{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:40:07Z","timestamp":1791549607371,"version":"4.3.4"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,2,24]]},"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Angiogenesis is a crucial factor in the progression of malignant pleural mesothelioma (MPM) and antiangiogenic strategies might be effective against MPM. Aminopeptidase N (APN)\/CD13 promotes tumour angiogenesis and is associated with poor prognosis; however, its clinical significance in MPM remains unclear.<\/jats:p><jats:p>In 37 consecutive patients with surgically resected MPM, we evaluated the association between immunohistochemical APN\/CD13 expression in resected tumours and survival. Additionally, the antitumour and antiangiogenic effects of MT95-4, a fully humanised anti-APN\/CD13 monoclonal antibody, were evaluated in mice orthotopically implanted with EHMES-10 (abundantly expressing APN\/CD13) and MSTO-211H (scarcely expressing APN\/CD13) MPM cells.<\/jats:p><jats:p>High tumour APN\/CD13 expression was associated with poor prognosis in MPM patients (p=0.04), and MT95-4 treatment reduced tumour growth and angiogenesis in mice harbouring EHMES-10 but not MSTO-211H cells. Furthermore, in mice harbouring EHMES-10 cells, MT95-4 combined with cisplatin more effectively suppressed tumour progression than cisplatin alone.<\/jats:p><jats:p>Taken together, these results suggest that APN\/CD13 is implicated in the aggressiveness of MPM. Here, MT95-4 treatment reduced tumour progression likely by inhibiting angiogenesis, suggesting APN\/CD13 as a potential molecular target for MPM treatment. Additionally, combination treatment with MT95-4 and cisplatin could represent a promising approach to treating MPM exhibiting high APN\/CD13 expression.<\/jats:p>","DOI":"10.1183\/13993003.01610-2017","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T01:10:15Z","timestamp":1520557815000},"page":"1701610","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Aminopeptidase N\/CD13 as a potential therapeutic target in malignant pleural 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