{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:50:59Z","timestamp":1787503859143,"version":"build-2736575974"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"5","funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,1,10]]},"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Identification of a biomarker that predicts response to inhaled corticosteroids (ICS) would help evaluate the risk\/benefit profile of ICS in chronic obstructive pulmonary disease (COPD) and guide treatment.<\/jats:p>\n                  <jats:p>\n                    The ISOLDE study randomised 751 patients (mean post-bronchodilator forced expiratory volume in 1\u2009s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ) 1.4\u2005L: 50% predicted normal) to fluticasone propionate 500\u2005\u03bcg twice daily or placebo for 3\u2005years, finding no difference in FEV\n                    <jats:sub>1<\/jats:sub>\n                    rate of decline between treatments (p=0.16) and a significant reduction in median exacerbation rate with fluticasone propionate\n                    <jats:italic>versus<\/jats:italic>\n                    placebo (p=0.026). We re-analysed ISOLDE results by baseline blood eosinophil count to investigate whether eosinophil level predicts ICS benefit.\n                  <\/jats:p>\n                  <jats:p>\n                    Patients with eosinophils &lt;2% (n=456) had a similar rate of post-bronchodilator FEV\n                    <jats:sub>1<\/jats:sub>\n                    decline with fluticasone propionate as placebo (\u20132.9\u2005mL\u00b7year\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; p=0.688). With eosinophils \u22652% (n=214), the rate of decline decreased by 33.9\u2005mL\u00b7year\n                    <jats:sup>\u22121<\/jats:sup>\n                    with fluticasone propionate\n                    <jats:italic>versus<\/jats:italic>\n                    placebo (p=0.003). Exacerbation rate reduction on ICS for fluticasone propionate\n                    <jats:italic>versus<\/jats:italic>\n                    placebo was higher in the eosinophil &lt;2% group compared with the \u22652% group; time-to-first moderate\/severe exacerbation was not different between treatments in either group.\n                  <\/jats:p>\n                  <jats:p>\n                    A baseline blood eosinophil count of \u22652% identifies a group of COPD patients with slower rates of decline in FEV\n                    <jats:sub>1<\/jats:sub>\n                    when treated with ICS: prospective testing of this hypothesis is now warranted.\n                  <\/jats:p>","DOI":"10.1183\/13993003.01370-2015","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:39:03Z","timestamp":1456439943000},"page":"1374-1382","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":199,"title":["Blood eosinophils as a marker of response to inhaled corticosteroids in COPD"],"prefix":"10.1183","volume":"47","author":[{"given":"Neil C.","family":"Barnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Lettis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.A.","family":"Calverley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"2024102023550925000_47.5.1374.1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management and Prevention of COPD. www.goldcopd.org\/guidelines-global-strategy-for-diagnosis-management.html Date last accessed: June 19, 2015. Date last updated: January 2015."},{"key":"2024102023550925000_47.5.1374.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105482"},{"key":"2024102023550925000_47.5.1374.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12459-2"},{"key":"2024102023550925000_47.5.1374.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063070"},{"key":"2024102023550925000_47.5.1374.5","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70040-7"},{"key":"2024102023550925000_47.5.1374.6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2992"},{"key":"2024102023550925000_47.5.1374.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00193908"},{"key":"2024102023550925000_47.5.1374.8","first-page":"CD010115","article-title":"Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease","volume":"3","author":"Kew","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2024102023550925000_47.5.1374.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7245.1297"},{"key":"2024102023550925000_47.5.1374.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146306"},{"key":"2024102023550925000_47.5.1374.11","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202646"},{"key":"2024102023550925000_47.5.1374.12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.5.9154853"},{"key":"2024102023550925000_47.5.1374.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02872-5"},{"key":"2024102023550925000_47.5.1374.14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1553OC"},{"key":"2024102023550925000_47.5.1374.15","first-page":"P2817","article-title":"Blood eosinophil count as a biomarker of ICS effectiveness in reducing exacerbation rates in COPD","volume":"44: Suppl. 58","author":"Pascoe","year":"2014","journal-title":"Eur Respir J"},{"key":"2024102023550925000_47.5.1374.16","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00106-X"},{"key":"2024102023550925000_47.5.1374.17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0235LE"},{"key":"2024102023550925000_47.5.1374.18","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9811041"},{"key":"2024102023550925000_47.5.1374.19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.6.1321"},{"key":"2024102023550925000_47.5.1374.20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00161507"},{"key":"2024102023550925000_47.5.1374.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10019-3"},{"key":"2024102023550925000_47.5.1374.22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906243402503"},{"key":"2024102023550925000_47.5.1374.23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432601"},{"key":"2024102023550925000_47.5.1374.24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712-1869OC"},{"key":"2024102023550925000_47.5.1374.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(99)90001-X"},{"key":"2024102023550925000_47.5.1374.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909883"},{"key":"2024102023550925000_47.5.1374.27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407154"},{"key":"2024102023550925000_47.5.1374.28","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010037"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01370-2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:31:27Z","timestamp":1740360687000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01370-2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,4,30]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1183\/13993003.01370-2015"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01370-2015","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,25]]}}}