{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:15:19Z","timestamp":1790950519111,"version":"4.1.0"},"reference-count":116,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,9,8]]},"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>New approaches to control the spread of tuberculosis (TB) are needed, including tools to predict development of active TB from latent TB infection (LTBI). Recent studies have described potential correlates of risk, in order to inform the development of prognostic tests for TB disease progression. These efforts have included unbiased approaches employing \u201comics\u201d technologies, as well as more directed, hypothesis-driven approaches assessing a small set or even individual selected markers as candidate correlates of TB risk. Unbiased high-throughput screening of blood RNAseq profiles identified signatures of active TB risk in individuals with LTBI, \u22651\u2005year before diagnosis. A recent infant vaccination study identified enhanced expression of T-cell activation markers as a correlate of risk prior to developing TB; conversely, high levels of Ag85A antibodies and high frequencies of interferon (IFN)-\u03b3 specific T-cells were associated with reduced risk of disease. Others have described CD27<jats:sup>\u2212<\/jats:sup>IFN-\u03b3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>T-cells as possibly predictive markers of TB disease. T-cell responses to TB latency antigens, including heparin-binding haemagglutinin and DosR-regulon-encoded antigens have also been correlated with protection.<\/jats:p><jats:p>Further studies are needed to determine whether correlates of risk can be used to prevent active TB through targeted prophylactic treatment, or to allow targeted enrolment into efficacy trials of new TB vaccines and therapeutic drugs.<\/jats:p>","DOI":"10.1183\/13993003.01012-2016","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T04:04:31Z","timestamp":1478923471000},"page":"1751-1763","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":175,"title":["Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis"],"prefix":"10.1183","volume":"48","author":[{"given":"Elisa","family":"Petruccioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Scriba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Petrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hatherill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela M.","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone A.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom H.","family":"Ottenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Denkinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Goletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"2024102100155093000_48.6.1751.1","unstructured":"World Health Organization (WHO). Global Tuberculosis Report 2016. www.who.int\/tb\/publications\/global_report\/en\/ Date last accessed: October 13, 2016. Date last updated: 2016."},{"key":"2024102100155093000_48.6.1751.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903023200901"},{"key":"2024102100155093000_48.6.1751.3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/1756-185X.12708","article-title":"Latent tuberculosis infection detection and active tuberculosis prevention in patients receiving anti-TNF therapy: an Italian nationwide survey","volume":"19","author":"Cantini","year":"2016","journal-title":"Int J Rheum Dis"},{"key":"2024102100155093000_48.6.1751.4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140103"},{"key":"2024102100155093000_48.6.1751.5","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140102"},{"key":"2024102100155093000_48.6.1751.6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028510"},{"key":"2024102100155093000_48.6.1751.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00000712"},{"key":"2024102100155093000_48.6.1751.8","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trv111"},{"key":"2024102100155093000_48.6.1751.9","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12257"},{"key":"2024102100155093000_48.6.1751.10","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2236"},{"key":"2024102100155093000_48.6.1751.11","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0437"},{"key":"2024102100155093000_48.6.1751.12","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140097"},{"key":"2024102100155093000_48.6.1751.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0531-3"},{"key":"2024102100155093000_48.6.1751.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000988"},{"key":"2024102100155093000_48.6.1751.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.03004.x"},{"key":"2024102100155093000_48.6.1751.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2009.01.005"},{"key":"2024102100155093000_48.6.1751.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.09.012"},{"key":"2024102100155093000_48.6.1751.18","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00214014"},{"key":"2024102100155093000_48.6.1751.19","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01245-2015"},{"key":"2024102100155093000_48.6.1751.20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00198813"},{"key":"2024102100155093000_48.6.1751.21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01297-2015"},{"key":"2024102100155093000_48.6.1751.22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114810"},{"key":"2024102100155093000_48.6.1751.23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201405-0967OC"},{"key":"2024102100155093000_48.6.1751.24","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01047-2015"},{"key":"2024102100155093000_48.6.1751.25","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140099"},{"key":"2024102100155093000_48.6.1751.26","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.5.1274-1282.1996"},{"key":"2024102100155093000_48.6.1751.27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-6-95"},{"key":"2024102100155093000_48.6.1751.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2012.12.012"},{"key":"2024102100155093000_48.6.1751.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02742-2"},{"key":"2024102100155093000_48.6.1751.30","unstructured":"QuantiFERON\u00ae-TB Gold Plus (QFT\u00ae-Plus) ELISA Package Insert. www.quantiferon.com\/irm\/content\/PI\/QFT\/PLUS\/2PK-Elisa\/UK.pdf Date last accessed: February 2015. Date last updated: February 2015."},{"key":"2024102100155093000_48.6.1751.31","doi-asserted-by":"crossref","unstructured":"Petruccioli E , Chiacchio T , Pepponi I , et al. First characterization of the CD4 and CD8 T-cell responses to QuantiFERON-TB Plus. J Infect 2016; [In press DOI: 10.1016\/j.jinf.2016.09.008].","DOI":"10.1016\/j.ijmyco.2016.09.063"},{"key":"2024102100155093000_48.6.1751.32","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-179OC"},{"key":"2024102100155093000_48.6.1751.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.06.009"},{"key":"2024102100155093000_48.6.1751.34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101122"},{"key":"2024102100155093000_48.6.1751.35","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu795"},{"key":"2024102100155093000_48.6.1751.36","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243262"},{"key":"2024102100155093000_48.6.1751.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.11.023"},{"key":"2024102100155093000_48.6.1751.38","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1513\/AnnalsATS.201406-262CME","article-title":"ATS Core Curriculum 2014: part I. Adult pulmonary medicine","volume":"11","author":"Nyendak","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"2024102100155093000_48.6.1751.39","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02033-2015"},{"key":"2024102100155093000_48.6.1751.40","doi-asserted-by":"crossref","unstructured":"Barcellini L , Borroni E , Brown J , et al. First evaluation of QuantiFERON-TB Gold Plus performance in contact screening. Eur Respir J 2016 [In press DOI: 10.1183\/13993003.00510-2016].","DOI":"10.1183\/13993003.00510-2016"},{"key":"2024102100155093000_48.6.1751.41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064215"},{"key":"2024102100155093000_48.6.1751.42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015153108"},{"key":"2024102100155093000_48.6.1751.43","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0232OC"},{"key":"2024102100155093000_48.6.1751.44","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70210-9"},{"key":"2024102100155093000_48.6.1751.45","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/S1472-9792(12)70007-0","article-title":"Ten challenges for TB biomarkers","volume":"92","author":"Ottenhoff","year":"2012","journal-title":"Tuberculosis"},{"key":"2024102100155093000_48.6.1751.46","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ612"},{"key":"2024102100155093000_48.6.1751.47","doi-asserted-by":"publisher","DOI":"10.1086\/591504"},{"key":"2024102100155093000_48.6.1751.48","unstructured":"World Health Organization (WHO). Guidelines on the Management of Latent Tuberculosis Infection. Geneva, WHO, 2015."},{"key":"2024102100155093000_48.6.1751.49","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01245-2015"},{"key":"2024102100155093000_48.6.1751.50","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1093\/infdis\/jiu821","article-title":"Defining the needs for next generation assays for tuberculosis","volume":"211: Suppl. 2","author":"Denkinger","year":"2015","journal-title":"J Infect Dis"},{"key":"2024102100155093000_48.6.1751.51","first-page":"331","article-title":"Predictive factors for latent tuberculosis infection among adolescents in a high-burden area in South Africa","volume":"15","author":"Mahomed","year":"2011","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102100155093000_48.6.1751.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01316-1"},{"key":"2024102100155093000_48.6.1751.53","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247"},{"key":"2024102100155093000_48.6.1751.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070630"},{"key":"2024102100155093000_48.6.1751.55","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.jinf.2014.08.006","article-title":"Host RNA signatures for diagnostics: an example from paediatric tuberculosis in Africa","volume":"69: Suppl. 1","author":"Kaforou","year":"2014","journal-title":"J Infect"},{"key":"2024102100155093000_48.6.1751.56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001538"},{"key":"2024102100155093000_48.6.1751.57","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00048-5"},{"key":"2024102100155093000_48.6.1751.58","doi-asserted-by":"crossref","first-page":"86","DOI":"10.15252\/emmm.201505790","article-title":"Concise gene signature for point-of-care classification of tuberculosis","volume":"8","author":"Maertzdorf","year":"2015","journal-title":"EMBO Mol Med"},{"key":"2024102100155093000_48.6.1751.59","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00009114"},{"key":"2024102100155093000_48.6.1751.60","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ebiom.2014.12.001","article-title":"Biomarkers can identify pulmonary tuberculosis in HIV-infected drug users months prior to clinical diagnosis","volume":"2","author":"Sloot","year":"2014","journal-title":"EBioMedicine"},{"key":"2024102100155093000_48.6.1751.61","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201406-1159OC"},{"key":"2024102100155093000_48.6.1751.62","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.64"},{"key":"2024102100155093000_48.6.1751.63","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60177-4"},{"key":"2024102100155093000_48.6.1751.64","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11290"},{"key":"2024102100155093000_48.6.1751.65","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trw016"},{"key":"2024102100155093000_48.6.1751.66","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100090"},{"key":"2024102100155093000_48.6.1751.67","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4049\/jimmunol.157.3.1271","article-title":"Effect of Mycobacterium tuberculosis on HIV replication. Role of immune activation","volume":"157","author":"Goletti","year":"1996","journal-title":"J Immunol"},{"key":"2024102100155093000_48.6.1751.68","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0334OC"},{"key":"2024102100155093000_48.6.1751.69","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115839"},{"key":"2024102100155093000_48.6.1751.70","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6489"},{"key":"2024102100155093000_48.6.1751.71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02573.x"},{"key":"2024102100155093000_48.6.1751.72","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/854507"},{"key":"2024102100155093000_48.6.1751.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.07.009"},{"key":"2024102100155093000_48.6.1751.74","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70884-9"},{"key":"2024102100155093000_48.6.1751.75","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00180"},{"key":"2024102100155093000_48.6.1751.76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043733"},{"key":"2024102100155093000_48.6.1751.77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027284"},{"key":"2024102100155093000_48.6.1751.78","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.diagmicrobio.2016.06.007","article-title":"Use of several immunological markers to model the probability of active tuberculosis","volume":"86","author":"Petruccioli","year":"2016","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2024102100155093000_48.6.1751.79","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.7.3195"},{"key":"2024102100155093000_48.6.1751.80","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01600.x"},{"key":"2024102100155093000_48.6.1751.81","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00055508"},{"key":"2024102100155093000_48.6.1751.82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012577"},{"key":"2024102100155093000_48.6.1751.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.05.002"},{"key":"2024102100155093000_48.6.1751.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.03.017"},{"key":"2024102100155093000_48.6.1751.85","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-333"},{"key":"2024102100155093000_48.6.1751.86","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.5588\/ijtld.16.0342","article-title":"Blood and urine inducible protein 10 as potential markers of disease activity","volume":"20","author":"Petrone","year":"2016","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102100155093000_48.6.1751.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.09.004"},{"key":"2024102100155093000_48.6.1751.88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117424"},{"key":"2024102100155093000_48.6.1751.89","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.993"},{"key":"2024102100155093000_48.6.1751.90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018315"},{"key":"2024102100155093000_48.6.1751.91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000926"},{"key":"2024102100155093000_48.6.1751.92","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00607-14"},{"key":"2024102100155093000_48.6.1751.93","doi-asserted-by":"crossref","unstructured":"Delogu G , Vanini V , Cuzzi G , et al. Lack of response to HBHA in HIV-infected patients with latent tuberculosis infection. Scand J Immunol 2016; [In press DOI: 10.1111\/sji.12493].","DOI":"10.1111\/sji.12493"},{"key":"2024102100155093000_48.6.1751.94","doi-asserted-by":"publisher","DOI":"10.1086\/430930"},{"key":"2024102100155093000_48.6.1751.95","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200012)30:12<3689::AID-IMMU3689>3.0.CO;2-4"},{"key":"2024102100155093000_48.6.1751.96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043285"},{"key":"2024102100155093000_48.6.1751.97","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.03.004"},{"key":"2024102100155093000_48.6.1751.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.03.018"},{"key":"2024102100155093000_48.6.1751.99","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01999-06"},{"key":"2024102100155093000_48.6.1751.100","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02779.x"},{"key":"2024102100155093000_48.6.1751.101","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030846"},{"key":"2024102100155093000_48.6.1751.102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005590"},{"key":"2024102100155093000_48.6.1751.103","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00111-09"},{"key":"2024102100155093000_48.6.1751.104","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00140009"},{"key":"2024102100155093000_48.6.1751.105","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.2.179-186.2006"},{"key":"2024102100155093000_48.6.1751.106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027539"},{"key":"2024102100155093000_48.6.1751.107","first-page":"231","article-title":"The role of the monocyte in tuberculosis","volume":"37","author":"Cunningham","year":"1925","journal-title":"Bull Johns Hopkins Hosp"},{"key":"2024102100155093000_48.6.1751.108","doi-asserted-by":"publisher","DOI":"10.1084\/jem.52.1.113"},{"key":"2024102100155093000_48.6.1751.109","first-page":"252","article-title":"Studies of the blood in experimental tuberculosis: the monocyte\u2013lymphocyte ratio; the anemia\u2013leucopenia phase","volume":"22","author":"Sabin","year":"1926","journal-title":"Transactions of the 22nd Annual Meeting of the National Tuberculosis Association"},{"key":"2024102100155093000_48.6.1751.110","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit494"},{"key":"2024102100155093000_48.6.1751.111","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0120-7"},{"key":"2024102100155093000_48.6.1751.112","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00263-2015"},{"key":"2024102100155093000_48.6.1751.113","doi-asserted-by":"publisher","DOI":"10.1038\/nature09135"},{"key":"2024102100155093000_48.6.1751.114","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.12.003"},{"key":"2024102100155093000_48.6.1751.115","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.ebiom.2015.09.027","article-title":"Distinct transcriptional and anti-mycobacterial profiles of peripheral blood monocytes dependent on the ratio of monocytes: lymphocytes","volume":"2","author":"Naranbhai","year":"2015","journal-title":"EBioMedicine"},{"key":"2024102100155093000_48.6.1751.116","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12916-016-0617-3","article-title":"Human newborn bacille Calmette-Gu\u00e9rin vaccination and risk of tuberculosis disease: a case-control study","volume":"14","author":"Fletcher","year":"2016","journal-title":"BMC Med"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01012-2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:37:17Z","timestamp":1740379037000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01012-2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,11]]},"references-count":116,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,11,30]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1183\/13993003.01012-2016"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01012-2016","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,11]]}}}