{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:53:57Z","timestamp":1791338037831,"version":"4.3.1"},"reference-count":149,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2024,5,29]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>The clinical classification of pulmonary hypertension (PH) has guided diagnosis and treatment of patients with PH for several decades. Discoveries relating to underlying mechanisms, pathobiology and responses to treatments for PH have informed the evolution in this clinical classification to describe the heterogeneity in PH phenotypes. In more recent years, advances in imaging, computational science and multi-omic approaches have yielded new insights into potential phenotypes and sub-phenotypes within the existing clinical classification. Identification of novel phenotypes in pulmonary arterial hypertension (PAH) with unique molecular profiles, for example, could lead to new precision therapies. Recent phenotyping studies have also identified groups of patients with PAH that more closely resemble patients with left heart disease (group 2 PH) and lung disease (group 3 PH), which has important prognostic and therapeutic implications. Within group 2 and group 3 PH, novel phenotypes have emerged that reflect a persistent and severe pulmonary vasculopathy that is associated with worse prognosis but still distinct from PAH. In group 4 PH (chronic thromboembolic pulmonary disease) and sarcoidosis (group 5 PH), the current approach to patient phenotyping integrates clinical, haemodynamic and imaging characteristics to guide treatment but applications of multi-omic approaches to sub-phenotyping in these areas are sparse. The next iterations of the PH clinical classification are likely to reflect several emerging PH phenotypes and improve the next generation of prognostication tools and clinical trial design, and improve treatment selection in clinical practice.<\/jats:p>","DOI":"10.1183\/13993003.01633-2023","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T10:50:15Z","timestamp":1720090215000},"page":"2301633","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Phenotypes in pulmonary hypertension"],"prefix":"10.1183","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0615-4575","authenticated-orcid":false,"given":"Jason","family":"Weatherald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Hemnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Mielniczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-0996","authenticated-orcid":false,"given":"Christian","family":"Gerges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-660X","authenticated-orcid":false,"given":"Laura C.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-2293","authenticated-orcid":false,"given":"Marius M.","family":"Hoeper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-2892","authenticated-orcid":false,"given":"Marc","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"2024102103314770000_64.3.2301633.1","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1172\/JCI124611","article-title":"Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases","volume":"129","author":"Agache","year":"2019","journal-title":"J Clin Invest"},{"key":"2024102103314770000_64.3.2301633.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-1954ST"},{"key":"2024102103314770000_64.3.2301633.3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01359-2015"},{"key":"2024102103314770000_64.3.2301633.4","unstructured":"Hatano S , Strasser T . Primary Pulmonary Hypertension: Report on a WHO Meeting. Geneva, World Health Organization, 1973. Available from: https:\/\/apps.who.int\/iris\/handle\/10665\/39094"},{"key":"2024102103314770000_64.3.2301633.5","first-page":"2200879","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Respir J"},{"key":"2024102103314770000_64.3.2301633.6","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"2024102103314770000_64.3.2301633.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311737"},{"key":"2024102103314770000_64.3.2301633.8","doi-asserted-by":"crossref","first-page":"e010555","DOI":"10.1161\/CIRCHEARTFAILURE.123.010555","article-title":"Classification and predictors of right ventricular functional recovery in pulmonary arterial hypertension","volume":"16","author":"Rischard","year":"2023","journal-title":"Circ Heart Fail"},{"key":"2024102103314770000_64.3.2301633.9","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.jchf.2023.03.003","article-title":"Shedding light on latent pulmonary vascular disease in heart failure with preserved ejection fraction","volume":"11","author":"Caravita","year":"2023","journal-title":"JACC Heart Fail"},{"key":"2024102103314770000_64.3.2301633.10","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.healun.2019.12.012","article-title":"Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis","volume":"39","author":"Badagliacca","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ehf2.14216","article-title":"Dynamic aspects of ventricular interaction during exercise in HFpEF and in pre-capillary pulmonary hypertension","volume":"10","author":"Claeys","year":"2023","journal-title":"ESC Heart Fail"},{"key":"2024102103314770000_64.3.2301633.12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0150"},{"key":"2024102103314770000_64.3.2301633.13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/clc.22968","article-title":"Harnessing mHealth technologies to increase physical activity and prevent cardiovascular disease","volume":"41","author":"Feldman","year":"2018","journal-title":"Clin Cardiol"},{"key":"2024102103314770000_64.3.2301633.14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026184"},{"key":"2024102103314770000_64.3.2301633.15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1164\/rccm.201303-0467LE","article-title":"A proof of concept for the detection and classification of pulmonary arterial hypertension through breath analysis with a sensor array","volume":"188","author":"Cohen-Kaminsky","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102103314770000_64.3.2301633.16","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/CIRCRESAHA.121.319969","article-title":"Harnessing big data to advance treatment and understanding of pulmonary hypertension","volume":"130","author":"Rhodes","year":"2022","journal-title":"Circ Res"},{"key":"2024102103314770000_64.3.2301633.17","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/CIRCRESAHA.118.313911","article-title":"Discovery of distinct immune phenotypes using machine learning in pulmonary arterial hypertension","volume":"124","author":"Sweatt","year":"2019","journal-title":"Circ Res"},{"key":"2024102103314770000_64.3.2301633.18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1164\/rccm.202108-1919OC","article-title":"Autoimmunity is a significant feature of idiopathic pulmonary arterial hypertension","volume":"206","author":"Jones","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102103314770000_64.3.2301633.19","doi-asserted-by":"crossref","first-page":"e001887","DOI":"10.1161\/CIRCGEN.117.001887","article-title":"Exome sequencing in children with pulmonary arterial hypertension demonstrates differences compared with adults","volume":"11","author":"Zhu","year":"2018","journal-title":"Circ Genom Precis Med"},{"key":"2024102103314770000_64.3.2301633.20","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02340-2019"},{"key":"2024102103314770000_64.3.2301633.21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00585-2020"},{"key":"2024102103314770000_64.3.2301633.22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129203"},{"key":"2024102103314770000_64.3.2301633.23","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0093-2017"},{"key":"2024102103314770000_64.3.2301633.24","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1164\/rccm.202109-2106OC","article-title":"Mining the plasma proteome for insights into the molecular pathology of pulmonary arterial hypertension","volume":"205","author":"Harbaum","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102103314770000_64.3.2301633.25","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41598-023-27435-4","article-title":"Identification of diagnostic biomarkers for idiopathic pulmonary hypertension with metabolic syndrome by bioinformatics and machine learning","volume":"13","author":"Lu","year":"2023","journal-title":"Sci Rep"},{"key":"2024102103314770000_64.3.2301633.26","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00484-2022"},{"key":"2024102103314770000_64.3.2301633.27","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1177\/2045893217705891","article-title":"Novel approach to classifying patients with pulmonary arterial hypertension using cluster analysis","volume":"7","author":"Parikh","year":"2017","journal-title":"Pulm Circ"},{"key":"2024102103314770000_64.3.2301633.28","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aap7294"},{"key":"2024102103314770000_64.3.2301633.29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.healun.2019.12.002","article-title":"Circulating NEDD9 is increased in pulmonary arterial hypertension: a multicenter, retrospective analysis","volume":"39","author":"Samokhin","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.30","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/psp4.12670","article-title":"Network module-based drug repositioning for pulmonary arterial hypertension","volume":"10","author":"Wang","year":"2021","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"2024102103314770000_64.3.2301633.31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.healun.2020.11.001","article-title":"Multidimensional assessment and cluster analysis for idiopathic pulmonary arterial hypertension phenotyping","volume":"40","author":"Badagliacca","year":"2021","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.32","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/S0140-6736(22)01601-4","article-title":"The evolving landscape of pulmonary arterial hypertension clinical trials","volume":"400","author":"Weatherald","year":"2022","journal-title":"Lancet"},{"key":"2024102103314770000_64.3.2301633.33","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"2024102103314770000_64.3.2301633.34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024277"},{"key":"2024102103314770000_64.3.2301633.35","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jacc.2021.07.057","article-title":"Three- versus two-drug therapy for patients with newly diagnosed pulmonary arterial hypertension","volume":"78","author":"Chin","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2024102103314770000_64.3.2301633.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.10.026"},{"key":"2024102103314770000_64.3.2301633.37","doi-asserted-by":"crossref","first-page":"2101552","DOI":"10.1183\/13993003.01552-2021","article-title":"Mortality trends in pulmonary arterial hypertension in Canada: a temporal analysis of survival per ESC\/ERS guideline era","volume":"59","author":"Zelt","year":"2021","journal-title":"Eur Respir J"},{"key":"2024102103314770000_64.3.2301633.38","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202009-3698OC"},{"key":"2024102103314770000_64.3.2301633.39","doi-asserted-by":"crossref","first-page":"2102024","DOI":"10.1183\/13993003.02024-2021","article-title":"Temporal trends in pulmonary arterial hypertension: results from the COMPERA registry","volume":"59","author":"Hoeper","year":"2021","journal-title":"Eur Respir J"},{"key":"2024102103314770000_64.3.2301633.40","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1900"},{"key":"2024102103314770000_64.3.2301633.41","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00789-2016"},{"key":"2024102103314770000_64.3.2301633.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.05.038"},{"key":"2024102103314770000_64.3.2301633.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.047"},{"key":"2024102103314770000_64.3.2301633.44","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.healun.2020.09.011","article-title":"Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry","volume":"39","author":"Hoeper","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.45","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.healun.2022.05.007","article-title":"Idiopathic pulmonary arterial hypertension patients with a high H2FPEF-score: insights from the Amsterdam UMC PAH-cohort","volume":"41","author":"Kianzad","year":"2022","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.05.014"},{"key":"2024102103314770000_64.3.2301633.47","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01897-2018"},{"key":"2024102103314770000_64.3.2301633.48","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.930701"},{"key":"2024102103314770000_64.3.2301633.49","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1164\/rccm.202306-1072OC","article-title":"Implications of mean pulmonary arterial wedge pressure trajectories in pulmonary arterial hypertension","volume":"209","author":"Harder","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102103314770000_64.3.2301633.50","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1016\/j.jacc.2020.10.007","article-title":"Cardiopulmonary hemodynamics in pulmonary hypertension and heart failure: JACC review topic of the week","volume":"76","author":"Maron","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2024102103314770000_64.3.2301633.51","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034646"},{"key":"2024102103314770000_64.3.2301633.52","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S2213-2600(22)00097-2","article-title":"Phenotyping of idiopathic pulmonary arterial hypertension: a registry analysis","volume":"10","author":"Hoeper","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2024102103314770000_64.3.2301633.53","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00184412"},{"key":"2024102103314770000_64.3.2301633.54","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00041-2020"},{"key":"2024102103314770000_64.3.2301633.55","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01914-2018"},{"key":"2024102103314770000_64.3.2301633.56","doi-asserted-by":"crossref","first-page":"e0197112","DOI":"10.1371\/journal.pone.0197112","article-title":"Clinical phenotypes and survival of pre-capillary pulmonary hypertension in systemic sclerosis","volume":"13","author":"Launay","year":"2018","journal-title":"PLoS One"},{"key":"2024102103314770000_64.3.2301633.57","first-page":"1986","article-title":"The clinical implications of left ventricular diastolic dysfunction in systemic sclerosis","volume":"40","author":"Ross","year":"2022","journal-title":"Clin Exp Rheumatol"},{"key":"2024102103314770000_64.3.2301633.58","doi-asserted-by":"crossref","first-page":"1702310","DOI":"10.1183\/13993003.02310-2017","article-title":"Impact of age and comorbidity on risk stratification in idiopathic pulmonary arterial hypertension","volume":"51","author":"Hjalmarsson","year":"2018","journal-title":"Eur Respir J"},{"key":"2024102103314770000_64.3.2301633.59","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.healun.2022.10.003","article-title":"Risk stratification and response to therapy in patients with pulmonary arterial hypertension and comorbidities: a COMPERA analysis","volume":"42","author":"Rosenkranz","year":"2023","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.60","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.healun.2019.09.010","article-title":"Patients with pulmonary arterial hypertension with and without cardiovascular risk factors: results from the AMBITION trial","volume":"38","author":"McLaughlin","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.61","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1.182"},{"key":"2024102103314770000_64.3.2301633.62","doi-asserted-by":"publisher","DOI":"10.1002\/art.23303"},{"key":"2024102103314770000_64.3.2301633.63","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev097"},{"key":"2024102103314770000_64.3.2301633.64","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01899-2018"},{"key":"2024102103314770000_64.3.2301633.65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S2213-2600(15)00544-5","article-title":"BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis","volume":"4","author":"Evans","year":"2016","journal-title":"Lancet Respir Med"},{"key":"2024102103314770000_64.3.2301633.66","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00464-2016"},{"key":"2024102103314770000_64.3.2301633.67","doi-asserted-by":"crossref","first-page":"e222488","DOI":"10.1148\/radiol.222488","article-title":"Imaging features in BMPR2 mutation-associated pulmonary arterial hypertension","volume":"307","author":"Zhao","year":"2023","journal-title":"Radiology"},{"key":"2024102103314770000_64.3.2301633.68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S2213-2600(16)30438-6","article-title":"Clinical phenotypes and outcomes of heritable and sporadic pulmonary veno-occlusive disease: a population-based study","volume":"5","author":"Montani","year":"2017","journal-title":"Lancet Respir Med"},{"key":"2024102103314770000_64.3.2301633.69","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028351"},{"key":"2024102103314770000_64.3.2301633.70","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201906-1141OC"},{"key":"2024102103314770000_64.3.2301633.71","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108023450503"},{"key":"2024102103314770000_64.3.2301633.72","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01634-2023"},{"key":"2024102103314770000_64.3.2301633.73","doi-asserted-by":"crossref","first-page":"e0184227","DOI":"10.1371\/journal.pone.0184227","article-title":"Pulmonary hypertension subtypes associated with hereditary haemorrhagic telangiectasia: haemodynamic profiles and survival probability","volume":"12","author":"Revuz","year":"2017","journal-title":"PLoS One"},{"key":"2024102103314770000_64.3.2301633.74","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01197-2022"},{"key":"2024102103314770000_64.3.2301633.75","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1164\/rccm.202203-0485OC","article-title":"First genotype-phenotype study in TBX4 syndrome: gain-of-function mutations causative for lung disease","volume":"206","author":"Prapa","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102103314770000_64.3.2301633.76","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00656-2022"},{"key":"2024102103314770000_64.3.2301633.77","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01232-2022"},{"key":"2024102103314770000_64.3.2301633.78","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202105-1118OC"},{"key":"2024102103314770000_64.3.2301633.79","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020207"},{"key":"2024102103314770000_64.3.2301633.80","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S2213-2600(20)30317-9","article-title":"Pulmonary vascular resistance and clinical outcomes in patients with pulmonary hypertension: a retrospective cohort study","volume":"8","author":"Maron","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2024102103314770000_64.3.2301633.81","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv512"},{"key":"2024102103314770000_64.3.2301633.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.942"},{"key":"2024102103314770000_64.3.2301633.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.069"},{"key":"2024102103314770000_64.3.2301633.84","doi-asserted-by":"crossref","first-page":"e028121","DOI":"10.1161\/JAHA.122.028121","article-title":"Biomechanical and mechanobiological drivers of the transition from postcapillary pulmonary hypertension to combined pre-\/postcapillary pulmonary hypertension","volume":"12","author":"Allen","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2024102103314770000_64.3.2301633.85","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031608"},{"key":"2024102103314770000_64.3.2301633.86","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02280-2023"},{"key":"2024102103314770000_64.3.2301633.87","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1513\/AnnalsATS.202303-216OC","article-title":"Impact on pulmonary hypertension hemodynamic classification based on the methodology used to measure pulmonary artery wedge pressure and cardiac output","volume":"20","author":"Sahay","year":"2023","journal-title":"Ann Am Thorac Soc"},{"key":"2024102103314770000_64.3.2301633.88","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.chest.2018.08.1033","article-title":"Features associated with discordance between pulmonary arterial wedge pressure and left ventricular end diastolic pressure in clinical practice: implications for pulmonary hypertension classification","volume":"154","author":"Hemnes","year":"2018","journal-title":"Chest"},{"key":"2024102103314770000_64.3.2301633.89","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2784"},{"key":"2024102103314770000_64.3.2301633.90","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00209313"},{"key":"2024102103314770000_64.3.2301633.91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.02.015"},{"key":"2024102103314770000_64.3.2301633.92","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01886-2017"},{"key":"2024102103314770000_64.3.2301633.93","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.chest.2022.09.040","article-title":"Evidence of advanced pulmonary vascular remodeling in obstructive hypertrophic cardiomyopathy with pulmonary hypertension","volume":"163","author":"Maron","year":"2023","journal-title":"Chest"},{"key":"2024102103314770000_64.3.2301633.94","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht537"},{"key":"2024102103314770000_64.3.2301633.95","first-page":"I162","article-title":"Mitral valve replacement after closed mitral commissurotomy","volume":"66","author":"Rutledge","year":"1982","journal-title":"Circulation"},{"key":"2024102103314770000_64.3.2301633.96","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/eurheartj\/ehx700","article-title":"Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial","volume":"39","author":"Bermejo","year":"2018","journal-title":"Eur Heart J"},{"key":"2024102103314770000_64.3.2301633.97","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00186.2013"},{"key":"2024102103314770000_64.3.2301633.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.035"},{"key":"2024102103314770000_64.3.2301633.99","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00245902"},{"key":"2024102103314770000_64.3.2301633.100","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1233OC"},{"key":"2024102103314770000_64.3.2301633.101","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201401-0037OC"},{"key":"2024102103314770000_64.3.2301633.102","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.ajpath.2020.03.008","article-title":"Molecular profiling of vascular remodeling in chronic pulmonary disease","volume":"190","author":"Neubert","year":"2020","journal-title":"Am J Pathol"},{"key":"2024102103314770000_64.3.2301633.103","doi-asserted-by":"crossref","first-page":"e12006","DOI":"10.1002\/pul2.12006","article-title":"Clinical insights into pulmonary hypertension in chronic obstructive pulmonary disease","volume":"12","author":"Cook","year":"2022","journal-title":"Pulm Circ"},{"key":"2024102103314770000_64.3.2301633.104","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201408-1423OC"},{"key":"2024102103314770000_64.3.2301633.105","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1531"},{"key":"2024102103314770000_64.3.2301633.106","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-006OC"},{"key":"2024102103314770000_64.3.2301633.107","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00079512"},{"key":"2024102103314770000_64.3.2301633.108","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.healun.2021.04.021","article-title":"Severe pulmonary hypertension associated with chronic obstructive pulmonary disease: a prospective French multicenter cohort","volume":"40","author":"Dauriat","year":"2021","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.109","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1164\/rccm.201801-0095PP","article-title":"Pulmonary vascular involvement in chronic obstructive pulmonary disease. Is there a pulmonary vascular phenotype?","volume":"198","author":"Kovacs","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102103314770000_64.3.2301633.110","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00944-2021"},{"key":"2024102103314770000_64.3.2301633.111","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chest.2019.02.333","article-title":"Pulmonary arterial histologic lesions in patients with COPD with severe pulmonary hypertension","volume":"156","author":"Bunel","year":"2019","journal-title":"Chest"},{"key":"2024102103314770000_64.3.2301633.112","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/2045893217709762","article-title":"Pulmonary venous remodeling in COPD-pulmonary hypertension and idiopathic pulmonary arterial hypertension","volume":"7","author":"Andersen","year":"2017","journal-title":"Pulm Circ"},{"key":"2024102103314770000_64.3.2301633.113","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207696"},{"key":"2024102103314770000_64.3.2301633.114","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00370-2019"},{"key":"2024102103314770000_64.3.2301633.115","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1164\/rccm.201811-2063OC","article-title":"Arterial vascular pruning, right ventricular size, and clinical outcomes in chronic obstructive pulmonary disease. A longitudinal observational study","volume":"200","author":"Washko","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102103314770000_64.3.2301633.116","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0173-2022"},{"key":"2024102103314770000_64.3.2301633.117","doi-asserted-by":"crossref","first-page":"e12213","DOI":"10.1002\/pul2.12213","article-title":"Pathogenesis, clinical features, and phenotypes of pulmonary hypertension associated with interstitial lung disease: a consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative - Group 3 Pulmonary Hypertension","volume":"13","author":"Piccari","year":"2023","journal-title":"Pulm Circ"},{"key":"2024102103314770000_64.3.2301633.118","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.3.746"},{"key":"2024102103314770000_64.3.2301633.119","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1159\/000524263","article-title":"The effect of borderline pulmonary hypertension on survival in chronic lung disease","volume":"101","author":"Piccari","year":"2022","journal-title":"Respiration"},{"key":"2024102103314770000_64.3.2301633.120","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01537-2014"},{"key":"2024102103314770000_64.3.2301633.121","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01483-2021"},{"key":"2024102103314770000_64.3.2301633.122","first-page":"Suppl. 109\u2013","article-title":"Pulmonary hypertension and interstitial lung disease within PHAROS: impact of extent of fibrosis and pulmonary physiology on cardiac haemodynamic parameters","volume":"32","author":"Fischer","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"2024102103314770000_64.3.2301633.123","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0116"},{"key":"2024102103314770000_64.3.2301633.124","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00021005"},{"key":"2024102103314770000_64.3.2301633.125","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00038709"},{"key":"2024102103314770000_64.3.2301633.126","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12890-016-0300-7","article-title":"Combined pulmonary fibrosis and emphysema: a retrospective analysis of clinical characteristics, treatment and prognosis","volume":"16","author":"Zhang","year":"2016","journal-title":"BMC Pulm Med"},{"key":"2024102103314770000_64.3.2301633.127","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.healun.2021.02.006","article-title":"Impact of lung morphology on clinical outcomes with riociguat in patients with pulmonary hypertension and idiopathic interstitial pneumonia: a post hoc subgroup analysis of the RISE-IIP study","volume":"40","author":"Nathan","year":"2021","journal-title":"J Heart Lung Transplant"},{"key":"2024102103314770000_64.3.2301633.128","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008470"},{"key":"2024102103314770000_64.3.2301633.129","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1164\/rccm.202107-1766OC","article-title":"Efficacy of inhaled treprostinil on multiple disease progression events in patients with pulmonary hypertension due to parenchymal lung disease in the INCREASE trial","volume":"205","author":"Nathan","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102103314770000_64.3.2301633.130","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0449"},{"key":"2024102103314770000_64.3.2301633.131","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00142.2016"},{"key":"2024102103314770000_64.3.2301633.132","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2174OC"},{"key":"2024102103314770000_64.3.2301633.133","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/01902148.2021.2024301","article-title":"Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor \u03b2-induced profibrotic responses in lung fibroblasts","volume":"48","author":"Fukihara","year":"2022","journal-title":"Exp Lung Res"},{"key":"2024102103314770000_64.3.2301633.134","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02828-2020"},{"key":"2024102103314770000_64.3.2301633.135","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01915-2018"},{"key":"2024102103314770000_64.3.2301633.136","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.3.685"},{"key":"2024102103314770000_64.3.2301633.137","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00169113"},{"key":"2024102103314770000_64.3.2301633.138","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041515"},{"key":"2024102103314770000_64.3.2301633.139","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00828-2"},{"key":"2024102103314770000_64.3.2301633.140","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003318"},{"key":"2024102103314770000_64.3.2301633.141","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.chest.2018.03.059","article-title":"Poor subpleural perfusion predicts failure after balloon pulmonary angioplasty for nonoperable chronic thromboembolic pulmonary hypertension","volume":"154","author":"Taniguchi","year":"2018","journal-title":"Chest"},{"key":"2024102103314770000_64.3.2301633.142","doi-asserted-by":"publisher","DOI":"10.1378\/chest.81.2.151"},{"key":"2024102103314770000_64.3.2301633.143","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.024"},{"key":"2024102103314770000_64.3.2301633.144","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111841.28126.D4"},{"key":"2024102103314770000_64.3.2301633.145","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jacc.2022.11.049","article-title":"Left ventricular filling pressure in chronic thromboembolic pulmonary hypertension","volume":"81","author":"Gerges","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2024102103314770000_64.3.2301633.146","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.042838"},{"key":"2024102103314770000_64.3.2301633.147","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0165-2021"},{"key":"2024102103314770000_64.3.2301633.148","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/MCP.0000000000000793","article-title":"Sarcoidosis associated pulmonary hypertension: an update","volume":"27","author":"Samaranayake","year":"2021","journal-title":"Curr Opin Pulm Med"},{"key":"2024102103314770000_64.3.2301633.149","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2007.12.006"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01633-2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T02:21:23Z","timestamp":1740363683000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01633-2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":149,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9,5]]},"published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1183\/13993003.01633-2023"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01633-2023","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,4]]}}}