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The secondary end-points were composite response rates after 6\u2005weeks, improvement in lung function, time to first exacerbation, cumulative dose and adverse effects.<\/jats:p><jats:p>92 subjects (high-dose n=44, medium-dose n=48) were included in the study. The numbers of subjects with exacerbation after 1\u2005year (high-dose 40.9%<jats:italic>versus<\/jats:italic>medium-dose 50%, p=0.59) and glucocorticoid-dependent ABPA after 2\u2005years (high-dose 11.4%<jats:italic>versus<\/jats:italic>medium-dose 14.6%, p=0.88) were similar in the two groups. Although composite response rates were significantly higher in the high-dose group, improvement in lung function and time to first exacerbation were similar in the two groups. Cumulative glucocorticoid dose and side-effects were significantly higher in the high-dose group.<\/jats:p><jats:p>Medium-dose oral glucocorticoids are as effective and safer than high-dose in treatment of ABPA.<\/jats:p>","DOI":"10.1183\/13993003.01475-2015","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:06:27Z","timestamp":1448431587000},"page":"490-498","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":138,"title":["A randomised trial of glucocorticoids in acute-stage allergic bronchopulmonary aspergillosis complicating asthma"],"prefix":"10.1183","volume":"47","author":[{"given":"Ritesh","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh N.","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpaul","family":"Singh Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biman","family":"Saikia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digambar","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"2024102023480151000_47.2.490.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2586"},{"key":"2024102023480151000_47.2.490.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"2024102023480151000_47.2.490.3","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206291"},{"key":"2024102023480151000_47.2.490.4","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.738312"},{"key":"2024102023480151000_47.2.490.5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114745"},{"key":"2024102023480151000_47.2.490.6","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-014-9767-z"},{"key":"2024102023480151000_47.2.490.7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.7.4.317"},{"key":"2024102023480151000_47.2.490.8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0808"},{"key":"2024102023480151000_47.2.490.9","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12141"},{"key":"2024102023480151000_47.2.490.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0917"},{"key":"2024102023480151000_47.2.490.11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00139513"},{"key":"2024102023480151000_47.2.490.12","doi-asserted-by":"publisher","DOI":"10.2500\/108854194778816463"},{"key":"2024102023480151000_47.2.490.13","unstructured":"Greenberger PA . 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