{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:37:44Z","timestamp":1770903464024,"version":"3.50.1"},"reference-count":18,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,1,14]]},"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Pulmonary arteriovenous malformations (PAVMs) are associated with severe neurological complications in hereditary haemorrhagic telangiectasia (HHT). Transthoracic contrast echocardiography (TTCE) is recommended for screening of pulmonary right-to-left shunts (RLS). Although growth of PAVMs is shown in two small studies, no studies on follow-up with TTCE exist.<\/jats:p><jats:p>All HHT patients underwent a second TTCE 5\u2005years after initial screening. Patients with a history of PAVM embolisation were excluded. Pulmonary RLS grade on TTCE after 5\u2005years was compared to the grade at screening.<\/jats:p><jats:p>200 patients (53.5% female, mean\u00b1<jats:sc>sd<\/jats:sc>age at screening 44.7\u00b114.1\u2005years) were included. Increase in RLS grade occurred in 36 (18%) patients, of whom six (17%) underwent embolisation. The change in grade between screening and follow-up was not more than one grade. Of patients with nontreatable pulmonary RLS at screening (n=113), 14 (12.4%) underwent embolisation. In patients without pulmonary RLS at initial screening (n=87), no treatable PAVMs developed during follow-up.<\/jats:p><jats:p>Within 5\u2005years, no treatable PAVMs developed in HHT patients without pulmonary RLS at initial screening. Increase in pulmonary RLS grade occurred in 18% of patients, and never increased by more than one grade. Of patients with nontreatable pulmonary RLS at initial screening, 12% underwent embolisation.<\/jats:p>","DOI":"10.1183\/13993003.01588-2015","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T04:03:13Z","timestamp":1457668993000},"page":"1750-1757","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Follow-up of pulmonary right-to-left shunt in hereditary haemorrhagic telangiectasia"],"prefix":"10.1183","volume":"47","author":[{"given":"Veronique M.M.","family":"Vorselaars","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan","family":"Velthuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Repke J.","family":"Snijder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis J.J.","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes J.","family":"Mager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn C.","family":"Post","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"2024102023562699000_47.6.1750.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1599"},{"key":"2024102023562699000_47.6.1750.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.2.9711041"},{"key":"2024102023562699000_47.6.1750.3","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.069013"},{"key":"2024102023562699000_47.6.1750.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201407-1254CI"},{"key":"2024102023562699000_47.6.1750.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510053331407"},{"key":"2024102023562699000_47.6.1750.6","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-345"},{"key":"2024102023562699000_47.6.1750.7","doi-asserted-by":"publisher","DOI":"10.1086\/513903"},{"key":"2024102023562699000_47.6.1750.8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1849"},{"key":"2024102023562699000_47.6.1750.9","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000126811.05229.B6"},{"key":"2024102023562699000_47.6.1750.10","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000191410.13974.B6"},{"key":"2024102023562699000_47.6.1750.11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00049008"},{"key":"2024102023562699000_47.6.1750.12","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen317"},{"key":"2024102023562699000_47.6.1750.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00133713"},{"key":"2024102023562699000_47.6.1750.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.12.008"},{"key":"2024102023562699000_47.6.1750.15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2356"},{"key":"2024102023562699000_47.6.1750.16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200310-1441OC"},{"key":"2024102023562699000_47.6.1750.17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00104309"},{"key":"2024102023562699000_47.6.1750.18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.2.351"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01588-2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:31:32Z","timestamp":1740378692000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01588-2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,10]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,5,31]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1183\/13993003.01588-2015"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01588-2015","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,10]]}}}