{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:52:05Z","timestamp":1771015925766,"version":"3.50.1"},"reference-count":23,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2023,8,4]]},"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1183\/13993003.01253-2023","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:30:20Z","timestamp":1698309020000},"page":"2301253","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Cystic fibrosis and the cardiovascular system: the unexpected heartache"],"prefix":"10.1183","volume":"62","author":[{"given":"Helge","family":"Hebestreit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina S.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"2024102012360104000_62.4.2301253.1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcf.2021.04.016","article-title":"Cardiovascular complications in cystic fibrosis: a review of the literature","volume":"21","author":"Poore","year":"2022","journal-title":"J Cyst Fibros"},{"key":"2024102012360104000_62.4.2301253.2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s44161-022-00030-y","article-title":"Identifying and preventing cardiovascular disease in patients with cystic fibrosis","volume":"1","author":"Saunders","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"2024102012360104000_62.4.2301253.3","doi-asserted-by":"crossref","first-page":"106606","DOI":"10.1016\/j.rmed.2021.106606","article-title":"Outcomes of SARS-CoV-2 infection in patients with cystic fibrosis: a multicenter retrospective research network study","volume":"188","author":"Hadi","year":"2021","journal-title":"Respir Med"},{"key":"2024102012360104000_62.4.2301253.4","first-page":"e16723","article-title":"Cardiovascular system involvement in cystic fibrosis","volume":"13","author":"Shah","year":"2021","journal-title":"Cureus"},{"key":"2024102012360104000_62.4.2301253.5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jcf.2021.11.012","article-title":"Effect of elexacaftor\u2013tezacaftor\u2013ivacaftor on body weight and metabolic parameters in adults with cystic fibrosis","volume":"21","author":"Petersen","year":"2022","journal-title":"J Cyst Fibros"},{"key":"2024102012360104000_62.4.2301253.6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/jcm10010023","article-title":"Real-world safety of CFTR modulators in the treatment of cystic fibrosis: a systematic review","volume":"10","author":"Dagenais","year":"2020","journal-title":"J Clin Med"},{"key":"2024102012360104000_62.4.2301253.7","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00174-2023"},{"key":"2024102012360104000_62.4.2301253.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.009"},{"key":"2024102012360104000_62.4.2301253.9","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001078"},{"key":"2024102012360104000_62.4.2301253.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2019-000456"},{"key":"2024102012360104000_62.4.2301253.11","doi-asserted-by":"crossref","unstructured":"Meltzer LJ , Gross JE . Characterization of sleep in emerging adults with cystic fibrosis on elexacaftor\/tezacaftor\/ivacaftor. J Cyst Fibros 2023; in press [https:\/\/doi.org\/10.1016\/j.jcf.2023.05.005]. doi:10.1016\/j.jcf.2023.05.005","DOI":"10.1016\/j.jcf.2023.05.005"},{"key":"2024102012360104000_62.4.2301253.12","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1002\/ppul.26078","article-title":"Elexacaftor\u2013tezacaftor\u2013ivacaftor improves exercise capacity in adolescents with cystic fibrosis","volume":"57","author":"Causer","year":"2022","journal-title":"Pediatr Pulmonol"},{"key":"2024102012360104000_62.4.2301253.13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/ppul.26243","article-title":"Effect of Trikafta on bone density, body composition and exercise capacity in CF: a pilot study","volume":"58","author":"Gur","year":"2023","journal-title":"Pediatr Pulmonol"},{"key":"2024102012360104000_62.4.2301253.14","doi-asserted-by":"publisher","DOI":"10.1159\/000341479"},{"key":"2024102012360104000_62.4.2301253.15","doi-asserted-by":"crossref","first-page":"104384","DOI":"10.1016\/j.ebiom.2022.104384","article-title":"Restoring myocardial infarction-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator","volume":"86","author":"Vanherle","year":"2022","journal-title":"EBioMedicine"},{"key":"2024102012360104000_62.4.2301253.16","doi-asserted-by":"crossref","unstructured":"Lopez A , Daly C , Vega-Hernandez G , et al. Elexacaftor\/tezacaftor\/ivacaftor projected survival and long-term health outcomes in people with cystic fibrosis homozygous for F508del. J Cyst Fibros 2023; in press [https:\/\/doi.org\/10.1016\/j.jcf.2023.02.004]. doi:10.1016\/j.jcf.2023.02.004","DOI":"10.1016\/j.jcf.2023.02.004"},{"key":"2024102012360104000_62.4.2301253.17","doi-asserted-by":"crossref","first-page":"e299","DOI":"10.1161\/CIR.0000000000001104","article-title":"Emerging evidence on coronary heart disease screening in kidney and liver transplantation candidates: a scientific statement from the American Heart Association: endorsed by the American Society of Transplantation","volume":"146","author":"Cheng","year":"2022","journal-title":"Circulation"},{"key":"2024102012360104000_62.4.2301253.18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.15450"},{"key":"2024102012360104000_62.4.2301253.19","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00495-2022"},{"key":"2024102012360104000_62.4.2301253.20","doi-asserted-by":"crossref","unstructured":"Steinack C , Ernst M , Beuschlein F , et al. Improved glucose tolerance after initiation of elexacaftor\/tezacaftor\/ivacaftor in adults with cystic fibrosis. J Cyst Fibros 2023; in press [https:\/\/doi.org\/10.1016\/j.jcf.2023.01.004]. doi:10.1016\/j.jcf.2023.01.004","DOI":"10.1016\/j.jcf.2023.01.004"},{"key":"2024102012360104000_62.4.2301253.21","doi-asserted-by":"crossref","first-page":"e15756","DOI":"10.1016\/j.heliyon.2023.e15756","article-title":"Elexacaftor\u2013tezacaftor\u2013ivacaftor treatment improves systemic infection parameters and Pseudomonas aeruginosa colonization rate in patients with cystic fibrosis a monocentric observational study","volume":"9","author":"Schnell","year":"2023","journal-title":"Heliyon"},{"key":"2024102012360104000_62.4.2301253.22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1164\/rccm.202008-3176LE","article-title":"Safety and efficacy of elexacaftor\/tezacaftor\/ivacaftor for 24 weeks or longer in people with cystic fibrosis and one or more F508del alleles: interim results of an open-label phase 3 clinical trial","volume":"203","author":"Griese","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102012360104000_62.4.2301253.23","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.3390\/jcm11236900","article-title":"Cystic fibrosis patients with F508del\/minimal function genotype: laboratory and nutritional evaluations after one year of elexacaftor\/tezacaftor\/ivacaftor treatment","volume":"11","author":"Carnovale","year":"2022","journal-title":"J Clin Med"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01253-2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:17:08Z","timestamp":1740381428000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01253-2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,10,26]]},"published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1183\/13993003.01253-2023"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01253-2023","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}