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Inclusion criteria were severe wheezing, classified as a score of \u22656 points as assessed by the Respiratory Distress Assessment Instrument (RDAI) after initial treatment with salbutamol, and the symptoms of acute viral infection. The children were randomly allocated to receive either an infusion of magnesium sulfate (40\u2005mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) or 0.9% sodium chloride as a placebo infusion for 20\u2005min. Primary outcome measure was mean change in RDAI scores from baseline to 6\u2005h after the treatment.<\/jats:p><jats:p>Change in the severity of wheezing from baseline to 6\u2005h after the treatment, as measured by mean\u00b1<jats:sc>sd<\/jats:sc>RDAI scores, was 4.7\u00b12.6 in the magnesium sulfate group and 4.2\u00b14.2 in the placebo group (difference 0.5, 95% CI \u22121.3 to 2.3, p=0.594).<\/jats:p><jats:p>Intravenous magnesium sulfate was ineffective in treating acute severe virus-induced wheezing in young children, in contrast to the previous efficacy demonstrated in older children.<\/jats:p>","DOI":"10.1183\/13993003.01579-2017","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T10:08:45Z","timestamp":1518084525000},"page":"1701579","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Intravenous magnesium sulfate for acute wheezing in young children: a randomised double-blind trial"],"prefix":"10.1183","volume":"51","author":[{"given":"Hannele","family":"Pruikkonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terhi","family":"Tapiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merja","family":"Kallio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teija","family":"Dunder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tytti","family":"Pokka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Uhari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjo","family":"Renko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"2024101909294259000_51.2.1701579.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04958-8"},{"key":"2024101909294259000_51.2.1701579.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804897"},{"key":"2024101909294259000_51.2.1701579.3","first-page":"CD001266","article-title":"Bronchodilators for bronchiolitis","volume":"6","author":"Gadomski","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2024101909294259000_51.2.1701579.4","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.111060"},{"key":"2024101909294259000_51.2.1701579.5","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.10.979"},{"key":"2024101909294259000_51.2.1701579.6","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-199909000-00005"},{"key":"2024101909294259000_51.2.1701579.7","first-page":"389","article-title":"Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy","volume":"34","author":"Devi","year":"1997","journal-title":"Indian Pediatr"},{"key":"2024101909294259000_51.2.1701579.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70023-9"},{"key":"2024101909294259000_51.2.1701579.9","first-page":"CD011050","article-title":"Intravenous magnesium sulfate for treating children with acute asthma in the emergency department","volume":"4","author":"Griffiths","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2024101909294259000_51.2.1701579.10","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/apa.12780","article-title":"Randomised comparison of intravenous magnesium sulphate, terbutaline and aminophylline for children with acute severe asthma","volume":"103","author":"Singhi","year":"2014","journal-title":"Acta Paediatr"},{"key":"2024101909294259000_51.2.1701579.11","first-page":"291","article-title":"Effectiveness of magnesium sulfate as initial treatment of acute severe asthma in children, conducted in a tertiary-level university hospital: A randomized, controlled trial","volume":"110","author":"Torres","year":"2012","journal-title":"Arch Argent Pediatr"},{"key":"2024101909294259000_51.2.1701579.12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380110065013"},{"key":"2024101909294259000_51.2.1701579.13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.79.6.939","article-title":"Wheezing in infants: The response to epinephrine","volume":"79","author":"Lowell","year":"1987","journal-title":"Pediatrics"},{"key":"2024101909294259000_51.2.1701579.14","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20845"},{"key":"2024101909294259000_51.2.1701579.15","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.1.76"},{"key":"2024101909294259000_51.2.1701579.16","unstructured":"StatsDirect ltd. 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