{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:45:16Z","timestamp":1790646316052,"version":"4.1.0"},"reference-count":44,"publisher":"European Respiratory Society (ERS)","issue":"3","funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0802826"],"award-info":[{"award-number":["G0802826"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Biomedical Research Centre, Oxfod"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,6,17]]},"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Breathlessness in chronic obstructive pulmonary disease (COPD) is often discordant with airway pathophysiology (\u201cover-perception\u201d). Pulmonary rehabilitation profoundly affects breathlessness, without influencing lung function. Learned associations influence brain mechanisms of sensory perception. We hypothesised that improvements in breathlessness with pulmonary rehabilitation may be explained by changing neural representations of learned associations.<\/jats:p>\n                  <jats:p>In 31 patients with COPD, we tested how pulmonary rehabilitation altered the relationship between brain activity during a breathlessness-related word-cue task (using functional magnetic resonance imaging), and clinical and psychological measures of breathlessness.<\/jats:p>\n                  <jats:p>Changes in ratings of breathlessness word cues positively correlated with changes in activity in the insula and anterior cingulate cortex. Changes in ratings of breathlessness-anxiety negatively correlated with activations in attention regulation and motor networks. Baseline activity in the insula, anterior cingulate cortex and prefrontal cortex correlated with improvements in breathlessness and breathlessness-anxiety.<\/jats:p>\n                  <jats:p>Pulmonary rehabilitation is associated with altered neural responses related to learned breathlessness associations, which can ultimately influence breathlessness perception. These findings highlight the importance of targeting learned associations within treatments for COPD, demonstrating how neuroimaging may contribute to patient stratification and more successful personalised therapy.<\/jats:p>","DOI":"10.1183\/13993003.01029-2017","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T20:10:44Z","timestamp":1505247044000},"page":"1701029","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":100,"title":["Treating breathlessness\n                    <i>via<\/i>\n                    the brain: changes in brain activity over a course of pulmonary rehabilitation"],"prefix":"10.1183","volume":"50","author":[{"given":"Mari","family":"Herigstad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia K.","family":"Faull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Hayen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Maxine","family":"Hardinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Wiech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle T.S.","family":"Pattinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"2024101904245627000_50.3.1701029.1","doi-asserted-by":"crossref","unstructured":"Carel H . Illness: The Cry of the Flesh. Stocksfield, Acumen, 2008.","DOI":"10.1017\/UPO9781844654215"},{"key":"2024101904245627000_50.3.1701029.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2013.06.005"},{"key":"2024101904245627000_50.3.1701029.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2042ST"},{"key":"2024101904245627000_50.3.1701029.4","first-page":"CD003793","article-title":"Pulmonary rehabilitation for chronic obstructive pulmonary disease","volume":"2","author":"McCarthy","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2024101904245627000_50.3.1701029.5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/nur.20359","article-title":"Additional evidence for the affective dimension of dyspnea in patients with COPD","volume":"33","author":"Carrieri-Kohlman","year":"2010","journal-title":"Res Nurs Health"},{"key":"2024101904245627000_50.3.1701029.6","unstructured":"National COPD Audit Programme . Pulmonary rehabilitation: steps to breathe better. National Chronic Obstructive Pulmonary Disease (COPD) Audit Programme: clinical audit of pulmonary rehabilitation services in England and Wales 2015. 2016. www.rcplondon.ac.uk\/projects\/outputs\/pulmonary-rehabilitation-steps-breathe-better Date last accessed: July 21, 2017."},{"key":"2024101904245627000_50.3.1701029.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.015"},{"key":"2024101904245627000_50.3.1701029.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.07.012"},{"key":"2024101904245627000_50.3.1701029.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3950"},{"key":"2024101904245627000_50.3.1701029.10","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12047"},{"key":"2024101904245627000_50.3.1701029.11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21749"},{"key":"2024101904245627000_50.3.1701029.12","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3389\/fpsyg.2015.01150","article-title":"Interoceptive fear learning to mild breathlessness as a laboratory model for unexpected panic attacks","volume":"6","author":"Pappens","year":"2015","journal-title":"Front Psychol"},{"key":"2024101904245627000_50.3.1701029.13","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000204782.49159.79"},{"key":"2024101904245627000_50.3.1701029.14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.neuroimage.2017.01.005","article-title":"Opioid suppression of conditioned anticipatory brain responses to breathlessness","volume":"150","author":"Hayen","year":"2017","journal-title":"Neuroimage"},{"key":"2024101904245627000_50.3.1701029.15","doi-asserted-by":"crossref","unstructured":"Faull OK , Hayen A , Pattinson KTS . Breathlessness and the body: neuroimaging clues for the inferential leap. Cortex 2017; in press. [https:\/\/doi.org\/10.1016\/j.cortex.2017.07.019]","DOI":"10.1101\/117408"},{"key":"2024101904245627000_50.3.1701029.16","doi-asserted-by":"crossref","first-page":"6434987","DOI":"10.1155\/2016\/6434987","article-title":"Brain responses during the anticipation of dyspnea","volume":"2016","author":"Stoeckel","year":"2016","journal-title":"Neural Plast"},{"key":"2024101904245627000_50.3.1701029.17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/YCO.0b013e328363c1fc","article-title":"The psychology of chronic obstructive pulmonary disease","volume":"26","author":"von Leupoldt","year":"2013","journal-title":"Curr Opin Psychiatry"},{"key":"2024101904245627000_50.3.1701029.18","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200105000-00002"},{"key":"2024101904245627000_50.3.1701029.19","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2012.758696"},{"key":"2024101904245627000_50.3.1701029.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2015.12.006"},{"key":"2024101904245627000_50.3.1701029.21","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0416"},{"key":"2024101904245627000_50.3.1701029.22","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"2024101904245627000_50.3.1701029.23","unstructured":"Spielberger CD , Gorsuch RL , Lushene R , et\u00a0al. Manual for the State-Trait Anxiety Inventory. Palo Alto, Consulting Psychologists Press, 1989."},{"key":"2024101904245627000_50.3.1701029.24","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"2024101904245627000_50.3.1701029.25","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.6.1321"},{"key":"2024101904245627000_50.3.1701029.26","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.7.581"},{"key":"2024101904245627000_50.3.1701029.27","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.118521"},{"key":"2024101904245627000_50.3.1701029.28","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.27.1.93"},{"key":"2024101904245627000_50.3.1701029.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7894(97)80047-0"},{"key":"2024101904245627000_50.3.1701029.30","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-3514.67.2.319"},{"key":"2024101904245627000_50.3.1701029.31","doi-asserted-by":"publisher","DOI":"10.4104\/pcrj.2009.00054"},{"key":"2024101904245627000_50.3.1701029.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.006"},{"key":"2024101904245627000_50.3.1701029.33","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.127"},{"key":"2024101904245627000_50.3.1701029.34","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050513"},{"key":"2024101904245627000_50.3.1701029.35","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1378\/chest.13-2071","article-title":"Measurement properties of the incremental shuttle walk test. A\u00a0systematic review","volume":"145","author":"Parreira","year":"2014","journal-title":"Chest"},{"key":"2024101904245627000_50.3.1701029.36","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2810-x"},{"key":"2024101904245627000_50.3.1701029.37","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208332"},{"key":"2024101904245627000_50.3.1701029.38","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt162"},{"key":"2024101904245627000_50.3.1701029.39","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsw024"},{"key":"2024101904245627000_50.3.1701029.40","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2008.525"},{"key":"2024101904245627000_50.3.1701029.41","first-page":"479","article-title":"The effects of altered intrathoracic pressure on resting cerebral blood flow and its response to visual stimulation","volume":"66C","author":"Hayen","year":"2012","journal-title":"Neuroimage"},{"key":"2024101904245627000_50.3.1701029.42","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-3257"},{"key":"2024101904245627000_50.3.1701029.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.12.004"},{"key":"2024101904245627000_50.3.1701029.44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-184"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01029-2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:43:55Z","timestamp":1740361435000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01029-2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9,12]]},"published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1183\/13993003.01029-2017"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01029-2017","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/117390","asserted-by":"object"}]},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}