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We used data from the HypnoLaus study to assess associations between OSA and longitudinal cognitive changes in a sample of community-dwelling elderly individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied associations between polysomnographic OSA parameters (of breathing\/hypoxaemia and sleep fragmentation) and cognitive changes over a 5-year period, after adjustment for potential confounders. The primary outcome was the annual change in cognitive scores. The moderating effects of age, sex and apolipoprotein E4 (ApoE4) status were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>358 elderly individuals without dementia were included (mean\u00b1<jats:sc>sd<\/jats:sc>age 71.0\u00b14.2\u2005years; 42.5% males). A lower mean peripheral oxygen saturation (<jats:italic>S<\/jats:italic><jats:sub>pO<jats:sub>2<\/jats:sub><\/jats:sub>) during sleep was associated with a steeper decline in Mini-Mental State Examination (<jats:italic>B<\/jats:italic>=\u2009\u22120.12, p=0.004), Stroop test condition 1 (<jats:italic>B<\/jats:italic>=0.53, p=0.002) and Free and Cued Selective Reminding Test delayed free recall (<jats:italic>B<\/jats:italic>=\u2009\u22120.05, p=0.008). A longer time spent asleep with<jats:italic>S<\/jats:italic><jats:sub>pO<jats:sub>2<\/jats:sub><\/jats:sub>&lt;90% was associated with a steeper decline in Stroop test condition 1 (<jats:italic>B<\/jats:italic>=0.47, p=0.006). Moderation analysis showed that apnoea\u2013hypopnoea index and oxygen desaturation index were associated with a steeper decline in global cognitive function, processing speed and executive function only in older participants, men and ApoE4 carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results provide evidence of the contribution of OSA and nocturnal hypoxaemia to cognitive decline in the elderly population.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.01621-2022","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T13:40:16Z","timestamp":1676554816000},"page":"2201621","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":88,"title":["Obstructive sleep apnoea and 5-year cognitive decline in the elderly"],"prefix":"10.1183","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-4399","authenticated-orcid":false,"given":"Nicola Andrea","family":"Marchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-133X","authenticated-orcid":false,"given":"Geoffroy","family":"Solelhac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6415-7694","authenticated-orcid":false,"given":"Mathieu","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-6436","authenticated-orcid":false,"given":"Jos\u00e9","family":"Haba-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Gosselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-896X","authenticated-orcid":false,"given":"Peter","family":"Vollenweider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-8500","authenticated-orcid":false,"given":"Pedro","family":"Marques-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-0312","authenticated-orcid":false,"given":"Julius","family":"Popp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-3803","authenticated-orcid":false,"given":"Armin","family":"von Gunten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-4259","authenticated-orcid":false,"given":"Martin","family":"Preisig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5159-5919","authenticated-orcid":false,"given":"Bogdan","family":"Draganski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-7788","authenticated-orcid":false,"given":"Raphael","family":"Heinzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"2024102103120306000_61.4.2201621.1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2024102103120306000_61.4.2201621.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.101250"},{"key":"2024102103120306000_61.4.2201621.3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11065-017-9344-6","article-title":"is obstructive sleep apnoea related to neuropsychological function in healthy older adults? 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