{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:43:27Z","timestamp":1790059407862,"version":"4.0.1"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,10,13]]},"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>The COPD Patient Management European Trial (COMET) investigated the efficacy and safety of a home-based COPD disease management intervention for severe COPD patients.<\/jats:p><jats:p>The study was an international open-design clinical trial in COPD patients (forced expiratory volume in 1 s &lt;50% of predicted value) randomised 1:1 to the disease management intervention or to the usual management practices at the study centre. The disease management intervention included a self-management programme, home telemonitoring, care coordination and medical management. The primary end-point was the number of unplanned all-cause hospitalisation days in the intention-to-treat (ITT) population. Secondary end-points included acute care hospitalisation days, BODE (body mass index, airflow obstruction, dyspnoea and exercise) index and exacerbations. Safety end-points included adverse events and deaths.<\/jats:p><jats:p>For the 157 (disease management) and 162 (usual management) patients eligible for ITT analyses, all-cause hospitalisation days per year (mean\u00b1<jats:sc>sd<\/jats:sc>) were 17.4\u00b135.4 and 22.6\u00b141.8, respectively (mean difference \u22125.3, 95% CI \u221213.7 to \u22123.1; p=0.16). The disease management group had fewer per-protocol acute care hospitalisation days per year (p=0.047), a lower BODE index (p=0.01) and a lower mortality rate (1.9%<jats:italic>versus<\/jats:italic>14.2%; p&lt;0.001), with no difference in exacerbation frequency. Patient profiles and hospitalisation practices varied substantially across countries.<\/jats:p><jats:p>The COMET disease management intervention did not significantly reduce unplanned all-cause hospitalisation days, but reduced acute care hospitalisation days and mortality in severe COPD patients.<\/jats:p>","DOI":"10.1183\/13993003.01612-2017","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T01:11:18Z","timestamp":1515719478000},"page":"1701612","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":81,"title":["COMET: a multicomponent home-based disease-management programme<i>versus<\/i>routine care in severe 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