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Primary outcomes were inspiratory capacity prior to exercise and exercise endurance time during constant work-rate cycle ergometry to symptom limitation at 75% of peak incremental work rate after 6\u2005weeks (2\u2005h post-dose).<\/jats:p><jats:p>295 and 291 patients were treated in MORACTO 1 and 2, respectively. Tiotropium\/olodaterol 2.5\/5 and 5\/5\u2005\u00b5g provided significant improvements in inspiratory capacity<jats:italic>versus<\/jats:italic>placebo and monotherapies (p&lt;0.0001), and significant improvements in exercise endurance time<jats:italic>versus<\/jats:italic>placebo (p&lt;0.0001). Intensity of breathing discomfort was reduced following both doses of tiotropium\/olodaterol<jats:italic>versus<\/jats:italic>placebo (p&lt;0.0001).<\/jats:p><jats:p>Once-daily tiotropium\/olodaterol yielded improvements in lung hyperinflation<jats:italic>versus<\/jats:italic>placebo and statistically significant improvements<jats:italic>versus<\/jats:italic>monotherapies. Tiotropium\/olodaterol also showed improvements in dyspnoea and exercise tolerance<jats:italic>versus<\/jats:italic>placebo but not consistently<jats:italic>versus<\/jats:italic>monotherapies.<\/jats:p>","DOI":"10.1183\/13993003.01348-2016","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T19:37:23Z","timestamp":1493149043000},"page":"1601348","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":57,"title":["Effects of combined tiotropium\/olodaterol on inspiratory capacity and exercise endurance in COPD"],"prefix":"10.1183","volume":"49","author":[{"given":"Denis E.","family":"O'Donnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Casaburi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Frith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kirsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"De Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Maltais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"2024101903474925000_49.4.1601348.1","doi-asserted-by":"publisher","DOI":"10.1080\/15412550701480620"},{"key":"2024101903474925000_49.4.1601348.2","doi-asserted-by":"publisher","DOI":"10.1080\/15412550701480265"},{"key":"2024101903474925000_49.4.1601348.3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/15412550701480455","article-title":"Dyspnea and activity limitation in COPD: mechanical factors","volume":"4","author":"O'Donnell","year":"2007","journal-title":"COPD"},{"key":"2024101903474925000_49.4.1601348.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1873OC"},{"key":"2024101903474925000_49.4.1601348.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00046814"},{"key":"2024101903474925000_49.4.1601348.6","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. 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