{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:42:21Z","timestamp":1789879341488,"version":"4.0.1"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,7,20]]},"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Screening is important to determine whether patients with systemic sclerosis (SSc) have pulmonary hypertension because earlier pulmonary hypertension treatment can improve survival in these patients. Although decreased transfer factor of the lung for carbon monoxide (<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>) is currently considered the best pulmonary function test for screening for pulmonary hypertension in SSc, small series have suggested that partitioning<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>into membrane conductance (diffusing capacity) for carbon monoxide (<jats:italic>D<\/jats:italic><jats:sub>MCO<\/jats:sub>) and alveolar capillary blood volume (<jats:italic>V<\/jats:italic><jats:sub>C<\/jats:sub>) through combined measurement of<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>and transfer factor of the lung for nitric oxide (<jats:italic>T<\/jats:italic><jats:sub>LNO<\/jats:sub>) is more effective to identify pulmonary hypertension in SSc patients compared with<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>alone. Here, the objective was to determine whether combined<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>\u2013<jats:italic>T<\/jats:italic><jats:sub>LNO<\/jats:sub>partitioned with recently refined equations could more accurately detect pulmonary hypertension than<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>alone in SSc.<\/jats:p><jats:p>For that purpose, 572 unselected consecutive SSc patients were retrospectively recruited in seven French centres.<\/jats:p><jats:p>Pulmonary hypertension was diagnosed with right heart catheterisation in 58 patients.<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>,<jats:italic>T<\/jats:italic><jats:sub>LNO<\/jats:sub>and<jats:italic>V<\/jats:italic><jats:sub>C<\/jats:sub>were all lower in SSc patients with pulmonary hypertension than in SSc patients without pulmonary hypertension. The area under the receiver operating characteristic curve for the presence of pulmonary hypertension was equivalent for<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>(0.82, 95% CI 0.79\u20130.85) and<jats:italic>T<\/jats:italic><jats:sub>LNO<\/jats:sub>(0.80, 95% CI 0.76\u20130.83), but lower for<jats:italic>V<\/jats:italic><jats:sub>C<\/jats:sub>(0.75, 95% CI 0.71\u20130.78) and<jats:italic>D<\/jats:italic><jats:sub>MCO<\/jats:sub>(0.66, 95% CI 0.62\u20130.70).<\/jats:p><jats:p>Compared with<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>alone, combined<jats:italic>T<\/jats:italic><jats:sub>LCO<\/jats:sub>\u2013<jats:italic>T<\/jats:italic><jats:sub>LNO<\/jats:sub>does not add capability to detect pulmonary hypertension in unselected SSc patients.<\/jats:p>","DOI":"10.1183\/13993003.01008-2017","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T10:38:48Z","timestamp":1508495928000},"page":"1701008","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Combined measurement of carbon monoxide and nitric oxide lung transfer does not improve the identification of pulmonary hypertension in systemic sclerosis"],"prefix":"10.1183","volume":"50","author":[{"given":"Bruno","family":"Degano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Soumagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Delaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Guillien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Pellegrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Launay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Magy-Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Agard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiet Phong","family":"Tiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00f4ng","family":"Hua-Huy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Tardiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Chambellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Tuan","family":"Dinh-Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"2024101904281048000_50.4.1701008.1","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/j.lpm.2014.08.001","article-title":"Pathophysiology of systemic sclerosis: state of the art in 2014","volume":"43","author":"Dumoitier","year":"2014","journal-title":"Presse Med"},{"key":"2024101904281048000_50.4.1701008.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"key":"2024101904281048000_50.4.1701008.3","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005512"},{"key":"2024101904281048000_50.4.1701008.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200706-877OC"},{"key":"2024101904281048000_50.4.1701008.5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.6.8004317"},{"key":"2024101904281048000_50.4.1701008.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106012"},{"key":"2024101904281048000_50.4.1701008.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.30541"},{"key":"2024101904281048000_50.4.1701008.8","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/art.38623","article-title":"Improved transplant-free survival in patients with systemic sclerosis-associated pulmonary hypertension and interstitial lung disease","volume":"66","author":"Volkmann","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2024101904281048000_50.4.1701008.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.38172"},{"key":"2024101904281048000_50.4.1701008.10","doi-asserted-by":"publisher","DOI":"10.1002\/art.10775"},{"key":"2024101904281048000_50.4.1701008.11","doi-asserted-by":"publisher","DOI":"10.1002\/art.21433"},{"key":"2024101904281048000_50.4.1701008.12","doi-asserted-by":"publisher","DOI":"10.1159\/000335473"},{"key":"2024101904281048000_50.4.1701008.13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1152\/jappl.1957.11.2.290","article-title":"Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries","volume":"11","author":"Roughton","year":"1957","journal-title":"J Appl Physiol"},{"key":"2024101904281048000_50.4.1701008.14","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91621.2008"},{"key":"2024101904281048000_50.4.1701008.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(87)80036-1"},{"key":"2024101904281048000_50.4.1701008.16","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00962-2016"},{"key":"2024101904281048000_50.4.1701008.17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resp.2017.03.008","article-title":"Nitric oxide uptake in the lung: it is about time that clinicians use this test routinely","volume":"241","author":"Zavorsky","year":"2017","journal-title":"Respir Physiol Neurobiol"},{"key":"2024101904281048000_50.4.1701008.18","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-68"},{"key":"2024101904281048000_50.4.1701008.19","first-page":"S80","article-title":"Determinants of impairment in lung diffusing capacity in patients with systemic sclerosis","volume":"33","author":"Guarnieri","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"2024101904281048000_50.4.1701008.20","doi-asserted-by":"crossref","first-page":"e78001","DOI":"10.1371\/journal.pone.0078001","article-title":"Relevance of partitioning DLCO to detect pulmonary hypertension in systemic sclerosis","volume":"8","author":"Sivova","year":"2013","journal-title":"PLoS One"},{"key":"2024101904281048000_50.4.1701008.21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/cpf.12316","article-title":"Nitrogen monoxide and carbon monoxide transfer interpretation: state of the art","volume":"37","author":"Martinot","year":"2017","journal-title":"Clin Physiol Funct Imaging"},{"key":"2024101904281048000_50.4.1701008.22","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"2024101904281048000_50.4.1701008.23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2024101904281048000_50.4.1701008.24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"2024101904281048000_50.4.1701008.25","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"2024101904281048000_50.4.1701008.26","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"2024101904281048000_50.4.1701008.27","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-4-394"},{"key":"2024101904281048000_50.4.1701008.28","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290409"},{"key":"2024101904281048000_50.4.1701008.29","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203301"},{"key":"2024101904281048000_50.4.1701008.30","doi-asserted-by":"publisher","DOI":"10.1002\/art.30535"},{"key":"2024101904281048000_50.4.1701008.31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.resp.2016.11.008","article-title":"Can the measurement of pulmonary diffusing capacity for nitric oxide replace the measurement of pulmonary diffusing capacity for carbon monoxide?","volume":"241","author":"Zavorsky","year":"2017","journal-title":"Respir Physiol Neurobiol"},{"key":"2024101904281048000_50.4.1701008.32","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199707)40:7<1229::AID-ART6>3.0.CO;2-W"},{"key":"2024101904281048000_50.4.1701008.33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.resp.2016.12.014","article-title":"The Roughton\u2013Forster equation for DLCO and DLNO re-examined","volume":"241","author":"Kang","year":"2017","journal-title":"Respir Physiol Neurobiol"},{"key":"2024101904281048000_50.4.1701008.34","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.healun.2015.12.022","article-title":"Lung capillary blood volume and membrane diffusion in precapillary pulmonary hypertension","volume":"35","author":"Godinas","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"2024101904281048000_50.4.1701008.35","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-6"},{"key":"2024101904281048000_50.4.1701008.36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.resp.2017.01.002","article-title":"The DLNO\/DLCO ratio: physiological significance and clinical implications","volume":"241","author":"Hughes","year":"2017","journal-title":"Respir Physiol Neurobiol"},{"key":"2024101904281048000_50.4.1701008.37","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00002915"},{"key":"2024101904281048000_50.4.1701008.38","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/art.38390","article-title":"Prediction of pulmonary complications and long-term survival in systemic sclerosis","volume":"66","author":"Nihtyanova","year":"2014","journal-title":"Arthritis Rheum"},{"key":"2024101904281048000_50.4.1701008.39","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100245"},{"key":"2024101904281048000_50.4.1701008.40","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12890-016-0296-z","article-title":"Risk factors for development of pulmonary arterial hypertension in Australian systemic sclerosis patients: results from a large multicenter cohort study","volume":"16","author":"Morrisroe","year":"2016","journal-title":"BMC Pulm Med"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01008-2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:44:56Z","timestamp":1740379496000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01008-2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,10,19]]},"published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1183\/13993003.01008-2017"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01008-2017","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}