{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:49:30Z","timestamp":1789444170321,"version":"build-2803163510"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,3,8]]},"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Uncontrolled wheezing disorder is common in preschoolers and disease control assessment is challenging as parents frequently overestimate the extent to which their child's disease is controlled. This is the first study of forced expiratory volume in<jats:italic>t<\/jats:italic>\u2005s (FEV<jats:sub><jats:italic>t<\/jats:italic><\/jats:sub>)\/forced vital capacity (FVC) ratio measurements (<jats:italic>i.e.<\/jats:italic>FEV<jats:sub>1<\/jats:sub>\/FVC, FEV<jats:sub>0.75<\/jats:sub>\/FVC and FEV<jats:sub>0.5<\/jats:sub>\/FVC) in wheezy preschoolers in relation to disease control. Our objective was to evaluate whether FEV<jats:sub><jats:italic>t<\/jats:italic><\/jats:sub>\/FVC ratios less than the lower limit of normal (LLN; z-score &lt;\u22121.64) were associated with uncontrolled wheezing disorder in preschoolers.<\/jats:p><jats:p>Valid FVC, FEV<jats:sub>1<\/jats:sub>, FEV<jats:sub>0.75<\/jats:sub>and FEV<jats:sub>0.5<\/jats:sub>values were obtained in 92 healthy and 125 wheezy (62% uncontrolled) children (3\u20135\u2005years). Associations between spirometry value &lt;LLN, disease classification (healthy\/wheezy) and disease control classifications (controlled\/uncontrolled disease) were estimated using logistic regression.<\/jats:p><jats:p>FEV<jats:sub>0.75<\/jats:sub>\/FVC or FEV<jats:sub>0.5<\/jats:sub>\/FVC ratios &lt;LLN were associated with wheezing disorder (OR 9.78, 95% CI 3.70\u201325.88 and OR 6.64, 95% CI 2.24\u201319.66; all p&lt;0.001). Only an FEV<jats:sub>0.75<\/jats:sub>\/FVC ratio &lt;LLN was associated with uncontrolled wheezing disorder (OR 2.53, 95% CI 1.12\u20135.68; p=0.025).<\/jats:p><jats:p>FEV<jats:sub>0.75<\/jats:sub>\/FVC ratio is a useful surrogate outcome index to evaluate the control of the wheezing disease of preschoolers.<\/jats:p>","DOI":"10.1183\/13993003.01391-2015","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T03:59:06Z","timestamp":1464321546000},"page":"420-427","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Utility of measuring FEV<sub>0.75<\/sub>\/FVC ratio in preschoolers with uncontrolled wheezing disorder"],"prefix":"10.1183","volume":"48","author":[{"given":"V\u00e9ronique","family":"N\u00e8ve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Hulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Edm\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Boileau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Baquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Pouessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Thumerelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Deschildre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Matran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"2024102100042700000_48.2.420.1","unstructured":"NHLBI\/WHO Report. 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