{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:59:13Z","timestamp":1790924353361,"version":"4.1.0"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"name":"OPO Fundation","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/501100013363","name":"Zurich Lung League","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100013363","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,10,21]]},"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>This case\u2013control study evaluates a possible association between high altitude pulmonary hypertension (HAPH) and sleep apnoea in people living at high altitude.<\/jats:p>\n                  <jats:p>Ninety highlanders living at altitudes &gt;2500\u2005m without excessive erythrocytosis and with normal spirometry were studied at 3250\u2005m (Aksay, Kyrgyzstan); 34 healthy lowlanders living below 800\u2005m were studied at 760\u2005m (Bishkek, Kyrgyzstan). Echocardiography, polysomnography and other outcomes were assessed. Thirty-six highlanders with elevated mean pulmonary artery pressure (mPAP) &gt;30\u2005mmHg (31\u201342\u2005mmHg by echocardiography) were designated as HAPH+. Their data were compared to that of 54 healthy highlanders (HH, mPAP 13\u201328\u2005mmHg) and 34 healthy lowlanders (LL,\u00a0mPAP 8\u201324\u2005mmHg).<\/jats:p>\n                  <jats:p>\n                    The HAPH+ group (median age 52\u2005years (interquartile range 47\u201359) had a higher apnoea\u2013hypopnoea index (AHI) of 33.8\u2005events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (26.9\u201354.6) and spent a greater percentage of the night-time with an oxygen saturation &lt;90% (T&lt;90; 78% (61\u201389)) than the HH group (median age 39\u2005years (32\u201348), AHI 9.0\u2005events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (3.6\u201316), T&lt;90 33% (10\u201369)) and the LL group (median age 40\u2005years (30\u201347), AHI 4.3\u2005events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (1.4\u201312.6), T&lt;90 0% (0\u20130)); p&lt;0.007 for AHI and T&lt;90, respectively, in HAPH+\n                    <jats:italic>versus<\/jats:italic>\n                    others. In highlanders, multivariable regression analysis confirmed an independent association between mPAP and both AHI and T&lt;90, when controlled for age, gender and body mass index.\n                  <\/jats:p>\n                  <jats:p>Pulmonary hypertension in highlanders is associated with sleep apnoea and hypoxaemia even when adjusted for age, gender and body mass index, suggesting pathophysiologic interactions between pulmonary haemodynamics and sleep apnoea.<\/jats:p>","DOI":"10.1183\/13993003.01530-2016","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T14:18:58Z","timestamp":1488982738000},"page":"1601530","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Association between sleep apnoea and pulmonary hypertension in Kyrgyz highlanders"],"prefix":"10.1183","volume":"49","author":[{"given":"Tsogyal D.","family":"Latshang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Furian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka S.","family":"Aeschbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batyr","family":"Osmonov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkin M.","family":"Mirrakhimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jainagul","family":"Isakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almaz A.","family":"Aldashev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talant M.","family":"Sooronbaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad E.","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"2024102100174928000_49.2.1601530.1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2005.6.147"},{"key":"2024102100174928000_49.2.1601530.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200204-345OC"},{"key":"2024102100174928000_49.2.1601530.3","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.041954"},{"key":"2024102100174928000_49.2.1601530.4","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2011.1107"},{"key":"2024102100174928000_49.2.1601530.5","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2007.1077"},{"key":"2024102100174928000_49.2.1601530.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00206-8"},{"key":"2024102100174928000_49.2.1601530.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.006977"},{"key":"2024102100174928000_49.2.1601530.8","doi-asserted-by":"publisher","DOI":"10.1038\/nature14620"},{"key":"2024102100174928000_49.2.1601530.9","unstructured":"Ware JE Jr , Snow KK , Kosinski M , et\u00a0al. 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