{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:29:57Z","timestamp":1792877397075,"version":"4.5.0"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006044","name":"Astellas Pharma Europe","doi-asserted-by":"publisher","award":["Investgator Driven Study"],"award-info":[{"award-number":["Investgator Driven Study"]}],"id":[{"id":"10.13039\/501100006044","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","award":["Test Kit Donations"],"award-info":[{"award-number":["Test Kit Donations"]}],"id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,12,19]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Chronic pulmonary aspergillosis (CPA) complicates treated pulmonary tuberculosis (TB), with high 5-year mortality. We measured CPA prevalence in this group.<\/jats:p>\n                  <jats:p>\n                    398 Ugandans with treated pulmonary TB underwent clinical assessment, chest radiography and\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    -specific IgG measurement. 285 were resurveyed 2\u2005years later, including computed tomography of the thorax in 73 with suspected CPA. CPA was diagnosed in patients without active TB who had raised\n                    <jats:italic>Aspergillus-<\/jats:italic>\n                    specific IgG, radiological features of CPA and chronic cough or haemoptysis.\n                  <\/jats:p>\n                  <jats:p>\n                    Author-defined CPA was present in 14 (4.9%, 95% CI 2.8\u20137.9%) resurvey patients. CPA was significantly more common in those with chest radiography cavitation (26%\n                    <jats:italic>versus<\/jats:italic>\n                    0.8%; p&lt;0.001), but possibly less frequent in HIV co-infected patients (3%\n                    <jats:italic>versus<\/jats:italic>\n                    6.7%; p=0.177\n                    <jats:italic>)<\/jats:italic>\n                    . The annual rate of new CPA development between surveys was 6.5% in those with chest radiography cavitation and 0.2% in those without (p&lt;0.001). Absence of cavitation and pleural thickening on chest radiography had 100% negative predictive value for CPA. The combination of raised\n                    <jats:italic>Aspergillus-<\/jats:italic>\n                    specific IgG, chronic cough or haemoptysis and chest radiography cavitation had 85.7% sensitivity and 99.6% specificity for CPA diagnosis.\n                  <\/jats:p>\n                  <jats:p>CPA commonly complicates treated pulmonary TB with residual chest radiography cavitation. Chest radiography alone can exclude CPA. Addition of serology can diagnose CPA with reasonable accuracy.<\/jats:p>","DOI":"10.1183\/13993003.01184-2018","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T08:24:43Z","timestamp":1548923083000},"page":"1801184","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":150,"title":["Chronic pulmonary aspergillosis commonly complicates treated pulmonary tuberculosis with residual\u00a0cavitation"],"prefix":"10.1183","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-2776","authenticated-orcid":false,"given":"Iain D.","family":"Page","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Byanyima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharath","family":"Hosmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Onyachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyprian","family":"Opira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sawyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sharman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Denning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"2024102100462878000_53.3.1801184.1","unstructured":"World Health Organization . 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Improving the diagnosis and treatment of smear-negative pulmonary and extrapulmonary tuberculosis among adults and adolescents. Recommendations for HIV-prevalent and resource-constrained settings. 2006. www.who.int\/tb\/publications\/2006\/tbhiv_recommendations.pdf Date last accessed: February 15, 2018."},{"key":"2024102100462878000_53.3.1801184.40","unstructured":"World Health Organization . 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