{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:59:18Z","timestamp":1790326758427,"version":"4.1.0"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["\u201cInvestissements d\u2019avenir\u201d program (ANR-15-ID"],"award-info":[{"award-number":["\u201cInvestissements d\u2019avenir\u201d program (ANR-15-ID"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MIAI @ university Grenoble Alpes","award":["ANR-19-P3IA-0003"],"award-info":[{"award-number":["ANR-19-P3IA-0003"]}]},{"DOI":"10.13039\/100017647","name":"ResMed","doi-asserted-by":"publisher","award":["unrestricted grant"],"award-info":[{"award-number":["unrestricted grant"]}],"id":[{"id":"10.13039\/100017647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2023,11,26]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Continuation of continuous positive airway pressure (CPAP) therapy after initial prescription has been shown to reduce all-cause mortality<jats:italic>versus<\/jats:italic>therapy termination. However, there is a lack of data on the rates and impact of resuming CPAP in patients with obstructive sleep apnoea (OSA). This analysis determined the prevalence of CPAP resumption in the year after termination, characterised determinants of CPAP resumption, and examined the impact of CPAP resumption on all-cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>French national health insurance reimbursement system data for adults aged \u226518\u2005years were used. CPAP prescription was identified by specific treatment codes. Patients who resumed CPAP after first therapy termination and continued to use CPAP for 1\u2005year were matched with those who resumed CPAP then terminated therapy for a second time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 103\u2009091 individuals with a first CPAP termination, 26% resumed CPAP over the next 12\u2005months, and 65% of these were still using CPAP 1\u2005year later. Significant predictors of CPAP continuation after resumption included male sex, hypertension and CPAP prescription by a pulmonologist. In the matched population, the risk of all-cause death was 38% lower in individuals who continued using CPAP after therapy resumption<jats:italic>versus<\/jats:italic>those who had a second therapy discontinuation (hazard ratio 0.62, 95% CI 0.48\u20130.79; p=0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that individuals with OSA who fail initial therapy with CPAP should be offered a second trial with the device to ensure that effective therapy is not withheld from those who might benefit.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.01171-2023","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T11:45:21Z","timestamp":1703245521000},"page":"2301171","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["CPAP resumption after a first termination and impact on all-cause mortality in France"],"prefix":"10.1183","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-2358","authenticated-orcid":false,"given":"Jean-Louis","family":"P\u00e9pin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-6529","authenticated-orcid":false,"given":"Renaud","family":"Tamisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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