{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:08:23Z","timestamp":1792706903675,"version":"4.5.0"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL13890"],"award-info":[{"award-number":["K23HL13890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR001103"],"award-info":[{"award-number":["KL2TR001103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR001870"],"award-info":[{"award-number":["KL2TR001870"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL09309"],"award-info":[{"award-number":["R01HL09309"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130796"],"award-info":[{"award-number":["R01HL130796"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,12,27]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    Leukocyte telomere length (LTL),\n                    <jats:italic>MUC5B<\/jats:italic>\n                    rs35705950 and\n                    <jats:italic>TOLLIP<\/jats:italic>\n                    rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF).\n                  <\/jats:p>\n                  <jats:p>In this observational cohort study, we assessed the associations between these genomic markers and outcomes of survival and rate of disease progression in patients with interstitial pneumonia with autoimmune features (IPAF, n=250) and connective tissue disease-associated interstitial lung disease (CTD-ILD, n=248). IPF (n=499) was used as a comparator.<\/jats:p>\n                  <jats:p>\n                    The\u00a0LTL of IPAF and CTD-ILD patients (mean age-adjusted log-transformed T\/S of \u22120.05\u00b10.29 and\u00a0\u22120.04\u00b10.25, respectively) is longer than that of IPF patients (\u22120.17\u00b10.32). For IPAF patients, LTL &lt;10th percentile is associated with faster lung function decline compared to LTL \u226510th percentile (\u22126.43% per year\n                    <jats:italic>versus<\/jats:italic>\n                    \u22120.86% per year; p&lt;0.0001) and worse transplant-free survival (hazard ratio 2.97, 95% CI 1.70\u20135.20; p=0.00014). The\n                    <jats:italic>MUC5B<\/jats:italic>\n                    rs35705950 minor allele frequency (MAF) is greater for IPAF patients (23.2, 95% CI 18.8\u201328.2; p&lt;0.0001) than controls and is associated with worse transplant-free IPAF survival (hazard ratio 1.92, 95% CI 1.18\u20133.13; p=0.0091). Rheumatoid arthritis (RA)-associated ILD (RA-ILD) has a shorter LTL than non-RA CTD-ILD (\u22120.14\u00b10.27\n                    <jats:italic>versus<\/jats:italic>\n                    \u22120.01\u00b10.23; p=0.00055) and higher\n                    <jats:italic>MUC5B<\/jats:italic>\n                    MAF (34.6, 95% CI 24.4\u201346.3\n                    <jats:italic>versus<\/jats:italic>\n                    14.1, 95% CI 9.8\u201320.0; p=0.00025). Neither LTL nor\n                    <jats:italic>MUC5B<\/jats:italic>\n                    are associated with transplant-free CTD-ILD survival.\n                  <\/jats:p>\n                  <jats:p>\n                    LTL and\n                    <jats:italic>MUC5B<\/jats:italic>\n                    MAF have different associations with lung function progression and survival for IPAF and CTD-ILD.\n                  <\/jats:p>","DOI":"10.1183\/13993003.01641-2018","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T11:25:51Z","timestamp":1547205951000},"page":"1801641","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":176,"title":["Telomere length and genetic variant associations with interstitial lung disease progression and survival"],"prefix":"10.1183","volume":"53","author":[{"given":"Chad 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