{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:45:00Z","timestamp":1790703900744,"version":"4.1.0"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,10,17]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>The aim of this study was to compare radiology-based prediction models in rheumatoid arthritis-related interstitial lung disease (RAILD) to identify patients with a progressive fibrosis phenotype.<\/jats:p>\n                  <jats:p>RAILD patients had computed tomography (CT) scans scored visually and using CALIPER and forced\u00a0vital capacity (FVC) measurements. Outcomes were evaluated using three techniques, as follows. 1)\u00a0Scleroderma system evaluating visual interstitial lung disease extent and FVC values; 2) Fleischner Society idiopathic pulmonary fibrosis (IPF) diagnostic guidelines applied to RAILD; and 3) CALIPER scores of vessel-related structures (VRS). Outcomes were compared to IPF patients.<\/jats:p>\n                  <jats:p>\n                    On univariable Cox analysis, all three staging systems strongly predicted outcome (scleroderma system hazard ratio (HR) 3.78, p=9\u00d710\n                    <jats:sup>\u22125<\/jats:sup>\n                    ; Fleischner system HR 1.98, p=2\u00d710\n                    <jats:sup>\u22123<\/jats:sup>\n                    ; and 4.4% VRS threshold HR 3.10, p=4\u00d710\n                    <jats:sup>\u22124<\/jats:sup>\n                    ). When the scleroderma and Fleischner systems were combined, termed the progressive fibrotic system (C-statistic 0.71), they identified a patient subset (n=36) with a progressive fibrotic phenotype and similar 4-year survival to IPF. On multivariable analysis, with adjustment for patient age, sex and smoking status, when analysed alongside the progressive fibrotic system, the VRS threshold of 4.4% independently predicted outcome (model C-statistic 0.77).\n                  <\/jats:p>\n                  <jats:p>The combination of two visual CT-based staging systems identified 23% of an RAILD cohort with an IPF-like progressive fibrotic phenotype. The addition of a computer-derived VRS threshold further improved outcome prediction and model fit, beyond that encompassed by RAILD measures of disease severity and extent.<\/jats:p>","DOI":"10.1183\/13993003.00869-2018","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:25:13Z","timestamp":1543451113000},"page":"1800869","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":159,"title":["Predicting outcomes in rheumatoid arthritis related interstitial lung disease"],"prefix":"10.1183","volume":"53","author":[{"given":"Joseph","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Hirani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coline H.M.","family":"van Moorsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Rajagopalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Murchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik W.","family":"van Es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian\u00a0J.","family":"Bartholmai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frouke T.","family":"van Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn H.L.","family":"Struik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth A.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kokosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Egashira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Laure","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Devaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Margaritopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Karwoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Renzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby M.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athol\u00a0U.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"2024102100410008000_53.1.1800869.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211138"},{"key":"2024102100410008000_53.1.1800869.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27405"},{"key":"2024102100410008000_53.1.1800869.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"2024102100410008000_53.1.1800869.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092309"},{"key":"2024102100410008000_53.1.1800869.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.05.002"},{"key":"2024102100410008000_53.1.1800869.6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00357-2015"},{"key":"2024102100410008000_53.1.1800869.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.2019"},{"key":"2024102100410008000_53.1.1800869.8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.rmed.2017.03.027","article-title":"High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: relationship to survival","volume":"126","author":"Yunt","year":"2017","journal-title":"Respir Med"},{"key":"2024102100410008000_53.1.1800869.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu165"},{"key":"2024102100410008000_53.1.1800869.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00019210"},{"key":"2024102100410008000_53.1.1800869.11","doi-asserted-by":"crossref","unstructured":"Yang JA , Lee JS , Park JK , et\u00a0al. Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis. Korean J Intern Med 2017; in press [ https:\/\/doi.org\/10.3904\/kjim.2016.349].","DOI":"10.3904\/kjim.2016.349"},{"key":"2024102100410008000_53.1.1800869.12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.9.1022"},{"key":"2024102100410008000_53.1.1800869.13","first-page":"280","article-title":"Rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis: shared mechanistic and phenotypic traits suggest overlapping disease mechanisms","volume":"67","author":"Paulin","year":"2015","journal-title":"Rev Invest Clin"},{"key":"2024102100410008000_53.1.1800869.14","doi-asserted-by":"crossref","first-page":"L998","DOI":"10.1152\/ajplung.00304.2017","article-title":"Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease","volume":"314","author":"Redente","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2024102100410008000_53.1.1800869.15","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00692-2018"},{"key":"2024102100410008000_53.1.1800869.16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200706-877OC"},{"key":"2024102100410008000_53.1.1800869.17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S2213-2600(17)30433-2","article-title":"Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society white paper","volume":"6","author":"Lynch","year":"2018","journal-title":"Lancet Respir Med"},{"key":"2024102100410008000_53.1.1800869.18","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"2024102100410008000_53.1.1800869.19","first-page":"642","article-title":"Cigarette smoking among adults \u2013 United States, 2000","volume":"51","author":"Centers for Disease Control and Prevention","year":"2002","journal-title":"MMMWR Morb Mortal Wkly Rep"},{"key":"2024102100410008000_53.1.1800869.20","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00379-2017"},{"key":"2024102100410008000_53.1.1800869.21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01011-2016"},{"key":"2024102100410008000_53.1.1800869.22","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"2024102100410008000_53.1.1800869.23","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1164\/rccm.201711-2174OC","article-title":"Predicting outcome in idiopathic pulmonary fibrosis using automated CT analysis","volume":"198","author":"Jacob","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102100410008000_53.1.1800869.24","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2408"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00869-2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T02:31:09Z","timestamp":1740364269000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00869-2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,3]]},"published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1183\/13993003.00869-2018"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00869-2018","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]}}}