{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:22:12Z","timestamp":1780633332936,"version":"3.54.1"},"reference-count":29,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,1,11]]},"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Lymphangioleiomyomatosis (LAM) is a cystic lung disease frequently associated with reduced exercise capacity. The aim of this study was to assess safety and efficacy of pulmonary rehabilitation in LAM.<\/jats:p>\n                  <jats:p>\n                    This controlled clinical trial included 40 patients with LAM and a low physical activity level. The pulmonary rehabilitation programme comprised 24 aerobic and muscle strength training sessions and education. The primary outcome was exercise capacity (endurance time during a constant work rate exercise test). Secondary outcomes included health-related quality of life (St George's Respiratory Questionnaire (SGRQ)), 6-min walking distance (6MWD), dyspnoea, peak oxygen consumption (\n                    <jats:italic>V<\/jats:italic>\n                    \u2032\n                    <jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    ), daily physical activity (pedometer), symptoms of anxiety and depression, lung function and peripheral muscle strength (one-repetition maximum).\n                  <\/jats:p>\n                  <jats:p>\n                    The baseline characteristics were well balanced between the groups. The pulmonary rehabilitation group exhibited improvements in the following outcomes\n                    <jats:italic>versus<\/jats:italic>\n                    controls: endurance time (median (interquartile range) 169 (2\u2013303)\u2005s\n                    <jats:italic>versus<\/jats:italic>\n                    \u221233 (\u2212129\u201339)\u2005s; p=0.001), SGRQ (median (interquartile range) \u22128 (\u221216\u20132)\n                    <jats:italic>versus<\/jats:italic>\n                    2 (\u22124\u20135); p=0.002) and 6MWD (median (interquartile range) 59 (13\u201381)\u2005m\n                    <jats:italic>versus<\/jats:italic>\n                    20 (\u221212\u201330) m; p=0.002). Dyspnoea, peak\n                    <jats:italic>V<\/jats:italic>\n                    \u2032\n                    <jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    , daily physical activity and muscle strength also improved significantly. No serious adverse events were observed.\n                  <\/jats:p>\n                  <jats:p>Pulmonary rehabilitation is a safe intervention and improves exercise capacity, dyspnoea, daily physical activity, quality of life and muscle strength in LAM.<\/jats:p>","DOI":"10.1183\/13993003.01683-2015","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:39:03Z","timestamp":1456439943000},"page":"1452-1460","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Pulmonary rehabilitation in lymphangioleiomyomatosis: a controlled clinical trial"],"prefix":"10.1183","volume":"47","author":[{"given":"Mariana S.","family":"Araujo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno G.","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina S.G.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 L.P.","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibele C.B.","family":"Marques da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo A.","family":"Kairalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso R.F.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos R.R.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"2024102023554589000_47.5.1452.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0848OE"},{"key":"2024102023554589000_47.5.1452.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100391"},{"key":"2024102023554589000_47.5.1452.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0372OC"},{"key":"2024102023554589000_47.5.1452.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1634ST"},{"key":"2024102023554589000_47.5.1452.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200508-1211ST"},{"key":"2024102023554589000_47.5.1452.6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00076209"},{"key":"2024102023554589000_47.5.1452.7","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180616b27"},{"key":"2024102023554589000_47.5.1452.8","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1249\/mss.0b013e3180d099ad","article-title":"Exercise training on disease control and quality of life in asthmatic children","volume":"39","author":"Fanelli","year":"2007","journal-title":"Med Sci Sports Exerc"},{"key":"2024102023554589000_47.5.1452.9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2418"},{"key":"2024102023554589000_47.5.1452.10","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200107001-00006"},{"key":"2024102023554589000_47.5.1452.11","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200202000-00027"},{"key":"2024102023554589000_47.5.1452.12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.6.751"},{"key":"2024102023554589000_47.5.1452.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(06)80166-6"},{"key":"2024102023554589000_47.5.1452.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"2024102023554589000_47.5.1452.15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.167.2.211"},{"key":"2024102023554589000_47.5.1452.16","doi-asserted-by":"publisher","DOI":"10.1080\/15412550903140873"},{"key":"2024102023554589000_47.5.1452.17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00116004"},{"key":"2024102023554589000_47.5.1452.18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1081\/COPD-200050576","article-title":"Factors determining constant work rate exercise tolerance in COPD and their role in dictating the minimal clinically important difference in response to interventions","volume":"2","author":"Casaburi","year":"2005","journal-title":"COPD"},{"key":"2024102023554589000_47.5.1452.19","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434010-00001"},{"key":"2024102023554589000_47.5.1452.20","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.076844"},{"key":"2024102023554589000_47.5.1452.21","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.9708010"},{"key":"2024102023554589000_47.5.1452.22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"key":"2024102023554589000_47.5.1452.23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150414"},{"key":"2024102023554589000_47.5.1452.24","first-page":"CD003793","article-title":"Pulmonary rehabilitation for chronic obstructive pulmonary disease","volume":"2","author":"McCarthy","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2024102023554589000_47.5.1452.25","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00068503a"},{"key":"2024102023554589000_47.5.1452.26","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0161"},{"key":"2024102023554589000_47.5.1452.27","first-page":"129","article-title":"Clinical course and characterisation of lymphangioleiomyomatosis in a Brazilian reference centre","volume":"31","author":"Baldi","year":"2014","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2024102023554589000_47.5.1452.28","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2025"},{"key":"2024102023554589000_47.5.1452.29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200302-162OC"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01683-2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:31:26Z","timestamp":1740360686000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01683-2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,4,30]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1183\/13993003.01683-2015"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01683-2015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726176062.793518323","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726176062.793546415","asserted-by":"object"}]},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,25]]}}}