f6gren's syndrome","volume":"26: Suppl. 51","author":"Voulgarelis","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"2024102023545989000_47.5.1535.210","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60279-7"},{"key":"2024102023545989000_47.5.1535.211","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2013.856005"},{"key":"2024102023545989000_47.5.1535.212","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101132"},{"key":"2024102023545989000_47.5.1535.213","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199901)42:1<51::AID-ANR7>3.0.CO;2-D"},{"key":"2024102023545989000_47.5.1535.214","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500285352"},{"key":"2024102023545989000_47.5.1535.215","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834ff258"},{"key":"2024102023545989000_47.5.1535.216","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000091181.93122.55"},{"key":"2024102023545989000_47.5.1535.217","doi-asserted-by":"publisher","DOI":"10.1002\/art.21765"},{"key":"2024102023545989000_47.5.1535.218","doi-asserted-by":"publisher","DOI":"10.1002\/art.33379"},{"key":"2024102023545989000_47.5.1535.219","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2010.01470.x"},{"key":"2024102023545989000_47.5.1535.220","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.06.021"},{"key":"2024102023545989000_47.5.1535.221","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-1164-z"},{"key":"2024102023545989000_47.5.1535.222","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121272"},{"key":"2024102023545989000_47.5.1535.223","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<899::AID-ANR8>3.0.CO;2-L"},{"key":"2024102023545989000_47.5.1535.224","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.04.005"},{"key":"2024102023545989000_47.5.1535.225","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.116178"},{"key":"2024102023545989000_47.5.1535.226","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.3.174"},{"key":"2024102023545989000_47.5.1535.227","first-page":"S16","article-title":"Mortality, course of disease and prognosis of patients with ankylosing spondylitis","volume":"20: Suppl. 28","author":"Braun","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"2024102023545989000_47.5.1535.228","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(94)90087-6"},{"key":"2024102023545989000_47.5.1535.229","doi-asserted-by":"crossref","first-page":"40S","DOI":"10.1016\/S0002-9343(97)90007-3","article-title":"Rheumatoid arthritis in the elderly: is it a different disease?","volume":"103","author":"Kavanaugh","year":"1997","journal-title":"Am J Med"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00829-2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:31:32Z","timestamp":1740360692000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00829-2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":229,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,4,30]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1183\/13993003.00829-2015"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00829-2015","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,25]]}}}