{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:52:19Z","timestamp":1761562339190,"version":"3.37.3"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"name":"A Yuhan research grant","award":["A faculty research grant in Yonsei University"],"award-info":[{"award-number":["A faculty research grant in Yonsei University"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,10,30]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Continuous positive airway pressure (CPAP) therapy may decrease left ventricular (LV) loads and improve myocardial oxygenation. In this study, we investigated the effect of CPAP on LV diastolic function compared with sham treatment in patients with severe obstructive sleep apnoea (OSA).<\/jats:p><jats:p>This 3-month prospective single-centre randomised sham-controlled trial analysed 52 patients with severe OSA. Patients were randomly assigned (1:1) to receive either CPAP or sham treatment for 3\u2005months. The main investigator and patients were masked to the trial randomisation. The primary end-point was change of early diastolic mitral annular (e\u2032) velocity over the 3-month period. Secondary end-points were pulse wave velocity (PWV), 24-h ambulatory blood pressure (BP) and variables of ventricular-vascular coupling at 3\u2005months.<\/jats:p><jats:p>After 3\u2005months of follow-up, CPAP treatment significantly increased the e\u2032 velocity, and was greater than the sham treatment (0.65\u00b11.70<jats:italic>versus<\/jats:italic>\u22120.61\u00b11.85\u2005cm\u00b7s<jats:sup>\u22121<\/jats:sup>, p=0.014). The PWV, 24-h mean diastolic BP, night-time diastolic BP, arterial elastance index and ventricular-vascular coupling index after 3\u2005months of follow-up decreased significantly in the CPAP group.<\/jats:p><jats:p>In patients with severe OSA, CPAP treatment for 3\u2005months improved LV diastolic function more than sham treatment, and was accompanied by improvements in arterial stiffness and ventricular-vascular coupling.<\/jats:p>","DOI":"10.1183\/13993003.01774-2017","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T01:50:22Z","timestamp":1517449822000},"page":"1701774","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of continuous positive airway pressure therapy on left ventricular diastolic function: a randomised, sham-controlled clinical trial"],"prefix":"10.1183","volume":"51","author":[{"given":"Chi 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