{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:22:05Z","timestamp":1790767325337,"version":"4.1.0"},"reference-count":0,"publisher":"European Respiratory Society (ERS)","funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_197706"],"award-info":[{"award-number":["32003B_197706"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ersjournals.com"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2024,1,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of a daylong exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension (PAH\/CTEPH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomised controlled cross-over trial, stable patients with PAH or distal CTEPH without resting hypoxemia at low altitude performed two incremental exercise tests to exhaustion, one after 3\u20135\u2005h at high (2500\u2005m) and one at low altitude (470\u2005m).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 27 patients with PAH\/CTEPH (44% women, 61\u00b114\u2005y), maximal work-rate was 110\u00b164 watts at 2500\u2005m and 123\u00b164 watts at 470\u2005m (\u221211%, 95%CI: \u221216 to \u221211, p&lt;0.001). SpO<jats:sub>2<\/jats:sub>and PaO<jats:sub>2<\/jats:sub>at end-exercise were 83\u00b16%<jats:italic>versus<\/jats:italic>91\u00b16% and 6.1\u00b11.9\u2005kPa<jats:italic>versus<\/jats:italic>8.6\u00b11.9\u2005kPa (\u22128%; \u221229%; both p&lt;0.001) at 2500\u2005m<jats:italic>versus<\/jats:italic>470\u2005m, respectively. Maximal oxygen uptake at high altitude was 17.8\u00b17.5\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7kg<jats:sup>\u22121<\/jats:sup><jats:italic>versus<\/jats:italic>20\u00b17.4\u2005L\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7kg<jats:sup>\u22121<\/jats:sup>at low altitude (\u221211%, p&lt;0.001). At end-exercise, the ventilatory equivalent for CO<jats:sub>2<\/jats:sub>was 43\u00b19 at 2500\u2005m<jats:italic>versus<\/jats:italic>39\u00b19 at 470\u2005m (+9%, 95%CI: 2 to 6; p=0.002). No adverse events occurred during or after exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among predominantly low-risk patients with stable PAH\/CTEPH, cycling exercise during the first day at 2500\u2005m was well tolerated, but peak exercise capacity, blood oxygenation and ventilatory efficiency were lower compared to 470\u2005m.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.01001-2023","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T16:45:13Z","timestamp":1709225113000},"page":"2301001","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The effect of high altitude (2500\u2005m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled cross-over trial"],"prefix":"10.1183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-5937","authenticated-orcid":false,"given":"Julian","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7431-1643","authenticated-orcid":false,"given":"Anna","family":"Titz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3635-0515","authenticated-orcid":false,"given":"Simon R.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meret","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"L\u00fc\u00f6nd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-5029","authenticated-orcid":false,"given":"Michael","family":"Furian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aglaia","family":"Forrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther I.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad E.","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4485-1758","authenticated-orcid":false,"given":"Mona","family":"Lichtblau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-5022","authenticated-orcid":false,"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2024,2,29]]},"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01001-2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:18:04Z","timestamp":1740381484000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01001-2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":0,"alternative-id":["10.1183\/13993003.01001-2023"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01001-2023","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,29]]}}}