{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:04:27Z","timestamp":1776211467314,"version":"3.50.1"},"reference-count":42,"publisher":"European Respiratory Society (ERS)","issue":"4","funder":[{"DOI":"10.13039\/501100006549","name":"Bundesministerium f\u00fcr Umwelt, Naturschutz und Reaktorsicherheit","doi-asserted-by":"publisher","award":["FKZ 20462296"],"award-info":[{"award-number":["FKZ 20462296"]}],"id":[{"id":"10.13039\/501100006549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["MeDALL project"],"award-info":[{"award-number":["MeDALL project"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006628","name":"Mead Johnson Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001656","name":"Helmholtz-Gemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010886","name":"Nestl\u00e9 Health Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010886","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,1,11]]},"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Vitamin D plays a role in the development of the immune system and the lung, as well as in airway remodelling. Therefore, this study investigated the association between serum 25-hydroxyvitamin D (25(OH)D) concentrations and spirometric lung function parameters at age 15\u2005years.<\/jats:p><jats:p>In the German birth cohorts GINIplus and LISAplus, lung function testing by spirometry and 25(OH)D measurements were performed during the 15-year follow-up examinations. Valid lung function measurements pre- and\/or post-bronchodilation and serum 25(OH)D concentrations, which were adjusted for the date of blood sampling to account for seasonal variability, were available for 2607 adolescents. Associations between 25(OH)D concentrations and spirometric parameters were analysed using generalised additive models adjusted for confounding factors.<\/jats:p><jats:p>Serum 25(OH)D concentrations were significantly associated with forced vital capacity (FVC), forced expiratory volume in 1\u2005s (FEV<jats:sub>1<\/jats:sub>) and FEV<jats:sub>1<\/jats:sub>\/FVC measured before bronchodilation after adjustment for potential confounders: FEV<jats:sub>1<\/jats:sub>increased by 10\u2005mL (95% CI 2\u201317), FVC by 20\u2005mL (95% CI 12\u201328) and FEV<jats:sub>1<\/jats:sub>\/FVC decreased by 0.177% (95% CI \u22120.286 to \u22120.067) per 10\u2005nmol\u00b7L<jats:sup>\u22121<\/jats:sup>increase in 25(OH)D concentrations. Flow rates (forced expiratory flow rates at 25, 50 and 75% of exhaled FVC (FEF<jats:sub>25<\/jats:sub>, FEF<jats:sub>50<\/jats:sub>, FEF<jats:sub>75<\/jats:sub>) and mean flow rate between 25 and 75% of FVC (FEF<jats:sub>25\u201375<\/jats:sub>)) were not associated with vitamin D.\u00a0Similar associations were observed for lung function parameters measured after bronchodilation.<\/jats:p><jats:p>Vitamin D concentrations are positively associated with volume-related lung function parameters pre- and post-bronchodilation, suggesting structural changes in peripheral airways.<\/jats:p>","DOI":"10.1183\/13993003.01804-2016","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T20:20:56Z","timestamp":1494879656000},"page":"1601804","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Higher serum 25(OH)D concentrations are associated with improved FEV<sub>1<\/sub>and FVC in adolescence"],"prefix":"10.1183","volume":"49","author":[{"given":"Claudia","family":"Flexeder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Thiering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibylle","family":"Koletzko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"Berdel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"von Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl-Peter","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"2024101903481914000_49.4.1601804.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02711.x"},{"key":"2024101903481914000_49.4.1601804.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"2024101903481914000_49.4.1601804.3","doi-asserted-by":"crossref","first-page":"1087S","DOI":"10.1093\/ajcn\/87.4.1087S","article-title":"Blood biomarkers of vitamin D status","volume":"87","author":"Zerwekh","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"2024101903481914000_49.4.1601804.4","first-page":"27","article-title":"Vitamin D, allergies and asthma: focus on pediatric patients","volume":"7","author":"Della Giustina","year":"2014","journal-title":"World\u00a0Allergy Organ J"},{"key":"2024101903481914000_49.4.1601804.5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12887-014-0286-3","article-title":"Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies","volume":"14","author":"Wawro","year":"2014","journal-title":"BMC Pediatr"},{"key":"2024101903481914000_49.4.1601804.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00456.x"},{"key":"2024101903481914000_49.4.1601804.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00428.x"},{"key":"2024101903481914000_49.4.1601804.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.08.048"},{"key":"2024101903481914000_49.4.1601804.9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.151985"},{"key":"2024101903481914000_49.4.1601804.10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/ejcn.2011.6","article-title":"Serum 25-hydroxy-vitamin D and ionised calcium in relation to lung function and allergen skin tests","volume":"65","author":"Tolppanen","year":"2011","journal-title":"Eur J Clin Nutr"},{"key":"2024101903481914000_49.4.1601804.11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/EDE.obo13e318280dd5e","article-title":"Prospective association of 25-hydroxyvitamin D3 and D2 with childhood lung function, asthma, wheezing, and flexural dermatitis","volume":"24","author":"Tolppanen","year":"2013","journal-title":"Epidemiology"},{"key":"2024101903481914000_49.4.1601804.12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6.3792"},{"key":"2024101903481914000_49.4.1601804.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069714"},{"key":"2024101903481914000_49.4.1601804.14","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12299"},{"key":"2024101903481914000_49.4.1601804.15","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/all.12704","article-title":"No association between vitamin D and atopy, asthma, lung function or atopic dermatitis: a prospective study in adults","volume":"70","author":"Thuesen","year":"2015","journal-title":"Allergy"},{"key":"2024101903481914000_49.4.1601804.16","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv243"},{"key":"2024101903481914000_49.4.1601804.17","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.101"},{"key":"2024101903481914000_49.4.1601804.18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1365-2222.2009.03444.x","article-title":"Impact of early feeding on childhood eczema: development after nutritional intervention compared with the natural course \u2013 the GINIplus study up to the age of 6 years","volume":"40","author":"von Berg","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"2024101903481914000_49.4.1601804.19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.02322001"},{"key":"2024101903481914000_49.4.1601804.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00412.x"},{"key":"2024101903481914000_49.4.1601804.21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2024101903481914000_49.4.1601804.22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"2024101903481914000_49.4.1601804.23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"2024101903481914000_49.4.1601804.24","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. Vienna, The R Foundation, 2015. Available from: www.R-project.org"},{"key":"2024101903481914000_49.4.1601804.25","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177013604"},{"key":"2024101903481914000_49.4.1601804.26","doi-asserted-by":"publisher","DOI":"10.1038\/srep18138"},{"key":"2024101903481914000_49.4.1601804.27","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514561657"},{"key":"2024101903481914000_49.4.1601804.28","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/02770903.2015.1004339","article-title":"Association between vitamin D and respiratory outcomes in Canadian adolescents and adults","volume":"52","author":"Niruban","year":"2015","journal-title":"J Asthma"},{"key":"2024101903481914000_49.4.1601804.29","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.clinbiochem.2015.05.021","article-title":"Performance evaluation of four 25-hydroxyvitamin D assays to measure 25-hydroxyvitamin D2","volume":"48","author":"Freeman","year":"2015","journal-title":"Clin Biochem"},{"key":"2024101903481914000_49.4.1601804.30","first-page":"23","article-title":"Link between vitamin D and airway remodeling","volume":"7","author":"Berraies","year":"2014","journal-title":"J Asthma Allergy"},{"key":"2024101903481914000_49.4.1601804.31","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12410"},{"key":"2024101903481914000_49.4.1601804.32","doi-asserted-by":"publisher","DOI":"10.1586\/eci.09.53"},{"key":"2024101903481914000_49.4.1601804.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.1562"},{"key":"2024101903481914000_49.4.1601804.34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00096.x"},{"key":"2024101903481914000_49.4.1601804.35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/cea.12430","article-title":"Vitamin D and the development of allergic disease: how important is it?","volume":"45","author":"Mirzakhani","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"2024101903481914000_49.4.1601804.36","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1596OC"},{"key":"2024101903481914000_49.4.1601804.37","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00117.2014"},{"key":"2024101903481914000_49.4.1601804.38","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90539.2008"},{"key":"2024101903481914000_49.4.1601804.39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12931-016-0362-3","article-title":"Identification of vitamin D sensitive pathways during lung development","volume":"17","author":"Chen","year":"2016","journal-title":"Respir Res"},{"key":"2024101903481914000_49.4.1601804.40","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaci.2015.06.040","article-title":"Increased vitamin D levels at birth and in early infancy increase offspring allergy risk \u2013 evidence for involvement of epigenetic mechanisms","volume":"137","author":"Junge","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2024101903481914000_49.4.1601804.41","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0238-y"},{"key":"2024101903481914000_49.4.1601804.42","doi-asserted-by":"crossref","first-page":"e0159678","DOI":"10.1371\/journal.pone.0159678","article-title":"Age dependency of GLI reference values compared with paediatric lung function data in two German studies (GINIplus and LUNOKID","volume":"11","author":"H\u00fcls","year":"2016","journal-title":"PLoS One"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01804-2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:40:05Z","timestamp":1740379205000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01804-2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,26]]},"published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1183\/13993003.01804-2016"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01804-2016","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}