{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:28:41Z","timestamp":1781018921798,"version":"3.54.1"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"DOI":"10.13039\/501100000037","name":"Institute of Health Services and Policy Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,11,17]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>There is limited high-quality evidence available to inform the use of text messaging to improve latent tuberculosis infection (LTBI) treatment adherence.<\/jats:p><jats:p>We performed a parallel, randomised controlled trial at two sites to assess the effect of a two-way short message service on LTBI adherence. We enrolled adults initiating LTBI therapy from June 2012 to September 2015 in British Columbia, Canada. Participants were randomised in a 1:1 ratio to standard LTBI treatment (control) or standard LTBI treatment plus two-way weekly text messaging (intervention). The primary outcome was treatment completion, defined as taking \u226580% prescribed doses within 12\u2005months (isoniazid) or 6\u2005months (rifampin) of enrolment. The trial was unblinded except for the data analyst.<\/jats:p><jats:p>A total of 358 participants were assigned to the intervention (n=170) and control (n=188) arms. In intention-to-treat analysis, the proportion of participants completing LTBI therapy in the intervention and control arms was 79.4% and 81.9%, respectively (RR 0.97, 95% CI 0.88\u20131.07; p=0.550). Results were similar for pre-specified secondary end-points, including time-to-completion of LTBI therapy, completion of &gt;90% of prescribed LTBI doses and health-related quality of life.<\/jats:p><jats:p>Weekly two-way text messaging did not improve LTBI completion rates compared to standard LTBI care; however, completion rates were high in both treatment arms.<\/jats:p>","DOI":"10.1183\/13993003.01488-2017","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T10:08:45Z","timestamp":1518084525000},"page":"1701488","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["The effect of text messaging on latent tuberculosis treatment adherence: a randomised controlled trial"],"prefix":"10.1183","volume":"51","author":[{"given":"James C.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia L.","family":"van der Kop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Smillie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawziah","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Sadatsafavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Romanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Budd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hajek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Lester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"2024101909292643000_51.2.1701488.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00214014"},{"key":"2024101909292643000_51.2.1701488.2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01245-2015"},{"key":"2024101909292643000_51.2.1701488.3","unstructured":"World Health Organization. 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