{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:57:01Z","timestamp":1789826221010,"version":"4.0.1"},"reference-count":45,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007634","name":"Ida Montini Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007634","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Allergy Research Foundation"},{"name":"Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital"},{"name":"Pirkanmaa Regional Fund of the Finnish Cultural Foundation"},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00d6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008368","name":"Suomen Tuberkuloosin Vastustamisyhdistyksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008368","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Medical Research Fund of Sein\u00e4joki Central Hospital"},{"DOI":"10.13039\/501100008309","name":"Hengityssairauksien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2020,9,21]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity has been associated with poor outcomes of asthma in cross-sectional studies, but long-term effect of obesity on asthma remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To study the effects of obesity, found at the time of diagnosis of adult-onset asthma, on 12-year prognosis by focusing on oral corticosteroid (OCS) use and respiratory-related hospital admissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with adult-onset asthma (n=203) were divided into three categories based on diagnostic body mass index (BMI) (&lt;25 kg\u00b7m<jats:sup>\u22122<\/jats:sup>, 25\u201329.9 kg\u00b7m<jats:sup>\u22122<\/jats:sup>, \u226530\u2005kg\u00b7m<jats:sup>\u22122<\/jats:sup>) and followed for 12\u2005years as part of the Sein\u00e4joki Adult Asthma Study. Self-reported and dispensed OCS were assessed for the 12-year period. Data on hospital admissions were analysed based on medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>12\u2005years after diagnosis, 86% of the patients who were obese (BMI \u226530\u2005kg\u00b7m<jats:sup>\u22122<\/jats:sup>) at diagnosis remained obese. During the follow-up, no difference was found in weight gain between the BMI categories. During the 12-year follow-up, patients obese at diagnosis reported more frequent use of OCS courses (46.9%<jats:italic>versus<\/jats:italic>23.1%, p=0.028), were dispensed OCS more often (81.6%<jats:italic>versus<\/jats:italic>56.9%, p=0.014) and at higher doses (median 1350 (interquartile range 280\u20133180) mg<jats:italic>versus<\/jats:italic>600 (0\u20131650) mg prednisolone, p=0.010) compared to normal-weight patients. Furthermore, patients who were obese had more often one or more respiratory-related hospitalisations compared to normal-weight patients (38.8%<jats:italic>versus<\/jats:italic>16.9%, p=0.033). In multivariate logistic regression analyses, obesity predicted OCS use and hospital admissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In adult-onset asthma, patients obese at diagnosis mostly remained obese at long-term and had more exacerbations and respiratory-related hospital admissions compared to normal-weight patients during 12-year follow-up. Weight loss should be a priority in their treatment to prevent this outcome.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.01209-2020","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T21:45:11Z","timestamp":1602193511000},"page":"2001209","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Long-term prognosis of new adult-onset asthma in obese patients"],"prefix":"10.1183","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8758-2431","authenticated-orcid":false,"given":"Pinja","family":"Ilmarinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienn","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-4508","authenticated-orcid":false,"given":"Leena E.","family":"Tuomisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-8446","authenticated-orcid":false,"given":"Iida","family":"V\u00e4h\u00e4talo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onni","family":"Niemel\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pentti","family":"Nieminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kankaanranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"2024102102022983000_57.4.2001209.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1717OC"},{"key":"2024102102022983000_57.4.2001209.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00054304"},{"key":"2024102102022983000_57.4.2001209.3","doi-asserted-by":"crossref","first-page":"514868","DOI":"10.1155\/2015\/514868","article-title":"Phenotypes, risk factors and mechanisms of adult-onset asthma","volume":"2015","author":"Ilmarinen","year":"2015","journal-title":"Mediators Inflamm"},{"key":"2024102102022983000_57.4.2001209.4","doi-asserted-by":"crossref","first-page":"3690628","DOI":"10.1155\/2016\/3690628","article-title":"Emerging comorbidities in adult asthma: risks, clinical associations and mechanisms","volume":"2016","author":"Kankaanranta","year":"2016","journal-title":"Mediators Inflamm"},{"key":"2024102102022983000_57.4.2001209.5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2959"},{"key":"2024102102022983000_57.4.2001209.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.036"},{"key":"2024102102022983000_57.4.2001209.7","doi-asserted-by":"crossref","first-page":"607192","DOI":"10.1155\/2014\/607192","article-title":"Body mass index and comorbidities in adult severe asthmatics","volume":"2014","author":"Bruno","year":"2014","journal-title":"Biomed Res Int"},{"key":"2024102102022983000_57.4.2001209.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1754OC"},{"key":"2024102102022983000_57.4.2001209.9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jaip.2017.01.027","article-title":"Cluster analysis on longitudinal data of patients with adult-onset asthma","volume":"5","author":"Ilmarinen","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2024102102022983000_57.4.2001209.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0896OC"},{"key":"2024102102022983000_57.4.2001209.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.041"},{"key":"2024102102022983000_57.4.2001209.12","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2678"},{"key":"2024102102022983000_57.4.2001209.13","doi-asserted-by":"publisher","DOI":"10.1038\/npjpcrm.2015.42"},{"key":"2024102102022983000_57.4.2001209.14","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.10.806"},{"key":"2024102102022983000_57.4.2001209.15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.rmed.2016.06.017","article-title":"A 12-year prognosis of adult-onset asthma: Seinajoki Adult Asthma Study","volume":"117","author":"Tuomisto","year":"2016","journal-title":"Respir Med"},{"key":"2024102102022983000_57.4.2001209.16","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00850-2016"},{"key":"2024102102022983000_57.4.2001209.17","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02198-2015"},{"key":"2024102102022983000_57.4.2001209.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90423-1"},{"key":"2024102102022983000_57.4.2001209.19","unstructured":"Global Initiative for Asthma (GINA) . Global Strategy for Asthma Management and Prevention. 2010. Available from: www.ginasthma.org\/"},{"key":"2024102102022983000_57.4.2001209.20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7061.862"},{"key":"2024102102022983000_57.4.2001209.21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"2024102102022983000_57.4.2001209.22","unstructured":"Global Initiative for Asthma (GINA) . Global Strategy for Asthma Management and Prevention. 2002. Available from: www.ginasthma.org\/"},{"key":"2024102102022983000_57.4.2001209.23","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.2500\/aap.2014.35.3773","article-title":"Overweight and obesity as risk factors for impaired lung function in patients with asthma: a real-life experience","volume":"35","author":"Ciprandi","year":"2014","journal-title":"Allergy Asthma Proc"},{"key":"2024102102022983000_57.4.2001209.24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-150"},{"key":"2024102102022983000_57.4.2001209.25","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-2336"},{"key":"2024102102022983000_57.4.2001209.26","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jaip.2016.11.007","article-title":"Identifying risk of future asthma attacks using UK medical record data: a respiratory effectiveness group initiative","volume":"5","author":"Blakey","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2024102102022983000_57.4.2001209.27","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaip.2015.03.017","article-title":"Prospective study on the relationship of obesity to asthma impairment and risk","volume":"3","author":"Schatz","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2024102102022983000_57.4.2001209.28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12890-017-0571-7","article-title":"Burden of asthma and COPD overlap (ACO) in Taiwan: a nationwide population-based study","volume":"18","author":"Shantakumar","year":"2018","journal-title":"BMC Pulm Med"},{"key":"2024102102022983000_57.4.2001209.29","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00077205"},{"key":"2024102102022983000_57.4.2001209.30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-076OC"},{"key":"2024102102022983000_57.4.2001209.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02855.x"},{"key":"2024102102022983000_57.4.2001209.32","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.3.565"},{"key":"2024102102022983000_57.4.2001209.33","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jaci.2018.02.004","article-title":"Obesity and asthma","volume":"141","author":"Peters","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2024102102022983000_57.4.2001209.34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1378\/chest.13-1796","article-title":"Mediator effect of depressive symptoms on the association between BMI and asthma control in adults","volume":"146","author":"Boudreau","year":"2014","journal-title":"Chest"},{"key":"2024102102022983000_57.4.2001209.35","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/all.13370","article-title":"Comorbid \u201ctreatable traits\u201d in difficult asthma: current evidence and clinical evaluation","volume":"73","author":"Tay","year":"2018","journal-title":"Allergy"},{"key":"2024102102022983000_57.4.2001209.36","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jaip.2014.06.005","article-title":"High blood eosinophil count is a risk factor for future asthma exacerbations in adult persistent asthma","volume":"2","author":"Zeiger","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2024102102022983000_57.4.2001209.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.034"},{"key":"2024102102022983000_57.4.2001209.38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jaci.2015.08.019","article-title":"Menopause as a predictor of new-onset asthma: a longitudinal Northern European population study","volume":"137","author":"Triebner","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2024102102022983000_57.4.2001209.39","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1838"},{"key":"2024102102022983000_57.4.2001209.40","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00139810"},{"key":"2024102102022983000_57.4.2001209.41","doi-asserted-by":"publisher","DOI":"10.1378\/chest.05-3084"},{"key":"2024102102022983000_57.4.2001209.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.06.011"},{"key":"2024102102022983000_57.4.2001209.43","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jaci.2014.12.1931","article-title":"Risk of an asthma exacerbation after bariatric surgery in adults","volume":"136","author":"Hasegawa","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2024102102022983000_57.4.2001209.44","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7238.827"},{"key":"2024102102022983000_57.4.2001209.45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/ACI.0000000000000494","article-title":"Asthma, obesity and targeted interventions: an update","volume":"19","author":"Ricketts","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01209-2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:30:01Z","timestamp":1740375001000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01209-2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,1]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1183\/13993003.01209-2020"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01209-2020","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]}}}