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In our global study, we describe long-term outcomes of patients affected by TB and COVID-19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19<jats:italic>versus<\/jats:italic>those dying because of either TB or COVID-19 alone (p&lt;0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03\u20131.07), HIV infection (HR 2.29, 95% CI 1.02\u20135.16) and invasive ventilation (HR 4.28, 95% CI 2.34\u20137.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02\u20131.04), male sex (HR 2.21, 95% CI 1.24\u20133.91), oxygen requirement (HR 7.93, 95% CI 3.44\u201318.26) and invasive ventilation (HR 2.19, 95% CI 1.36\u20133.53).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our global cohort, death was the outcome in &gt;10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.00925-2023","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T16:20:42Z","timestamp":1697127642000},"page":"2300925","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort"],"prefix":"10.1183","volume":"62","author":[{"name":"Global Tuberculosis Network and TB\/COVID-19 Global Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Casco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Levi","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo 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