{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:14:23Z","timestamp":1792005263513,"version":"4.4.0"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"5","funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,7,27]]},"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial.<\/jats:p><jats:p>To evaluate the prevalence and stability of a high level of blood eosinophils (\u2265300\u2005cells\u00b7\u03bcL<jats:sup>\u20131<\/jats:sup>) and its relationship to outcomes, we determined blood eosinophils at baseline and over 2\u2005years in 424 COPD patients (forced expiratory volume in 1\u2005s (FEV<jats:sub>1<\/jats:sub>) 60% predicted) and 67 smokers without COPD from the CHAIN cohort, and in 308 COPD patients (FEV<jats:sub>1<\/jats:sub>60% predicted) in the BODE cohort. We related eosinophil levels to exacerbations and survival using Cox hazard analysis.<\/jats:p><jats:p>In COPD patients, 15.8% in the CHAIN cohort and 12.3% in the BODE cohort had persistently elevated blood eosinophils at all three visits. A significant proportion (43.8%) of patients had counts that oscillated above and below the cut-off points, while the rest had persistent eosinophil levels &lt;300\u2005cells\u00b7\u03bcL<jats:sup>\u20131<\/jats:sup>. A similar eosinophil blood pattern was observed in controls. Exacerbation rates did not differ in patients with and without eosinophilia. All-cause mortality was lower in patients with high eosinophils compared with those with values &lt;300\u2005cells\u00b7\u03bcL<jats:sup>\u20131<\/jats:sup>(15.8%<jats:italic>versus<\/jats:italic>33.7%; p=0.026).<\/jats:p><jats:p>In patients with COPD, blood eosinophils \u2265300\u2005cells\u00b7\u03bcL<jats:sup>\u20131<\/jats:sup>persisting over 2\u2005years was not a risk factor for COPD exacerbations. High eosinophil count was associated with better survival.<\/jats:p>","DOI":"10.1183\/13993003.01162-2017","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T14:48:21Z","timestamp":1511794101000},"page":"1701162","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":155,"title":["Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD"],"prefix":"10.1183","volume":"50","author":[{"given":"Ciro","family":"Casanova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartolome R.","family":"Celli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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