{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:25:57Z","timestamp":1769163957119,"version":"3.49.0"},"reference-count":22,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,8,12]]},"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Diagnosis and preventive treatment of latent tuberculosis infection (LTBI) among high-risk groups is recommended to achieve tuberculosis (TB) elimination in low-incidence countries.<\/jats:p><jats:p>We studied TB incidence rates among those notified with LTBI in the Netherlands from 2005 to 2013 and analysed associated risk factors. We stratified analyses by target group for screening, and by initiation and completion of preventive treatment.<\/jats:p><jats:p>The incidence for those completing, stopping and not receiving preventive treatment was 187, 436 and 355 per 100\u200a000\u2005person-years for contacts of TB patients, respectively, and 63, 96 and 110 per 100\u200a000\u2005person-years for other target groups. The rate ratio for TB development among contacts compared to other target groups was 3.1 (95% CI 2.0\u20134.9). In both groups, incidence was highest in the first year after diagnosis. Independent factors associated with progression to TB among contacts were age &lt;5\u2005years and stopping preventive treatment within 28\u2005days compared to those not receiving preventive treatment. Among other target groups, being foreign born was the only risk factor associated with the risk of developing TB.<\/jats:p><jats:p>We conclude that the epidemiological impact of preventive treatment is highest in contacts of TB patients and limited in other target groups for LTBI management in the Netherlands.<\/jats:p>","DOI":"10.1183\/13993003.01157-2016","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T01:59:46Z","timestamp":1475805586000},"page":"1420-1428","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Risk of developing tuberculosis disease among persons diagnosed with latent tuberculosis infection in the Netherlands"],"prefix":"10.1183","volume":"48","author":[{"given":"Connie G.M.","family":"Erkens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Slump","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurits","family":"Verhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrieke","family":"Schimmel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Cobelens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"van den Hof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"2024102100134576000_48.5.1420.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60570-0"},{"key":"2024102100134576000_48.5.1420.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00214014"},{"key":"2024102100134576000_48.5.1420.3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01245-2015"},{"key":"2024102100134576000_48.5.1420.4","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01397-2015"},{"key":"2024102100134576000_48.5.1420.5","first-page":"1112","article-title":"Risk factors for developing tuberculosis: a 12-year follow-up of contacts of tuberculosis cases","volume":"14","author":"Mor\u00e1n-Mendoza","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102100134576000_48.5.1420.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201406-1159OC"},{"key":"2024102100134576000_48.5.1420.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0232OC"},{"key":"2024102100134576000_48.5.1420.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60162-8"},{"key":"2024102100134576000_48.5.1420.9","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70187-7"},{"key":"2024102100134576000_48.5.1420.10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.1.36"},{"key":"2024102100134576000_48.5.1420.11","first-page":"555","article-title":"Efficacy of various durations of isoniazid preventive therapy for tuberculosis: five years of follow-up in the IUAT trial","volume":"60","author":"International Union Against Tuberculosis Committee on Prophylaxis","year":"1982","journal-title":"Bull World Health Organ"},{"key":"2024102100134576000_48.5.1420.12","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.3.247"},{"key":"2024102100134576000_48.5.1420.13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1355OC"},{"key":"2024102100134576000_48.5.1420.14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/oxfordjournals.aje.a121593","article-title":"The prognosis of a positive tuberculin reaction in childhood and adolescence","volume":"99","author":"Comstock","year":"1974","journal-title":"Am J Epidemiol"},{"key":"2024102100134576000_48.5.1420.15","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1164\/rccm.201406-1159OC","article-title":"Risk of tuberculosis after recent exposure. A 10-year follow-up study of contacts in Amsterdam","volume":"90","author":"Sloot","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102100134576000_48.5.1420.16","first-page":"CD007545","article-title":"Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB","volume":"7","author":"Sharma","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2024102100134576000_48.5.1420.17","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268806007540"},{"key":"2024102100134576000_48.5.1420.18","unstructured":"KNCV Tuberculosis Foundation. TBC-online. www.tbc-online.nl\/eng\/ziekte\/index.php Date last updated: July 2015."},{"key":"2024102100134576000_48.5.1420.19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-295"},{"key":"2024102100134576000_48.5.1420.20","doi-asserted-by":"crossref","unstructured":"De Vries G , Riesmeijer R . Nationaal Plan Tuberculosebestrijding 2016-2020. Op weg naar eliminatie. [National Plan TB control 2016-2020. Towards Elimination.] Bilthoven, Rijksinstituut voor Volksgezondheid en Milieu, 2016.","DOI":"10.1007\/s12508-017-0074-1"},{"key":"2024102100134576000_48.5.1420.21","unstructured":"Slump E , Erkens CGM , Van Hunen R , et al. Tuberculose in Nederland 2014. Surveillance rapport. [Tuberculosis in the Netherlands 2014. Surveillance report.] Bilthoven, Rijksinstituut voor Volksgezondheid en Milieu, 2015."},{"key":"2024102100134576000_48.5.1420.22","first-page":"D51","article-title":"Tuberculose bij asielzoekers in Nederland [Tuberculosis among asylum-seekers in the Netherlands: a descriptive study among the two largest groups of asylum-seekers]","volume":"160","author":"de Vries","year":"2016","journal-title":"Ned Tijdschr Geneeskd"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01157-2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:36:40Z","timestamp":1740379000000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01157-2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,6]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,10,31]]},"published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1183\/13993003.01157-2016"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01157-2016","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,6]]}}}