{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:47:01Z","timestamp":1791179221108,"version":"4.1.0"},"reference-count":41,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2019,11,29]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Residual pulmonary impairment is common after treatment for tuberculosis (TB). Lung function data in patients with HIV-associated TB are scarce, especially in the context of paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) and prophylactic prednisone. We aimed to determine the prevalence of lung function abnormalities in patients with HIV-associated TB and CD4 counts \u2264100\u2005cells\u00b7\u03bcL<jats:sup>\u22121<\/jats:sup>and assess the effect of prophylactic prednisone and the development of paradoxical TB-IRIS on pulmonary impairment.<\/jats:p><jats:p>We performed spirometry, 6-min walk test (6MWT) and chest radiography at baseline (week 0) and at weeks 4, 12 and 28 in participants of the PredART trial, which evaluated a 28-day course of prednisone to prevent TB-IRIS in patients with HIV-associated TB commencing antiretroviral therapy.<\/jats:p><jats:p>153 participants underwent spirometry and\/or 6MWT at one or more time points. Abnormal spirometry measurements were present in 66% of participants at week 0 and 50% at week 28; low forced vital capacity was the commonest abnormality. Chest radiographs showed little or no abnormalities in the majority of participants. Prednisone use resulted in a 42\u2005m greater 6-min walk distance and a 4.9% higher percentage of predicted forced expiratory volume in 1\u2005s at week 4; these differences were no longer significantly different from week 12 onwards. TB-IRIS did not significantly impair lung function outcome.<\/jats:p><jats:p>Residual pulmonary impairment is common in HIV-associated TB. In patients with low CD4 counts, neither prophylactic prednisone as used in our study nor the development of TB-IRIS significantly affected week-28 pulmonary outcome.<\/jats:p>","DOI":"10.1183\/13993003.01692-2019","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T20:09:16Z","timestamp":1576872556000},"page":"1901692","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["The effect of HIV-associated tuberculosis, tuberculosis-IRIS and prednisone on lung function"],"prefix":"10.1183","volume":"55","author":[{"given":"Cari","family":"Stek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Allwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Du 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