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Multivariable linear regression models examined associations between SDB metrics and haemoglobin, glucose tolerance (haemoglobin A1c (HbA1c)), fasting glucose, homeostatic model-based assessments of insulin resistance and \u03b2-cell function (HOMA-IR and HOMA-\u03b2, respectively), blood pressure, and lipids, while adjusting for age, sex, body mass index (BMI) and wake oxygenation.<\/jats:p><jats:p>Participants (n=187; 91 men) were (median (interquartile range)) 52 (45\u201362) years old, and had a BMI of 27.0 (24.3\u201329.5) kg\u00b7m<jats:sup>\u22122<\/jats:sup>and 87% (85\u201388%) oxyhaemoglobin (arterial oxygen) saturation during wakefulness. In fully adjusted models, worsening nocturnal hypoxaemia was associated with haemoglobin elevations in men (p=0.03), independent of wake oxygenation and apnoea\u2013hypopnoea index (AHI), whereas worsening wake oxygenation was associated with haemoglobin elevations in older women (p=0.02). In contrast, AHI was independently associated with HbA1c elevations (p&lt;0.05). In single-variable models, nocturnal hypoxaemia was associated with higher HbA1c, HOMA-IR and HOMA-\u03b2 (p&lt;0.001, p=0.02 and p=0.04, respectively), whereas AHI was associated with HOMA-IR, systolic blood pressure and triglyceride elevations (p=0.02, p=0.01 and p&lt;0.01, respectively). These associations were not significant in fully adjusted models.<\/jats:p><jats:p>In highlanders, nocturnal hypoxaemia and sleep apnoea were associated with distinct cardiometabolic outcomes, conferring differential risk for excessive erythrocytosis and glucose intolerance, respectively.<\/jats:p>","DOI":"10.1183\/13993003.01705-2016","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T16:32:08Z","timestamp":1499358728000},"page":"1601705","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Cardiometabolic correlates of sleep disordered breathing in Andean highlanders"],"prefix":"10.1183","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-6315","authenticated-orcid":false,"given":"Luu V.","family":"Pham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine H.","family":"Miele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah G.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael S.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Rattner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Gilman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-5468","authenticated-orcid":false,"given":"J. 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