{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:18:33Z","timestamp":1790432313118,"version":"4.1.0"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"6","funder":[{"DOI":"10.13039\/501100005026","name":"Stichting Tegen Kanker","doi-asserted-by":"publisher","award":["STK2010-205"],"award-info":[{"award-number":["STK2010-205"]}],"id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005026","name":"Stichting Tegen Kanker","doi-asserted-by":"publisher","award":["STK2012-223"],"award-info":[{"award-number":["STK2012-223"]}],"id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Flemish League Against Cancer","award":["Grant \u2018Emmanuel van der Schueren\u2019"],"award-info":[{"award-number":["Grant \u2018Emmanuel van der Schueren\u2019"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,9,24]]},"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Malignant pleural mesothelioma (MPM) is predominantly caused by asbestos exposure and has a poor prognosis. Breath contains volatile organic compounds (VOCs) and can be explored as an early detection tool. Previously, we used multicapillary column\/ion mobility spectrometry (MCC\/IMS) to discriminate between patients with MPM and asymptomatic high-risk persons with a high rate of accuracy. Here, we aim to validate these findings in different control groups.<\/jats:p><jats:p>Breath and background samples were obtained from 52 patients with MPM, 52 healthy controls without asbestos exposure (HC), 59 asymptomatic former asbestos workers (AEx), 41 patients with benign asbestos-related diseases (ARD), 70 patients with benign non-asbestos-related lung diseases (BLD) and 56 patients with lung cancer (LC).<\/jats:p><jats:p>After background correction, logistic lasso regression and receiver operating characteristic (ROC) analysis, the MPM group was discriminated from the HC, AEx, ARD, BLD and LC groups with 65%, 88%, 82%, 80% and 72% accuracy, respectively. Combining AEx and ARD patients resulted in 94% sensitivity and 96% negative predictive value (NPV). The most important VOCs selected were P1, P3, P7, P9, P21 and P26.<\/jats:p><jats:p>We discriminated MPM patients from at-risk subjects with great accuracy. The high sensitivity and NPV allow breath analysis to be used as a screening tool for ruling out MPM.<\/jats:p>","DOI":"10.1183\/13993003.00919-2017","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T01:10:35Z","timestamp":1513905035000},"page":"1700919","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Exhaled breath to screen for malignant pleural mesothelioma: a validation study"],"prefix":"10.1183","volume":"50","author":[{"given":"Kevin","family":"Lamote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs","family":"Vynck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Thas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Van Cleemput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiaan","family":"Nackaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P.","family":"van Meerbeeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"2024101904344338000_50.6.1700919.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690105"},{"key":"2024101904344338000_50.6.1700919.2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jare.2014.11.012","article-title":"Mesothelioma treatment: are we on target? 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