{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:19:01Z","timestamp":1788023941436,"version":"build-2784847793"},"reference-count":42,"publisher":"European Respiratory Society (ERS)","issue":"4","funder":[{"DOI":"10.13039\/100017647","name":"ResMed","doi-asserted-by":"crossref","award":["ROSA"],"award-info":[{"award-number":["ROSA"]}],"id":[{"id":"10.13039\/100017647","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100003305","name":"ResMed Foundation","doi-asserted-by":"publisher","award":["WEST\/ROSA"],"award-info":[{"award-number":["WEST\/ROSA"]}],"id":[{"id":"10.13039\/100003305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,8,13]]},"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>We sought to establish whether continuous positive airway pressure (CPAP) for obstructive sleep apnoea (OSA) in people with type 2 diabetes and diabetic macular oedema (DMO) improved visual acuity.<\/jats:p><jats:p>We randomly assigned 131 eligible patients aged 30\u201385\u2005years from 23 UK centres with significant DMO causing visual impairment (LogMAR letters identified \u226539 and \u226478, score 0.92\u20130.14) plus severe OSA on screening to either usual ophthalmology care (n=67) or usual ophthalmology care plus CPAP (n=64) for 12\u2005months.<\/jats:p><jats:p>Mean age of participants was 64\u2005years, 73% male, mean body mass index 35.0\u2005kg\u00b7m<jats:sup>\u2212<\/jats:sup><jats:sup>2<\/jats:sup>. Mean 4% oxygen desaturation index was 36\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>. There was no significant difference in the visual acuity at 12\u2005months between the CPAP group and the control group (mean LogMAR 0.33 (95% CI 0.29\u20130.37)<jats:italic>versus<\/jats:italic>0.31 (95% CI 0.27\u20130.35); p=0.39), and no significant correlation between change in LogMAR and average CPAP use. The median\u00b1<jats:sc>sd<\/jats:sc>(range) daily CPAP use was 3.33\u00b12.25 (0\u20137.93)\u2005h at 3\u2005months, 3.19\u00b12.54 (0\u20138.07)\u2005h at 6\u2005months and 3.21\u00b12.70 (0\u20137.98)\u2005h at 12\u2005months.<\/jats:p><jats:p>CPAP therapy for OSA did not improve visual acuity in people with type 2 diabetes and DMO compared with usual care alone over 12\u2005months.<\/jats:p>","DOI":"10.1183\/13993003.01177-2018","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T13:06:51Z","timestamp":1535634411000},"page":"1801177","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial"],"prefix":"10.1183","volume":"52","author":[{"given":"Sophie 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